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, " Amber Boggs "

<rubyrue wrote:

>

> HI all, My husband has been having alot of pain in his rist from

Arthritis, one doctor told him he will need a thumb joint

replacement. We are just not willing to accept that fact. He also has

Arthritis in his feet knees etc. Besides glocosamean what can he do

to help this? Is there anything that can make the matter better? Or

is it just proventing it from gettign werse at this point?

> Any and al advice would be grate. Poor man can hardly hold our

baby.

> mber

>

 

 

Mangostin Inhibits Inhibitor-B Kinase Activity and

 

Decreases Lipopolysaccharide-Induced Cyclooxygenase-2

 

Gene Expression in C6 Rat Glioma Cells

 

Charles Heydon

www.SoCalJuiceBiz.com

661-305-2737

1cor.10:31

 

Keigo Nakatani,1 Tohru Yamakuni, Nobuhiko Kondo, Tsutomu Arakawa,

Kenji Oosawa,

 

Susumu Shimura, Hiroyasu Inoue, and Yasushi Ohizumi

 

Department of Pharmaceutical Molecular Biology, Graduate School of

Pharmaceutical Sciences, Tohoku University, Sendai,

 

Japan (K.N., T.Y., N.K., Y.O.); Central Laboratory, Lotte Co., Ltd.,

Saitama, Japan (T.A., K.O., S.S.); and Department of

 

Pharmacology, National Cardiovascular Center Research Institute,

Osaka, Japan (H.I.)

 

Received May 11, 2004; accepted June 18, 2004

 

ABSTRACT

 

We investigated the effect of -mangostin purified from the fruit

 

hull of the medicinal plant Garcinia mangostana on spontaneous

 

prostaglandin E2 (PGE2) release and inducible cyclooxygenase

 

2 (COX-2) gene expression in C6 rat glioma cells. An

 

18-h treatment with -mangostin potently inhibited spontaneous

 

PGE2 release in a concentration-dependent manner with

 

the IC50 value of approximately 2 M, without affecting the cell

 

viability even at 30 M. By immunoblotting and reverse-transcription

 

polymerase chain reaction, we showed that -mangostin

 

concentration-dependently inhibited lipopolysaccharide

 

(LPS)-induced expression of COX-2 protein and its mRNA, but

 

not those of constitutive COX-1 cyclooxygenase. Because LPS

 

is known to stimulate inhibitor B (IB) kinase (IKK)-mediated

 

phosphorylation of IB followed by its degradation, which in

 

turn induces nuclear factor (NF)-B nuclear translocation leading

 

to transcriptional activation of COX-2 gene, the effect of

 

-mangostin on the IKK/IB cascade controlling the NF-B

 

activation was examined. An in vitro IKK assay using IKK protein

 

immunoprecipitated from C6 cell extract showed that this

 

compound inhibited IKK activity in a concentration-dependent

 

manner, with the IC50 value of approximately 10 M. Consistently

 

-mangostin was also observed to decrease the LPSinduced

 

IB degradation and phosphorylation in a concentration-

 

dependent manner, as assayed by immunoblotting.

 

Furthermore, luciferase reporter assays showed that -mangostin

 

reduced the LPS-inducible activation of NF-B–and human

 

COX-2 gene promoter region-dependent transcription.

 

-Mangostin also inhibited rat carrageenan-induced paw

 

edema. These results suggest that -mangostin directly inhibits

 

IKK activity and thereby prevents COX-2 gene transcription, an

 

NF-B target gene, probably to decrease the inflammatory

 

agent-stimulated PGE2 production in vivo, and is a new useful

 

lead compound for anti-inflammatory drug development.

 

Prostaglandins (PGs), arachidonic acid (AA) metabolites of

 

the cyclooxygenase (COX) pathway, are major mediators in

 

the regulation of inflammation and immune function (Smith

 

et al., 2000). In the brain, the prostaglandin E2 (PGE2) is the

 

most abundant PG. PGE2 levels are very low or undetectable

 

in normal conditions but can rise in response to inflammatory

 

processes, multiple sclerosis, and AIDS-associated dementia

 

(Fretland, 1992; Griffin et al., 1994). High levels of

 

PGE2 can modulate the activities of multiple cell types,

 

including neurons, glial, and endothelial cells, as well as

 

microglia/macrophage and lymphocyte functions during inflammatory

 

and immune processes (Weissmann, 1993). Astrocytes

 

are a known important source of PGE2 in the CNS

 

(Katsuura et al., 1989). Their ability to produce PGE2 upon

 

stimulation with interleukin (IL)-1, tumor necrosis factor-

 

(TNF-), or bacterial wall protein lipopolysaccharide (LPS) has

 

been extensively documented (Fontana et al., 1982; Mollace et

 

al., 1998; Molina-Holgado et al., 2000).

 

Cyclooxygenase (COX) is well known to be responsible for

 

PG production and the rate-limiting enzymes. This enzyme

 

This work was partly supported by a Grant-in-Aid for Scientific

Research

 

from the Ministry of Education, Science, Sport and Culture of Japan.

 

1 Current address: Pfizer Global Research and Development, Nagoya

Laboratories,

 

Aichi, Japan.

 

Article, publication date, and citation information can be found at

 

http://molpharm.aspetjournals.org.

 

doi:10.1124/mol.104.002626.

 

ABBREVIATIONS: PG, prostaglandin; AA, arachidonic acid; COX,

cyclooxygenase; COX-1, constitutive cyclooxygenase; COX-2, inducible

 

cyclooxygenase; PGE2, prostaglandin E2; LPS, lipopolysaccharide; IB,

inhibitor B; IKK, inhibitor B kinase; CNS, central nervous system;

IL,

 

interleukin; TNF-, tumor necrosis factor-; NF-B, nuclear factor-B;

MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; RT,

reverse

 

transcription; PCR, polymerase chain reaction; PAGE, polyacrylamide

gel electrophoresis; ODS, octadecylsilyl; HPLC, high-performance

liquid

 

chromatography; DMSO, dimethyl sulfoxide; NS398, N-[2-

(cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide.

 

Charles Heydon

www.SoCalJuiceBiz.com

661-305-2737

1cor.10:31

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What's his diet like? Have him eliminate all forms of sugar

(including artificial sugar), meat, junk food, dairy. All that is

very acid forming. Most diseases cannot manifest in an alkaline body.

Do a google search for alkaline foods.

 

Carol

 

, " Amber Boggs " <rubyrue

wrote:

>

> HI all, My husband has been having alot of pain in his rist from

Arthritis, one doctor told him he will need a thumb joint replacement.

We are just not willing to accept that fact. He also has Arthritis in

his feet knees etc. Besides glocosamean what can he do to help this?

Is there anything that can make the matter better? Or is it just

proventing it from gettign werse at this point?

> Any and al advice would be grate. Poor man can hardly hold our baby.

> mber

>

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Amber

have you got any magnesium oil?

It gives me great relief when I have hand/write/ankle pain I make it myself, and keep it in a spray bottle for application when needed

Do you know how to make your own?

 

 

The word OIL is a tad misleading, however it does describe the feeling the liquid has when applied initially to your skin.

 

At the Co-cure site it says:

you can make your own magnesium oil for way cheaper.you need nigari(Magnesium chloride) its used to make tofu, all magnesium oil is is nigari mixed with water, ive been making it for a few months now and my muscle cramps and muscle twitches are completly gone

 

The secret (also a misnomer - coz its no secret) is to start by mixing a cupful of Mg Chloride with water until it is dissolved..... then add more and dissolve it ad infinitum until the liquid will take no more dried Magnesium flakes...... it has reached I think tiz called 'saturation point'...... put it into a spray bottle and BINGO.... you have the same stuff at much less cost.

 

We bought a 25Kg (50lbs there abouts) sack of the stuff at a farm supplies shop (it is used on the land too) and have it on hand. It gets dumped by the jug full into the bath water for soaking in.... great in foot baths too.

 

If you want the purer form, then get the NIGARI as mentioned above and do the same thing ... to saturation point then you have your own Mg Oil.

 

Cheer's from Clare in Tassie

 

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Consider doing some research on vitamin B6/P5P.It has worked miracles for us.All the best,YannicOn Thu, Jan 29, 2009 at 11:41 PM, Amber Boggs <rubyrue wrote:

 

 

 

 

 

 

HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point?

Any and al advice would be grate. Poor man can hardly hold our baby.

mber

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Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low

sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck.

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That is not true - I'm living proof. That's something a mainstream

doctor will tell you, that there is no cure. Most degenerative

conditions are reversible - it just takes work, which most people are

not willing to do - they want a quick fix with medication to make them

feel better, but that does nothing to address the underlying cause,

which is an over acidic body and not enough of the proper foods.

 

Carol

 

, Lanosrep Noitamrofni

<lanosrep.noitamrofni wrote:

>

> Unfortunately once somebody has arthritis, they have it for good. 

There is no cure. 

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Not sure where you base that statement on... that people once they have

it, have it for good.

I had it, in the early nineties... and I do not have it anymore!

 

 

At 12:59 AM 31/01/2009, you wrote:

Unfortunately once somebody has

arthritis, they have it for good. There is no cure.

Fortunately there are treatments which can help minimize the pain of

inflammation and damage associated with arthritis. A good diet will

help. Especially if he has a form of reactive arthritis that can be

worsened by an offending substance that triggers the immune system to

react with inflammation.

The first step in knowing how to deal with arthritis is having it

properly diagnosed, as there are many many forms. A Rheumatologist

can help with diagnosing which kind of arthritis he has, and can offer

treatment options; however, it is unlikely that the doctor will mention

diet changes. So that is something your husband will have to

endevour to find out about on his own or with a dietician or

nutritionist.

Low starch, low sugar, high protein, and vitamins from fresh fruits and

veggies are pretty much good diet changes for many ailments.

Good luck.

 

 

 

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I beg to differ on this opinion of arthritis. If it is caused by a pathogen, lets say...lyme disease, it is indeed curable! I have going through this with my family for years. My joint pain is now gone for the most part as well as my kids knee pain to the point of not walking at some points. My homeopathist's son had lyme disease and they (doctors) told her he would never be able to do sports again because of the damage to his knees. Using only homeopathy, she cured him of lyme and he can now do all the normal sports his peers can.I believe that most anything can be cured and/or reversed if you can find out what is causing the damage. I read a book entiltled "Eric is Winning." This is a man who was almost all the way wheelchair bound by ALS. Simply trough extensive detoxification methods, he was able to reverse much of the damage done and was still doing well 10 years later. In retrospect, he probably had lyme disease and didn't know it as much of the damage from lyme is done by toxic build up. They are finding that most neurological diseases may be due to lyme and its co-infections (this list included ALS, parkinsons, MS, etc). Susan Siegel On Jan 30, 2009, at 9:29 AM, Lanosrep Noitamrofni wrote:Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck.

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Excellent points. RHEUMATOID ARTHRITS especially is a systemic infection that may be causes by bacterial and/or viral infections and/or food sensitivities and/or poisoning by heavy metals or chemicals. It is far too complicated for the medical establishment to affect a cure when they can use prednisone, methotrexate, Remicade, etc to keep you their prisoner for life.

 

Homeopathic and naturopathic physicians are necessary stops on your route to a cure. Drugs may be necessary to temporarily mask the pain but all the drugs in use must be stopped at some time before they become a "syndrome" unto themselves.--- On Sat, 1/31/09, Susan Siegel <ssiegel5 wrote:

Susan Siegel <ssiegel5Re: Re:Arthritis Date: Saturday, January 31, 2009, 10:45 AM

I beg to differ on this opinion of arthritis. If it is caused by a pathogen, lets say...lyme disease, it is indeed curable! I have going through this with my family for years. My joint pain is now gone for the most part as well as my kids knee pain to the point of not walking at some points. My homeopathist's son had lyme disease and they (doctors) told her he would never be able to do sports again because of the damage to his knees. Using only homeopathy, she cured him of lyme and he can now do all the normal sports his peers can.

 

I believe that most anything can be cured and/or reversed if you can find out what is causing the damage. I read a book entiltled "Eric is Winning." This is a man who was almost all the way wheelchair bound by ALS. Simply trough extensive detoxification methods, he was able to reverse much of the damage done and was still doing well 10 years later. In retrospect, he probably had lyme disease and didn't know it as much of the damage from lyme is done by toxic build up. They are finding that most neurological diseases may be due to lyme and its co-infections (this list included ALS, parkinsons, MS, etc).

 

 

Susan Siegel

 

On Jan 30, 2009, at 9:29 AM, Lanosrep Noitamrofni wrote:

 

 

 

 

 

Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low

starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck.

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Google to the rescue...

At 11:34 AM 8/02/2009, you wrote:

What is DMSO please?

 

Terri

 

 

 

 

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Hi Amber,

 

I very rarely go onto my email or read all the posts from the health and healing group. But just did, and saw your posts and others replies.. So thought I would send you a note to add to your pile of info to sift through!

 

W/ arthritis, one of the keys is to get to the root cause. Everything else is just a bandaid, and usually those are short lived. You say he was tested for Lyme, but please know, most of those tests are not accurate enough, but one is, and if your interested let me know and I will get you the info on the one that is proven to find the truth there.

 

Also, w/ arthritis, the glucosamines, chondroitan sulfates, etc, etc.... all of these, including NSAID's, (like motrin/advil, etc.) these inhibit nitric oxide, a molecule in the blood that is responsible for not only increasing circulation, but in large enough amounts can completely erradicate harmful inflammation, because it targets a protein in the blood that creates inflammation, so stops it in its; tracks. The other anti inflamm substances, like the NSAID's, and glucosamines, etc.. those decrease circulation since they block or inhibit that nitric oxide molecule.

 

So, that said, if you eliminate all nitric oxide inhibiting substances/drugs, and this includes topicals like DMSO, then instead increase nitric oxide in a healthy way, you can really make a huge dent in the inflammation, while flushing out the nasties in the system that are causing more pain/problems. I know several formulas that work, and work very well. And one has even been used very successfully for those who do have Lyme, and it works. Another issue to address w/ arthritis is toxicty in the system, this causes and or contributes more than most of us know. So a good safe detox that works at the cellular level is another very helpful benefit. Also, none of this is expensive and all of it is good for your health and well being.

 

Last, and this part can be pricey, but use of a low level laser can be another exceptional benefit. These lasers stimulate and excite the cells to work much faster. And with injuries, toxins in the system, inflammation built up, delayed healing abilities, etc. these cells become stagnant and need to be ramped up and forced to work efficiently again. Lasers do this, and they utilize the nitric oxide in the blood to do even more.

 

So, if you gently detox the system, delete any nitric oxide inhibiting substances, instead, increase nitric oxide in the system, and while it is peaking in the system (different time frames for different products/etc,,.) but while the NO is peeking in the system, if you can follow w/ low level laser therapy to optimize the flushing of the system, circulation, targeting the inflammation in it;s tracks, etc etc... the results can be phemonenal, and these are not bandaids, but are literally eliminating the "cause".

 

Best wishes, and if I can pass on any other info, please don't hesitate to email me.

 

Dana--- On Thu, 1/29/09, Amber Boggs <rubyrue wrote:

Amber Boggs <rubyrue Arthritis Date: Thursday, January 29, 2009, 2:41 PM

 

 

 

HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point?

Any and al advice would be grate. Poor man can hardly hold our baby.

mber

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DiMethylSulfOxide

 

 

 

T M <gettinghealthier Sent: Saturday, February 7, 2009 5:04:21 PMRe: Arthritis

 

 

What is DMSO please?

 

Terri

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Thanks.

On Sat, Feb 7, 2009 at 7:54 PM, Hugh Ramsdell <hughman73 wrote:

 

 

 

 

 

 

 

DiMethylSulfOxide

 

 

 

T M <gettinghealthier Sent: Saturday, February 7, 2009 5:04:21 PM

Re: Arthritis

 

 

What is DMSO please?

 

Terri

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I tried CMO on my dog for quite awhile at one point for arthritis and didn't help at all, the only thing that has helped him was MSM & CS.

 

Tammatha

 

-

Michael Goebel

Butch Owen ; Oleander Soup

Monday, April 20, 2009 8:24 AM

Arthritis

 

 

 

 

 

 

Hi, Butch and Group,I have arthritis throughout my entire spine. -- Too many motorcycle accidents!--I have used just about everything. One product stands out as clearly superior. It cannot be patented because it is natural. The product is called CMO, trans-ceramyl-9-cetyl myristoleate.CMO was discovered by Harry W. Diehl shortly before he retired from the National Institutes of Health. He could not produce arthritis in mice. This led to an extensive investigation of mice. He retired as he was doing this research. He continued in his home laboratory until he had extracted several fatty acids which mice genetically code and produce. Chief among these was CMO.He tried the extract on Rats, cats, dogs, monkeys, etc. Eventually his arthritic neighbors coerced him to let them try it. Each species had phenomenal success in response to CMO. The last reported data I have read said the of the folks who have taken CMO, 87% report complete, lasting relief, and the remaining 13% report very significant relief. (Compare that to a drug study!) The original protocol was to take one 500 mg capsule of CMO per day for 40 straight days. (I began to get relief from the 17th day forward.) I have not seen it fail to give total or near complete relief on any friend or patient who had tried it.One transmission mechanic with ankylosing spodylitis reported it had been the only things that had given him any relief in over 5 years.CMO is available from a number of distributors. My personal supply I use and resell comes from richdistributing.comI hope this post helps a lot of folks in the group.Michael L Goebel, DC, ACN

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Smart boy keep your intestines clean, take a mild purgative once a week and fast

once a week. not the kind of fast Indian women keep where they are off grains

but eat the heaviest of food. Just be on juices. and the next day after the fast

also go light on food. This is a vata dosh so see that vata is tackled. You may

have two pods of raw garlic in the morning, you may also have quarter spoon of

cinnamon powder awith a tea spoon of honey. Taking triphala benefits every one.

Flaxseeds also help in arthritis and so does the water kept in a coppper

container help if we drink that water. 

I am not a doctor but this is my practical experience through which I am

writing this.

 

 

 

 

________________________________

 

any ayurvedic cure for arthritis ??

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Ayurveda offers the best of the management of Arthritis among the contemporary

medical sciences. Kindly revert with the variety of  Arthritis, one is

suffering. 

 

Thanks & Regards,

Dr.Deshpande

www.phytoinc.com

+91 96865 54464

+91 94480 09151

________________

 

any ayurvedic cure for arthritis ??

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Malhotraji,

Hari Om !

 

Respected Mridulaji Sharma & Dr. Sudheendraji Deshpande have

suggested in right direction.

 

There are over 100 different forms of arthritis.

Irrespective of the type of arthritis, the common symptoms for all arthritis

disorders include pain and a constant ache around the

joint(s).

 

The pain from arthritis occurs due to inflammation that occurs

around the joint, damage to the joint from disease, daily wear and tear of

joint, muscles strains caused by forceful movements against stiff, painful

joints and fatigue.

 

There is some evidence that consuming the commonly-eaten Nightshade plants

(tomatoes, potatoes, eggplant, bell pepper family, and tobacco) is the causing

factor in arthritis.

 

In arthritis the joints become stiff and the range of movements is limited.

Physical therapy can teach you how to relax the stiff joint and not damage the

joint. Moreover, physical therapy can provide splints or braces for your joints.

There are also assist devices available that can help you drive, getting a bath,

dressing and also in housekeeping labors.

 

Occupation therapy can teach you how to reduce stress on your

joint from daily living activities. Occupation therapy can also teach

you how to modify your home and work environment so that you do reduce

movements that may worsen your arthritis.

 

Studies have shown that physical exercise of the affected joint can have

noticeable improvement in terms of long-term pain relief.

 

Furthermore, exercise of the arthritic joint is encouraged to maintain the

health of the particular joint and the overall body of the person.

 

A few Asanas & Pranayams, if done regularly, are really helpful. There are many

herbs which control arthritis disorders include pain and a constant ache

around the joint(s) but it is difficult for a common man to prepare a mix of

these herbs.

 

So, take RUMALAYA tablets, product of The Himalaya Drug Company Limited,

regularly for a few months alongwith a few Asanas & exercises suggested by Rev.

Swami Ramdevji.

 

Best wishes,

Swami Brahmavidyananda Saraswati

___________

> any ayurvedic cure for arthritis ??

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