Guest guest Report post Posted January 30, 2009 , " Amber Boggs " <rubyrue wrote: > > HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point? > Any and al advice would be grate. Poor man can hardly hold our baby. > mber > Mangostin Inhibits Inhibitor-B Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells Charles Heydon www.SoCalJuiceBiz.com 661-305-2737 1cor.10:31 Keigo Nakatani,1 Tohru Yamakuni, Nobuhiko Kondo, Tsutomu Arakawa, Kenji Oosawa, Susumu Shimura, Hiroyasu Inoue, and Yasushi Ohizumi Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (K.N., T.Y., N.K., Y.O.); Central Laboratory, Lotte Co., Ltd., Saitama, Japan (T.A., K.O., S.S.); and Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan (H.I.) Received May 11, 2004; accepted June 18, 2004 ABSTRACT We investigated the effect of -mangostin purified from the fruit hull of the medicinal plant Garcinia mangostana on spontaneous prostaglandin E2 (PGE2) release and inducible cyclooxygenase 2 (COX-2) gene expression in C6 rat glioma cells. An 18-h treatment with -mangostin potently inhibited spontaneous PGE2 release in a concentration-dependent manner with the IC50 value of approximately 2 M, without affecting the cell viability even at 30 M. By immunoblotting and reverse-transcription polymerase chain reaction, we showed that -mangostin concentration-dependently inhibited lipopolysaccharide (LPS)-induced expression of COX-2 protein and its mRNA, but not those of constitutive COX-1 cyclooxygenase. Because LPS is known to stimulate inhibitor B (IB) kinase (IKK)-mediated phosphorylation of IB followed by its degradation, which in turn induces nuclear factor (NF)-B nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of -mangostin on the IKK/IB cascade controlling the NF-B activation was examined. An in vitro IKK assay using IKK protein immunoprecipitated from C6 cell extract showed that this compound inhibited IKK activity in a concentration-dependent manner, with the IC50 value of approximately 10 M. Consistently -mangostin was also observed to decrease the LPSinduced IB degradation and phosphorylation in a concentration- dependent manner, as assayed by immunoblotting. Furthermore, luciferase reporter assays showed that -mangostin reduced the LPS-inducible activation of NF-B–and human COX-2 gene promoter region-dependent transcription. -Mangostin also inhibited rat carrageenan-induced paw edema. These results suggest that -mangostin directly inhibits IKK activity and thereby prevents COX-2 gene transcription, an NF-B target gene, probably to decrease the inflammatory agent-stimulated PGE2 production in vivo, and is a new useful lead compound for anti-inflammatory drug development. Prostaglandins (PGs), arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, are major mediators in the regulation of inflammation and immune function (Smith et al., 2000). In the brain, the prostaglandin E2 (PGE2) is the most abundant PG. PGE2 levels are very low or undetectable in normal conditions but can rise in response to inflammatory processes, multiple sclerosis, and AIDS-associated dementia (Fretland, 1992; Griffin et al., 1994). High levels of PGE2 can modulate the activities of multiple cell types, including neurons, glial, and endothelial cells, as well as microglia/macrophage and lymphocyte functions during inflammatory and immune processes (Weissmann, 1993). Astrocytes are a known important source of PGE2 in the CNS (Katsuura et al., 1989). Their ability to produce PGE2 upon stimulation with interleukin (IL)-1, tumor necrosis factor- (TNF-), or bacterial wall protein lipopolysaccharide (LPS) has been extensively documented (Fontana et al., 1982; Mollace et al., 1998; Molina-Holgado et al., 2000). Cyclooxygenase (COX) is well known to be responsible for PG production and the rate-limiting enzymes. This enzyme This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sport and Culture of Japan. 1 Current address: Pfizer Global Research and Development, Nagoya Laboratories, Aichi, Japan. Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org. doi:10.1124/mol.104.002626. ABBREVIATIONS: PG, prostaglandin; AA, arachidonic acid; COX, cyclooxygenase; COX-1, constitutive cyclooxygenase; COX-2, inducible cyclooxygenase; PGE2, prostaglandin E2; LPS, lipopolysaccharide; IB, inhibitor B; IKK, inhibitor B kinase; CNS, central nervous system; IL, interleukin; TNF-, tumor necrosis factor-; NF-B, nuclear factor-B; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; RT, reverse transcription; PCR, polymerase chain reaction; PAGE, polyacrylamide gel electrophoresis; ODS, octadecylsilyl; HPLC, high-performance liquid chromatography; DMSO, dimethyl sulfoxide; NS398, N-[2- (cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide. Charles Heydon www.SoCalJuiceBiz.com 661-305-2737 1cor.10:31 Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 30, 2009 What's his diet like? Have him eliminate all forms of sugar (including artificial sugar), meat, junk food, dairy. All that is very acid forming. Most diseases cannot manifest in an alkaline body. Do a google search for alkaline foods. Carol , " Amber Boggs " <rubyrue wrote: > > HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point? > Any and al advice would be grate. Poor man can hardly hold our baby. > mber > Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 30, 2009 Amber have you got any magnesium oil? It gives me great relief when I have hand/write/ankle pain I make it myself, and keep it in a spray bottle for application when needed Do you know how to make your own? The word OIL is a tad misleading, however it does describe the feeling the liquid has when applied initially to your skin. At the Co-cure site it says: you can make your own magnesium oil for way cheaper.you need nigari(Magnesium chloride) its used to make tofu, all magnesium oil is is nigari mixed with water, ive been making it for a few months now and my muscle cramps and muscle twitches are completly gone The secret (also a misnomer - coz its no secret) is to start by mixing a cupful of Mg Chloride with water until it is dissolved..... then add more and dissolve it ad infinitum until the liquid will take no more dried Magnesium flakes...... it has reached I think tiz called 'saturation point'...... put it into a spray bottle and BINGO.... you have the same stuff at much less cost. We bought a 25Kg (50lbs there abouts) sack of the stuff at a farm supplies shop (it is used on the land too) and have it on hand. It gets dumped by the jug full into the bath water for soaking in.... great in foot baths too. If you want the purer form, then get the NIGARI as mentioned above and do the same thing ... to saturation point then you have your own Mg Oil. Cheer's from Clare in Tassie Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 30, 2009 Consider doing some research on vitamin B6/P5P.It has worked miracles for us.All the best,YannicOn Thu, Jan 29, 2009 at 11:41 PM, Amber Boggs <rubyrue wrote: HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point? Any and al advice would be grate. Poor man can hardly hold our baby. mber Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 30, 2009 Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 31, 2009 That is not true - I'm living proof. That's something a mainstream doctor will tell you, that there is no cure. Most degenerative conditions are reversible - it just takes work, which most people are not willing to do - they want a quick fix with medication to make them feel better, but that does nothing to address the underlying cause, which is an over acidic body and not enough of the proper foods. Carol , Lanosrep Noitamrofni <lanosrep.noitamrofni wrote: > > Unfortunately once somebody has arthritis, they have it for good. There is no cure. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 31, 2009 Not sure where you base that statement on... that people once they have it, have it for good. I had it, in the early nineties... and I do not have it anymore! At 12:59 AM 31/01/2009, you wrote: Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation. The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments. Good luck. avast! Antivirus: Inbound message clean. Virus Database (VPS): 090130-0, 30/01/2009 Tested on: 31/01/2009 6:12:26 PM avast! - copyright © 1988-2009 ALWIL Software. avast! Antivirus: Outbound message clean. Virus Database (VPS): 090130-0, 30/01/2009Tested on: 1/02/2009 1:16:17 AMavast! - copyright © 1988-2009 ALWIL Software. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted January 31, 2009 I beg to differ on this opinion of arthritis. If it is caused by a pathogen, lets say...lyme disease, it is indeed curable! I have going through this with my family for years. My joint pain is now gone for the most part as well as my kids knee pain to the point of not walking at some points. My homeopathist's son had lyme disease and they (doctors) told her he would never be able to do sports again because of the damage to his knees. Using only homeopathy, she cured him of lyme and he can now do all the normal sports his peers can.I believe that most anything can be cured and/or reversed if you can find out what is causing the damage. I read a book entiltled "Eric is Winning." This is a man who was almost all the way wheelchair bound by ALS. Simply trough extensive detoxification methods, he was able to reverse much of the damage done and was still doing well 10 years later. In retrospect, he probably had lyme disease and didn't know it as much of the damage from lyme is done by toxic build up. They are finding that most neurological diseases may be due to lyme and its co-infections (this list included ALS, parkinsons, MS, etc). Susan Siegel On Jan 30, 2009, at 9:29 AM, Lanosrep Noitamrofni wrote:Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 2, 2009 Excellent points. RHEUMATOID ARTHRITS especially is a systemic infection that may be causes by bacterial and/or viral infections and/or food sensitivities and/or poisoning by heavy metals or chemicals. It is far too complicated for the medical establishment to affect a cure when they can use prednisone, methotrexate, Remicade, etc to keep you their prisoner for life. Homeopathic and naturopathic physicians are necessary stops on your route to a cure. Drugs may be necessary to temporarily mask the pain but all the drugs in use must be stopped at some time before they become a "syndrome" unto themselves.--- On Sat, 1/31/09, Susan Siegel <ssiegel5 wrote: Susan Siegel <ssiegel5Re: Re:Arthritis Date: Saturday, January 31, 2009, 10:45 AM I beg to differ on this opinion of arthritis. If it is caused by a pathogen, lets say...lyme disease, it is indeed curable! I have going through this with my family for years. My joint pain is now gone for the most part as well as my kids knee pain to the point of not walking at some points. My homeopathist's son had lyme disease and they (doctors) told her he would never be able to do sports again because of the damage to his knees. Using only homeopathy, she cured him of lyme and he can now do all the normal sports his peers can. I believe that most anything can be cured and/or reversed if you can find out what is causing the damage. I read a book entiltled "Eric is Winning." This is a man who was almost all the way wheelchair bound by ALS. Simply trough extensive detoxification methods, he was able to reverse much of the damage done and was still doing well 10 years later. In retrospect, he probably had lyme disease and didn't know it as much of the damage from lyme is done by toxic build up. They are finding that most neurological diseases may be due to lyme and its co-infections (this list included ALS, parkinsons, MS, etc). Susan Siegel On Jan 30, 2009, at 9:29 AM, Lanosrep Noitamrofni wrote: Unfortunately once somebody has arthritis, they have it for good. There is no cure. Fortunately there are treatments which can help minimize the pain of inflammation and damage associated with arthritis. A good diet will help. Especially if he has a form of reactive arthritis that can be worsened by an offending substance that triggers the immune system to react with inflammation.The first step in knowing how to deal with arthritis is having it properly diagnosed, as there are many many forms. A Rheumatologist can help with diagnosing which kind of arthritis he has, and can offer treatment options; however, it is unlikely that the doctor will mention diet changes. So that is something your husband will have to endevour to find out about on his own or with a dietician or nutritionist. Low starch, low sugar, high protein, and vitamins from fresh fruits and veggies are pretty much good diet changes for many ailments.Good luck. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 7, 2009 Google to the rescue... At 11:34 AM 8/02/2009, you wrote: What is DMSO please? Terri avast! Antivirus: Inbound message clean. Virus Database (VPS): 090207-0, 07/02/2009 Tested on: 7/02/2009 12:16:05 PM avast! - copyright © 1988-2009 ALWIL Software. avast! Antivirus: Outbound message clean. Virus Database (VPS): 090207-0, 07/02/2009Tested on: 7/02/2009 12:30:09 PMavast! - copyright © 1988-2009 ALWIL Software. Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 7, 2009 Hi Amber, I very rarely go onto my email or read all the posts from the health and healing group. But just did, and saw your posts and others replies.. So thought I would send you a note to add to your pile of info to sift through! W/ arthritis, one of the keys is to get to the root cause. Everything else is just a bandaid, and usually those are short lived. You say he was tested for Lyme, but please know, most of those tests are not accurate enough, but one is, and if your interested let me know and I will get you the info on the one that is proven to find the truth there. Also, w/ arthritis, the glucosamines, chondroitan sulfates, etc, etc.... all of these, including NSAID's, (like motrin/advil, etc.) these inhibit nitric oxide, a molecule in the blood that is responsible for not only increasing circulation, but in large enough amounts can completely erradicate harmful inflammation, because it targets a protein in the blood that creates inflammation, so stops it in its; tracks. The other anti inflamm substances, like the NSAID's, and glucosamines, etc.. those decrease circulation since they block or inhibit that nitric oxide molecule. So, that said, if you eliminate all nitric oxide inhibiting substances/drugs, and this includes topicals like DMSO, then instead increase nitric oxide in a healthy way, you can really make a huge dent in the inflammation, while flushing out the nasties in the system that are causing more pain/problems. I know several formulas that work, and work very well. And one has even been used very successfully for those who do have Lyme, and it works. Another issue to address w/ arthritis is toxicty in the system, this causes and or contributes more than most of us know. So a good safe detox that works at the cellular level is another very helpful benefit. Also, none of this is expensive and all of it is good for your health and well being. Last, and this part can be pricey, but use of a low level laser can be another exceptional benefit. These lasers stimulate and excite the cells to work much faster. And with injuries, toxins in the system, inflammation built up, delayed healing abilities, etc. these cells become stagnant and need to be ramped up and forced to work efficiently again. Lasers do this, and they utilize the nitric oxide in the blood to do even more. So, if you gently detox the system, delete any nitric oxide inhibiting substances, instead, increase nitric oxide in the system, and while it is peaking in the system (different time frames for different products/etc,,.) but while the NO is peeking in the system, if you can follow w/ low level laser therapy to optimize the flushing of the system, circulation, targeting the inflammation in it;s tracks, etc etc... the results can be phemonenal, and these are not bandaids, but are literally eliminating the "cause". Best wishes, and if I can pass on any other info, please don't hesitate to email me. Dana--- On Thu, 1/29/09, Amber Boggs <rubyrue wrote: Amber Boggs <rubyrue Arthritis Date: Thursday, January 29, 2009, 2:41 PM HI all, My husband has been having alot of pain in his rist from Arthritis, one doctor told him he will need a thumb joint replacement. We are just not willing to accept that fact. He also has Arthritis in his feet knees etc. Besides glocosamean what can he do to help this? Is there anything that can make the matter better? Or is it just proventing it from gettign werse at this point? Any and al advice would be grate. Poor man can hardly hold our baby. mber Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 8, 2009 What is DMSO please? Terri Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 8, 2009 DiMethylSulfOxide T M <gettinghealthier Sent: Saturday, February 7, 2009 5:04:21 PMRe: Arthritis What is DMSO please? Terri Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 8, 2009 Thanks. On Sat, Feb 7, 2009 at 7:54 PM, Hugh Ramsdell <hughman73 wrote: DiMethylSulfOxide T M <gettinghealthier Sent: Saturday, February 7, 2009 5:04:21 PM Re: Arthritis What is DMSO please? Terri Quote Share this post Link to post Share on other sites
Guest guest Report post Posted April 20, 2009 I tried CMO on my dog for quite awhile at one point for arthritis and didn't help at all, the only thing that has helped him was MSM & CS. Tammatha - Michael Goebel Butch Owen ; Oleander Soup Monday, April 20, 2009 8:24 AM Arthritis Hi, Butch and Group,I have arthritis throughout my entire spine. -- Too many motorcycle accidents!--I have used just about everything. One product stands out as clearly superior. It cannot be patented because it is natural. The product is called CMO, trans-ceramyl-9-cetyl myristoleate.CMO was discovered by Harry W. Diehl shortly before he retired from the National Institutes of Health. He could not produce arthritis in mice. This led to an extensive investigation of mice. He retired as he was doing this research. He continued in his home laboratory until he had extracted several fatty acids which mice genetically code and produce. Chief among these was CMO.He tried the extract on Rats, cats, dogs, monkeys, etc. Eventually his arthritic neighbors coerced him to let them try it. Each species had phenomenal success in response to CMO. The last reported data I have read said the of the folks who have taken CMO, 87% report complete, lasting relief, and the remaining 13% report very significant relief. (Compare that to a drug study!) The original protocol was to take one 500 mg capsule of CMO per day for 40 straight days. (I began to get relief from the 17th day forward.) I have not seen it fail to give total or near complete relief on any friend or patient who had tried it.One transmission mechanic with ankylosing spodylitis reported it had been the only things that had given him any relief in over 5 years.CMO is available from a number of distributors. My personal supply I use and resell comes from richdistributing.comI hope this post helps a lot of folks in the group.Michael L Goebel, DC, ACN Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 23, 2010 any ayurvedic cure for arthritis ?? Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 23, 2010 Smart boy keep your intestines clean, take a mild purgative once a week and fast once a week. not the kind of fast Indian women keep where they are off grains but eat the heaviest of food. Just be on juices. and the next day after the fast also go light on food. This is a vata dosh so see that vata is tackled. You may have two pods of raw garlic in the morning, you may also have quarter spoon of cinnamon powder awith a tea spoon of honey. Taking triphala benefits every one. Flaxseeds also help in arthritis and so does the water kept in a coppper container help if we drink that water. I am not a doctor but this is my practical experience through which I am writing this. ________________________________ any ayurvedic cure for arthritis ?? Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 23, 2010 Ayurveda offers the best of the management of Arthritis among the contemporary medical sciences. Kindly revert with the variety of Arthritis, one is suffering. Thanks & Regards, Dr.Deshpande www.phytoinc.com +91 96865 54464 +91 94480 09151 ________________ any ayurvedic cure for arthritis ?? Quote Share this post Link to post Share on other sites
Guest guest Report post Posted February 24, 2010 Malhotraji, Hari Om ! Respected Mridulaji Sharma & Dr. Sudheendraji Deshpande have suggested in right direction. There are over 100 different forms of arthritis. Irrespective of the type of arthritis, the common symptoms for all arthritis disorders include pain and a constant ache around the joint(s). The pain from arthritis occurs due to inflammation that occurs around the joint, damage to the joint from disease, daily wear and tear of joint, muscles strains caused by forceful movements against stiff, painful joints and fatigue. There is some evidence that consuming the commonly-eaten Nightshade plants (tomatoes, potatoes, eggplant, bell pepper family, and tobacco) is the causing factor in arthritis. In arthritis the joints become stiff and the range of movements is limited. Physical therapy can teach you how to relax the stiff joint and not damage the joint. Moreover, physical therapy can provide splints or braces for your joints. There are also assist devices available that can help you drive, getting a bath, dressing and also in housekeeping labors. Occupation therapy can teach you how to reduce stress on your joint from daily living activities. Occupation therapy can also teach you how to modify your home and work environment so that you do reduce movements that may worsen your arthritis. Studies have shown that physical exercise of the affected joint can have noticeable improvement in terms of long-term pain relief. Furthermore, exercise of the arthritic joint is encouraged to maintain the health of the particular joint and the overall body of the person. A few Asanas & Pranayams, if done regularly, are really helpful. There are many herbs which control arthritis disorders include pain and a constant ache around the joint(s) but it is difficult for a common man to prepare a mix of these herbs. So, take RUMALAYA tablets, product of The Himalaya Drug Company Limited, regularly for a few months alongwith a few Asanas & exercises suggested by Rev. Swami Ramdevji. Best wishes, Swami Brahmavidyananda Saraswati ___________ > any ayurvedic cure for arthritis ?? Quote Share this post Link to post Share on other sites