Now curcumin as an anti-malarial

[Guest guest]

, " "

<@e...> wrote:

> Hi Daniel & DM,

>

> > hello group, i would appreciate any specific experience or

> > reccomendations for prophelactic use of cm against malarial

infection?

> > thanks for your help, dm<<<

>

> Hello dm, There was a discussion on this list a few months back

and, if I

> remember correctly, there was some consensus that there may not be

any

> Chinese medicinals that could be used as prophylactic agents.

 

I just found this today. In another article about the same study

they combined curcumin, artemisinin and another anti-malarial drug.

Sounds like the beginnings of a formula. I haven't found the full

study yet.

Jill Likkel

 

Curcumin for malaria therapy

 

Raju C. Reddya, Palakkodu G. Vatsalab, Venkateshwar G. Keshamounia,

Govindarajan Padmanabanb and Pundi N. Rangarajanb, ,

 

aDepartment of Internal Medicine, The University of Michigan Medical

School, Ann Arbor, MI 48109-0360, USA

bDepartment of Biochemistry, Indian Institute of Science, Bangalore

560012, India

 

Received 9 November 2004. Available online 20 November 2004.

 

 

 

 

Abstract

Malaria remains a major global health concern. New, inexpensive, and

effective antimalarial agents are urgently needed. Here we show that

curcumin, a polyphenolic organic molecule derived from turmeric,

inhibits chloroquine-resistant Plasmodium falciparum growth in

culture in a dose dependent manner with an IC50 of 5 ìM.

Additionally, oral administration of curcumin to mice infected with

malaria parasite (Plasmodium berghei) reduces blood parasitemia by

80–90% and enhances their survival significantly. Thus, curcumin may

represent a novel treatment for malarial infection.

 

Keywords: Curcumin; Malaria; Plasmodium; Artemisinin

[Guest guest]

, " Jill A. Likkel "

<jilllikkel@h...> wrote:

>

>

> Curcumin for malaria therapy

>

> Raju C. Reddya, Palakkodu G. Vatsalab, Venkateshwar G.

Keshamounia,

> Govindarajan Padmanabanb and Pundi N. Rangarajanb, ,

>

> aDepartment of Internal Medicine, The University of Michigan

Medical

> School, Ann Arbor, MI 48109-0360, USA

> bDepartment of Biochemistry, Indian Institute of Science,

Bangalore

> 560012, India

 

 

I have the full article now if you want it email me.

Jill Likkel