Guest guest Posted March 20, 2008 Report Share Posted March 20, 2008 Pioneers of Pathology - Compiled by Dr. Apurva A. Tamhane (B.H.M.S., C.C.H., C.G.O.) Email: 123.apurva Hippocrates - 460 to 377 BC Father of Medicine Cornelius Celcus - 53 BC to 7 AD Described Rubor - Tumor - Dolor - Calor 's Stages of Inflammation Charak Samhita - Medicine Sushruta Samhita - Surgery Cladius Galen 130 to 200 AD Illness from Imbalance of Four Humors - Blood, Lymph, Black Bile (From Spleen), Bile Wrote 80 Books Theory of Vitalism – Life under Influence of Vital Substance under control of soul Artworks - 1452-1519 AD Vesalius Dissection - 1514 to 1564 Gabriel Fallopius - 1523 to 1562 AD Described Human Oviducts (Fallopian Tubes) Fabricius Described Lymphoid Tissue - Intestine of Birds (Bursa of Fabricius) Giovanni B. Morgagni 1682 to 1771 AD Italian Anatomist Pathologist Morbid Anatomy 700 Postmortems Clinicopathologic Correlation Sir Pervical Pott 1714 to 1788 AD England Surgeon Identified Occupational Cancers in Chimney Sweeps in 1775 AD and discovered Chimney Soot as a Carcinogenic Agent John Hunter (1728 to 1793) & William Hunter (1718 to 1788) Museum of Pathological Anatomy and Anatomy 13000 Surgical Specimen Hunterian Museum in England Work on Small Pox Inoculation Self Inoculation of Venereal Disease Xavier Bichat(1771 to 1802) Organs Compiled of Tissues Classified Pathology as General and Systemic Pathology Matthew Baillie 1760 to 1823 Wrote first Textbook on Pathology in 1793 R.T.H. Laennaec 1781 to 1826 French Physician Described Lung Diseases - Tubercles, Caseous Lesions, Miliary Lesions, Pleural Effusions, Bronchaectasis. Described Chronic Sclerotic Liver Disease - Laennaec's Cirrhosis Invented the Stethoscope. Carl F. Van Rokitansky 1804 to 1878 30,000 Autopsies Acute Yellow Atrophy of Liver Monograph on Diseases of Arteries & Congenital Heart Defects Book on Pathological Anatomy Guy Hospital, London, England Richard Bright 1789 to 1858 Non Suppurative Nephritis (Glomerulonephritis/Bright's Disease) Thomas Addison 1793 to 1860 Chronic AdrenoCortical Insufficiency (Addison's Disease) Thomas Hodgkin 1798 to 1866 Complex of Chronic enlargement of Lymph Nodes, often with enlargement of liver, spleen (Hodgkin's Disease) von Leeuwenhoek 1632 to 1723 Draper by Profession Invented Microscope Introduced Histological Staining in 1714 Marcello Malphigi 1624 to 1694 Presence of Capillaries Described Malphigian Layer of Skin Lymphoid tissue in Spleen (Malphigian Corpuscles) Father of Histology Louis Pasteur 1822 to 1895 French Chemist Showed the existence of Disease Causing Micro-organism using Microscope GHA Hansen 1841 to 1912 Hansen's Bacillus causative for Leprosy (Hansen's Disease) Edward Jenner Immune Tolerance & Allergy Basis of Immunisation Perkin in 1856 Use of Synthetic dyes for Staining Paul Ehrlich 1854 to 1915 German Physician Developed Ehrlich's test for Urobilinogen using Ehrlich's Aldehyde reagent Christian Gram 1853 to 1938 Danish Physician Bacteriologic Staining by Crystal Violet D L Romanowsky 1861 to 1921 Russian Physician Peripheral Blood Film Stain using Eosin and Methylene Blue derivatives Robert Koch 1843 to 1910 German Bacteriologist Koch's Postulate Koch's phenomena Techniques of Fixation Staining for Identification of Bacteria Discovered Tubercle Bacteria in 1882 Discovered Cholera Vibrio Organism in 1883 May GrunWald in 1902 and Giemsa in 1914 Developed Blood Stains Classification of Blood Cells Bone Marrow Cells Sir William Leishman 1865 to 1926 Leishman's Stain for Blood Films in 1914 Leishman-Donovan bodies (LD Bodies) in Leishmaniasis Robert Feulgen 1884 to 1955 Feulgen Reaction for Staining DNA Cytochemistry and Histochemistry Foundation Robert Hooke in 1667 Cork Cell Display F.T. Schwann 1810 to 1882 First Neurohistologist displayed Living Cells Claude Bernarde 1813 to 1878 Pathophysiology Rudolf Virchow 1821 to 1905 Beginning of Histopathology as a method of investigation by examination of diseased tissues at cellular level 2 Hypothesis 1. All cells come from other cells 2. Disease is an alteration of normal structure and function of these cells Father of Modern Pathology Cohnheim 1839 to 1884 Frozen Section Examination Karl Landsteiner 1863 to 1943 Existance of Human Blood Groups in 1901 Nobel Prize in 1930 Ruska & Lorries 1933 Developed the Electron Microscope George N Papanicolaou 1883 to 1962 Greek born American Pathologist in 1930s Development of Exfoliative Cytology for early detection of Cervical Cancer Tijo & Levan - 1956 Identification of Chromosomes & their Correct Number in humans Watson & Crick - 1953 Description of the structure of DNA of Cell Nowell - 1960 Identification of the Philadelphia Chromosome t(9;22) in Chronic Myeloid Leukaemia Hagerford - 1960 First Chromosomal Abnormality in any Cancer Barbara McClintock Flexibility & Dynamism of DNA Nobel Prize in 1983 Surgical Pathologists James Ewing - 1866 to 1943 Pierre Masson - 1880 to 1958 A.P. Stout - 1885 to 1967 Lauren Ackerman - 1905 to 1993 William Boyd Canadian Psychiatrist turned Pathologist Pathology for Surgeons - First Edition in 1925 Textbook of Pathology - First Edition in 1932 M.M. Witrobe Haematocrit technique www.healthverve.blogspot.com <http://www.healthverve.blogspot.com> Quote Link to comment Share on other sites More sharing options...
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