Guest guest Posted September 16, 2006 Report Share Posted September 16, 2006 Help us spread the word This broadcast is copyright-free. Please e-mail this on to any friends you think would appreciate receiving it. Better yet, get them to join the WDDTY community by registering on our website - www.wddty.co.uk - to receive their own E-bulletins twice a week. Thank you. News content COX-2 DRUGS: And then there was one CHILDHOOD CANCER: It increases every year, and pollution could be to blame CAESAREAN: It triples the death rate in newborns INJURY: Emergency drugs could be killing the patient COX-2 DRUGS: And then there was one How much longer can the COX-2 painkillers survive? There's just one version left on the market - Pfizer's Celebrex (celecoxib) - and that has been found to dramatically increase the risk of heart attack among cancer patients in a new study published last week. Industry pundits reckon it will soon go the way of Bextra (valdecoxib), which was withdrawn in 2005, and the notorious Vioxx (rofecoxib), which was voluntarily withdrawn by the manufacturer ahead of the costliest class action suit in American legal history. Celebrex is still being regularly used to ease arthritis and period pain - and it also slows the progress of bowel cancer. But when it was taken by a group of patients, the drug increased the risk of serious heart problems by more than three times, posing an unacceptable risk, researchers said. Another study of Celebrex among cancer patients came up with a similar result a year ago. Patients at highest risk were those taking the 400 mg daily dose, but even patients on half that dose still more than doubled their chances of developing heart problems. This seems to be a familiar pattern. Vioxx was withdrawn in 2004 because it was suspected of causing heart attack and stroke, and recent studies have found that the effect can happen even very shortly after starting the drug. Bextra, which is also manufactured by Pfizer, was withdrawn on the instructions of drug regulators because of similar concerns. Merck, Vioxx's manufacturer, has been paying millions of dollars to families of patients who died from a heart attack while taking the drug, and it's reckoned damages could reach into the billions. The COX-2s were designed to be a kinder and gentler version of the traditional NSAID (non-steroidal, anti-inflammatory drugs) painkillers. They were supposed to be just as effective, while overcoming the problems of the NSAIDs, which can cause ulcers and other stomach problems. But one study that compared the two painkillers in a large group of arthritis sufferers found that, after four years' usage, just as many patients were getting ulcers while on a COX-2 as those taking a traditional NSAID. That's if they didn't die from a heart attack in the meantime, presumably. (Source: New England Journal of Medicine, 2006; 355: 873-84). CHILDHOOD CANCER: It increases every year, and pollution could be to blame Is our polluted environment giving our children cancer? Cancer among children throughout Europe has been increasing by 1 per cent every year for the last 20 years - and toxic agents in our environment are the most likely cause. Researchers who made the discovery say that the increase is too high, and consistent, to be blamed on the usual excuse of better diagnosis. Instead, changes in our lifestyle, diet and 'exposure to a variety of agents' are the most likely causes. The researchers tracked the cancer rates in children, aged below 14 years, in 15 European countries from 1978 to 1997. In 1978, just 120 children per million were developing cancer, but, in 1997, the rate had increased to 141 cases per million. The rate increased by an average of 1.1 per cent each year. The trend was similar across every country and across every type of cancer, with leukaemia being by far and away the most common. Of course, it could also be down to the enormous successes seen in medical advance, the researchers surmise. Because of the wonders of medicine, women with poor genes were surviving and passing on their weak genes to their offspring. Yeah, right. (Source: European Journal of Cancer, 2006; 42: 1961). CAESAREAN: It triples the death rate in newborns Babies born by Caesarean section are three times more likely to die soon afterwards than those born naturally, a new study has discovered. The neonatal death rate among babies born naturally is just 0.62 per 1,000 births, but that rate leaps to 1.77 deaths among babies born by Caesarean. Neonatal rates are measured for the first 28 days after birth. The findings may put a sudden halt to the increases in elective Caesarean deliveries, which are those where the women chooses to have the procedure even when there is no good medical reason for it. In 2003 in America, nearly 28 per cent of all births were by Caesarean section while the rate is only slightly lower in the UK. Of these around 16 per cent are first-time Caesareans, and the remainder is made up of women who previously had a Caesarean, giving weight to the idea of 'once a Caesarean, always a Caesarean'. A Caesarean section is a major abdominal operation that should be performed only when either the mother or the baby is at risk. The World Health Organization reckons that no country should have a Caesarean rate greater than 10 per cent of all births, which should cover all necessary interventions. Researchers of the new study surmise that a natural birth helps squeeze fluids from the newborn's lungs, while the process also releases hormones that help establish healthy lungs. (Source: Birth, 2006; 33: 175). INJURY: Emergency drugs could be killing the patient Hospital accident and emergency units are routinely treating injuries with untested therapies that may kill the patient, a leading consultant has said. Professor Ian Roberts at the London School of Hygiene and Tropical Medicine says that virtually no treatment for emergency trauma care has been tested for its safety. Pharmaceutical companies spend just a fraction of their research funding on injury care, instead preferring to concentrate on cancer and heart disease. The use of corticosteroids for head injury in hospitals was stopped only after a study in 2004 discovered that they significantly increased the risk of death. Prof Roberts described the effects of the drug as 'industry slaughter'. This 'black hole' in research means that doctors have no way of knowing if other dugs are similarly dangerous, Prof Roberts told the British Association for the Advancement of Science conference this week. (Source: The Times, 7 September 2006). Listen to Lynne On the radio: Hear Lynne McTaggart on Passion the innovative DAB Digital Radio Station focusing on your health and your environment - http://www.wddty.co.uk/passion_main.asp On demand: Select and listen to any of Lynne's archived broadcasts on Passion, there's a new one each week - http://www.wddty.co.uk/passion_archive.asp Help us spread the word If you can think of a friend or acquaintance who would like a FREE copy of What Doctors Don't Tell You, please forward their name and address to: info. 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