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Dear All,

 

I have also heard that curcumin is being researched to treat

Alzheimer's disease. I searched the internet for supportive

information - I found this tidbit on Wikipedia.

 

Many thanks for posting the article about curcumin being used to

treat depression - it was very interesting....

 

Respectfully, Danamarie

 

*****

 

From Wikipedia, the free encyclopedia

 

Curcumin is the active ingredient of the Indian curry spice

turmeric. It is a polyphenol with a molecular formula C21H20O6.

Curcumin can exist in at least two tautomeric forms, keto and enol.

The keto form is preferred in solid phase and the enol form in

solution.

 

Curcumin is known for its antitumor, antioxidant, anti-amyloid and

anti-inflammatory properties. For the last few decades, extensive

work has been done to establish the biological activities and

pharmacological actions of curcumin. Its anticancer effects stem

from its ability to induce apoptosis in cancer cells without

cytotoxic effects on healthy cells. A 2004 UCLA-Veterans Affairs

study involving genetically altered mice suggests that curcumin

might inhibit the accumulation of destructive beta-amyloid in the

brains of Alzheimer's disease patients and also break up existing

plaques associated with the disease. It was published that curcumin

inhibits cyclooxygenase-2 (COX-2) as well as lipoxygenase (LOX), two

enzymes involved in inflammation.

 

It is used as a food coloring. As a food additive, its E number is

E100.

 

*****

 

References

Chemopreventive properties of curcumin. Campbell, Frederick C.;

Collett, Gavin P. Future Oncology (2005), 1(3), 405-414.

 

 

A potential role of the curry spice curcumin in Alzheimer's disease.

Ringman, John M.; Frautschy, Sally A.; Cole, Gregory M.; Masterman,

Donna L.; Cummings, Jeffrey L. Current Alzheimer Research (2005), 2

(2), 131-136.

 

 

Curcumin derived from turmeric (Curcuma longa): A spice for all

seasons. Aggarwal, Bharat B.; Kumar, Anushree; Aggarwal, Manoj S.;

Shishodia, Shishir. Phytopharmaceuticals in Cancer Chemoprevention

(2005), 349-387.

 

 

Turmeric and curcumin: biological actions and medicinal

applications. Chattopadhyay, Ishita; Biswas, Kaushik; Bandyopadhyay,

Uday; Banerjee, Ranajit K. Current Science (2004), 87(1), 44-53

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Elevated mood can hurt, it's a euphemism for mania. Bipolar clients do

themselves the most harm in this phase because they don't think anything

is wrong.

 

Becky wrote:

 

>fyi

> This isn't TCM, but a supplement can be used for depression, called

> S-Adenosylmethionine (SAMe),

> http://www.umm.edu/altmed/ConsSupplements/SAdenosylmethionineSAMecs.html

> something our bodies make in small quantities. It also comes from certain

foods.

>

> I was interested because it is good for the liver; and an elevated mood

couldn't hurt ;) I tried it in September, at half dose because it warns of a

side effect of feeling 'elated'. It is also used to treat depression. The 1st

time I took it I felt different, like a clear-minded high, and my walk at the

trail on the lake was all smiles and energetic. The remaining doses sort of

blended together without any change in mood (at half dose).

>

> I quit taking it because it creates homocystein, which in excess is harmful,

and I was already supplementing with a methyl doner, without knowing that

methionone loading is possible in excess. The sulfer-based processes can make

you acidic by forming a very mild sulfuric-acid-type solution in the blood,

which can corrode blood vessels and leech calcium from bones, in high doses.

Some B vitamins are methyl doners; another reason not to megadose on vitamins!

Some things are necessary but in small doses.

>

> My ph was already noted at 5 prior to starting a supplements regimine, so I

stopped all methyl doners, including sam-e. I still have some left and

occasionally I've taken one, but I don't feel any different with it. Only the

1st time did I feel somewhat elevated.

>

>

>das4145 <asenat45 wrote:

> Dear All,

>

>I have also heard that curcumin is being researched to treat

>Alzheimer's disease. I searched the internet for supportive

>information - I found this tidbit on Wikipedia.

>

>Many thanks for posting the article about curcumin being used to

>treat depression - it was very interesting....

>

>Respectfully, Danamarie

>

>*****

>

>>From Wikipedia, the free encyclopedia

>

>Curcumin is the active ingredient of the Indian curry spice

>turmeric. It is a polyphenol with a molecular formula C21H20O6.

>Curcumin can exist in at least two tautomeric forms, keto and enol.

>The keto form is preferred in solid phase and the enol form in

>solution.

>

>Curcumin is known for its antitumor, antioxidant, anti-amyloid and

>anti-inflammatory properties. For the last few decades, extensive

>work has been done to establish the biological activities and

>pharmacological actions of curcumin. Its anticancer effects stem

>from its ability to induce apoptosis in cancer cells without

>cytotoxic effects on healthy cells. A 2004 UCLA-Veterans Affairs

>study involving genetically altered mice suggests that curcumin

>might inhibit the accumulation of destructive beta-amyloid in the

>brains of Alzheimer's disease patients and also break up existing

>plaques associated with the disease. It was published that curcumin

>inhibits cyclooxygenase-2 (COX-2) as well as lipoxygenase (LOX), two

>enzymes involved in inflammation.

>

>It is used as a food coloring. As a food additive, its E number is

>E100.

>

>*****

>

>References

>Chemopreventive properties of curcumin. Campbell, Frederick C.;

>Collett, Gavin P. Future Oncology (2005), 1(3), 405-414.

>

>

>A potential role of the curry spice curcumin in Alzheimer's disease.

>Ringman, John M.; Frautschy, Sally A.; Cole, Gregory M.; Masterman,

>Donna L.; Cummings, Jeffrey L. Current Alzheimer Research (2005), 2

>(2), 131-136.

>

>

>Curcumin derived from turmeric (Curcuma longa): A spice for all

>seasons. Aggarwal, Bharat B.; Kumar, Anushree; Aggarwal, Manoj S.;

>Shishodia, Shishir. Phytopharmaceuticals in Cancer Chemoprevention

>(2005), 349-387.

>

>

>Turmeric and curcumin: biological actions and medicinal

>applications. Chattopadhyay, Ishita; Biswas, Kaushik; Bandyopadhyay,

>Uday; Banerjee, Ranajit K. Current Science (2004), 87(1), 44-53

>

>

>

>

>

>

>

>

>

>

>

>Post message: Chinese Traditional Medicine

>Subscribe: Chinese Traditional Medicine-

>Un: Chinese Traditional Medicine-

>List owner: Chinese Traditional Medicine-owner

>

>Shortcut URL to this page:

>/community/Chinese Traditional Medicine

>

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Chinese Traditional Medicine , Becky <bsalibrici> wrote:

>

> Can't they be reasoned with? I know very little about it, but if

you are feeling great it should be tied to what is going on in your

life, in addition to one's basic personality/metabolism. If you are

feeling great while serious issues are falling apart around you

don't regard ... then mania? Sometimes one should be bummed because

of circumstances, but if you are depressed and everything around you

is actually fine ... then mania?

 

In TCM any emotion taken to extremes is a sign of problems and also

a creator of problems. It goes back to the way improperly handled

emotions can trigger certain imbalances, but once an Organ is

imbalanced from whatever cause (trauma, viral, toxin, bacterial,

fungal, etc., the person is going to be more prone to feeling the

particular emotion than before. (A reminder to those new to TCM

that TCM Organs are not equivalent to anatomical organs. TCM Organs

are defined as collections of functions.)

 

The TCM Organ most vulnerable to mania is the Heart. The textbooks

usually use the term " joy " , but that's a poor translation. Mania is

a closer translation. Obviously some joy can be good for the heart

and the Heart, but mania is something else.

 

The psychoses have a Root of severe Heart imbalance. Phlegm Fire

Harassing the Heart or Phlegm Misting the Mind. Phlegm Fire in

particular, and it can manifest as either depression or mania or

both alternating.

 

But the psychological symptoms are only a part of the picture. If

left untreated, these imbalances also have some severe physical

manifestions. Things like heart disease, a tendency to stroke,

coma, etc.

 

The goal of TCM is not the eradication of emotions but the wise use

and processing of emotions. Sometimes emotions can be very helpful

and even life-saving. Like when fear gets one to move away from a

threat. Justified anger that causes a person to demand changes for

the better. Etc. Self-confidence can be a good thing. It can get a

person to reach for things that the person can obtain. But mania is

different. It can cause people to be reckless to the point of

endangering their financial security or even their lives.

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<snip>

> I quit taking it because it creates homocystein,

> which in excess is harmful, and I was already

> supplementing with a methyl doner, without

> knowing that methionone loading is possible

> in excess. The sulfer-based processes can make

 

Chemical constituents?

We're thinking like Westerners here aren't we.

 

I'm not saying that's wrong.

Its good to use knowledge as it applies.

 

and in this case, your Western science knowledge

of chemical constituents came in handy.

 

However, I've heard it said that 80% of those who

use herbs in the USA are self medicating without

any reason other than they heard some herb was

good for something.

 

I don't fault Western medical doctors for freaking

out about herbs because they get to see all the

people when a bad adventure happens from those

self prescribed herbs.

 

Its been said on this list before, many times its not

a matter of adding something to one's lifestyle.

 

Its more a case of stopping a behaviour that isn't

benefitial.

 

We reflect our energetic state.

We choose our course of action influenced by our

energetic state.

Our state of balance or imbalance is from where

we make our decisions.

 

This is why its a good idea to have a personal policy

of hiring consultants.

Consultants (Western or Eastern) are paid to give

you the benefit of their impartial education.

 

They are only hired help.

In the end we all have to accept that they aren't living

in our bodies and its us who need to accept

responsibility for it.

 

I think its very good when someone can approach herbs

by their chemical constituents.

 

However, if one reads " The Web That Has No Weaver "

they'll realize that skill as not one included in the

theories of .

 

While it is good to know therapies exist based on

chemical constituents, answers to those questions

might be better answered on an e list that focuses

on that kind of approach to therapy.

 

Chinese herbal medicine would rarely used an herb

as a what Western herbalism would call a " simple "

(one at a time).

Instead, they use herbs in complex formulas to

balance out the good or not so good aspects of the

various herbs and how they apply to the individual

ingesting them.

 

Turmeric (jiang huang) curcuma longa, the part used

is the rhizome.

Its qualities are cool, acrid and bitter.

The organ systems its qualities most affect are said

to be the Liver (yin Wood), Gallbladder (yang wood) and

Heart (absolute Fire).

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Belief systems are more than half the problem or the solution in

many cases; see Andrea Yates, she was influenced by an extremist

'christian' teaching that " bad mothers go to hell and thair bad

children will follow them " (eve's falt), and she confessed she

killed her five children because,(in her deliriums) she was being

a bad mother and they where 'going wrong'. Now, i don't think

there has ever been in human history a worse, meaner and falser

lie than this story of " original sin " .

People get sick or well according to what they believe. " Mind

over Matter " . If the patient has empathy and trusts the

healer/doctor, it is half the battle! (at the least he will

follow prescriptions).

If we believe we are basically sick(or sinful), all the worse for

us. If we believe we are basically healthy, good for us then!

In the Taoist view of health, Harmony is the Golden Rule.

 

Marcos

 

-- Zenisis <findme escreveu:

 

(.....)

> Or look at Andrea Yates. From a psichiatric point of view

> those

> children's deaths could have been prevented if she had the

> proper meds

> and support. But her husband didn't believe in that--he told

> her should

> would just have to be " strong " .

> (.....)

>> Zen

>

> >

 

 

 

 

 

 

 

 

_____

doce lar. Faça do sua homepage.

http://br./homepageset.html

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Don't forget that Yu Jin and E Zhu are also in the tumeric family with slightly

differerent properties.

Bob

www.acuherbals.com

 

Penel <hyldemoer wrote:

<snip>

> I quit taking it because it creates homocystein,

> which in excess is harmful, and I was already

> supplementing with a methyl doner, without

> knowing that methionone loading is possible

> in excess. The sulfer-based processes can make

 

Chemical constituents?

We're thinking like Westerners here aren't we.

 

I'm not saying that's wrong.

Its good to use knowledge as it applies.

 

and in this case, your Western science knowledge

of chemical constituents came in handy.

 

However, I've heard it said that 80% of those who

use herbs in the USA are self medicating without

any reason other than they heard some herb was

good for something.

 

I don't fault Western medical doctors for freaking

out about herbs because they get to see all the

people when a bad adventure happens from those

self prescribed herbs.

 

Its been said on this list before, many times its not

a matter of adding something to one's lifestyle.

 

Its more a case of stopping a behaviour that isn't

benefitial.

 

We reflect our energetic state.

We choose our course of action influenced by our

energetic state.

Our state of balance or imbalance is from where

we make our decisions.

 

This is why its a good idea to have a personal policy

of hiring consultants.

Consultants (Western or Eastern) are paid to give

you the benefit of their impartial education.

 

They are only hired help.

In the end we all have to accept that they aren't living

in our bodies and its us who need to accept

responsibility for it.

 

I think its very good when someone can approach herbs

by their chemical constituents.

 

However, if one reads " The Web That Has No Weaver "

they'll realize that skill as not one included in the

theories of .

 

While it is good to know therapies exist based on

chemical constituents, answers to those questions

might be better answered on an e list that focuses

on that kind of approach to therapy.

 

Chinese herbal medicine would rarely used an herb

as a what Western herbalism would call a " simple "

(one at a time).

Instead, they use herbs in complex formulas to

balance out the good or not so good aspects of the

various herbs and how they apply to the individual

ingesting them.

 

Turmeric (jiang huang) curcuma longa, the part used

is the rhizome.

Its qualities are cool, acrid and bitter.

The organ systems its qualities most affect are said

to be the Liver (yin Wood), Gallbladder (yang wood) and

Heart (absolute Fire).

 

 

 

 

 

 

 

 

 

 

 

 

Post message: Chinese Traditional Medicine

Subscribe: Chinese Traditional Medicine-

Un: Chinese Traditional Medicine-

List owner: Chinese Traditional Medicine-owner

 

Shortcut URL to this page:

/community/Chinese Traditional Medicine

 

 

 

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E Zhu is Curcuma Zedoaria and Yu Jin is Curcuma Aromatica

Bob

www.acuherbals.com

 

Penel <hyldemoer wrote:

Hi Bob,

I don't doubt you.

What are the (Latin) botanical names of Yu Jin and E Zhu?

 

> Don't forget that Yu Jin and E Zhu are also in the

> tumeric family with slightly differerent properties.

> Bob

> www.acuherbals.com

 

 

 

 

 

 

 

 

 

Post message: Chinese Traditional Medicine

Subscribe: Chinese Traditional Medicine-

Un: Chinese Traditional Medicine-

List owner: Chinese Traditional Medicine-owner

 

Shortcut URL to this page:

/community/Chinese Traditional Medicine

 

 

 

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Chinese Traditional Medicine , Zenisis <findme@z...> wrote:

 

> I am limited by geography for the school I will attend and I doubt that

> they emphasize five element theory. I will ask at orientation on

> Tuesday. But I am thinking I will have to study on my own or seek

> additional training on five elements after I graduate. Although

they do

> have continuing education classes on pschiatric disorders, perhaps

that goes into five elements.

 

In the meanwhile, you could check out the book Dragon Rises, Red Bird

Flies by Leon Hammer - it explores pyschology and . I

think Victoria recommended it here, and I was lucky enough to stumble

across a (barely) used copy for only $5.

 

sue

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Re: Re: Turmeric (curcumin)....

 

-lest we forget that PROZAC and its ilk is implicated in the vast majority of

suicides & homicides. If anyone has read the shocking & v.sad, 'Talk back to

Prozac',

http://www.breggin.com/prbbooks.html

the jigsaw pieces all fall into place...my mom wanted to take prozac back in

1988, when it came onto the market. The side effects were listed in the CPS

[compendium of pharmaceutecal substances]:suicde,delusional thoughts back then.

BigPharma/FDA knew it was deadly... but with $2.5 billion projected sales...

 

-from Dr.Breggin:

 

The FDA Continues to Affirm Antidepressant Risks

 

First Identified in my 1991 Book Toxic Psychiatry

 

By Peter R. Breggin, M.D.

 

Ithaca, New York

 

www.breggin.com

 

In 2004 the FDA issued a black box warning about the increased risk of

suicidality in children taking the newer antidepressants, including the SSRIs

(Prozac, Zoloft, Paxil, Luvox, Celexa, and Lexapro) and also Effexor and

Wellbutrin (also marketed as Zyban). On June 30, 2005 the FDA published a Public

Health Advisory warning of the possibility of increased suicidality in adults

treated with antidepressants. The FDA followed this on July 1, 2005 with a Talk

Paper elaborating on the potential risk and the agency’s plans to study the

problem further. All of these documents are available on www.fda.gov.

 

The FDA should have issued these warnings at least a decade ago. I first began

writing about antidepressant-induced suicidality in 1991. At that time I

identified drug-induced suicidality as part of a much larger

problem—antidepressant-induced activation or stimulation similar to that caused

by amphetamine, methamphetamine and cocaine. Antidepressant stimulation can lead

to violence as well as suicide and a wide variety of abnormal and even psychotic

behaviors.

 

Prozac was introduced to the American public in January 1988. Three years later

in my book Toxic Psychiatry (St. Martin’s Press, New York, 1991) was published.

In that book, as well as in many later books and scientific articles, I made the

following points:

 

All of the newer antidepressants can stimulate the brain. The results of

stimulation are similar to the effects of amphetamine, methamphetamine,

methylphenidate, and cocaine. Stimulating the brain leads to anxiety, agitation,

irritability, insomnia, disinhibition (loss of self-control), emotional lability

(instability), akathisia (agitation with hyperactivity), hostility, aggression,

and mania.

 

Especially in people who are already depressed, these over-stimulated reactions

can lead to a severe worsening of depression or to transformation of the

depression into mania. These effects can cause suicide and violence toward

others.

 

After I described the risk of antidepressant-induced stimulation in 1991, I

further developed the concept in subsequent books, including Talking Back to

Prozac (1994), Brain-Disabling Treatments in Psychiatry (1997), Your Drug May Be

Your Problem (1999, with David Cohen) and the Antidepressant Fact Book (2001). I

have also testified to the same principles in numerous malpractice, product

liability, and criminal cases involving antidepressant-caused suicidality,

violence, and varied severe abnormal behaviors. Long before the FDA came around

to agreeing with me, the courts have found sufficient scientific merit to my

arguments to allow them to be expressed at trials, including product liability

cases against the manufacturers of these drugs. The vast majority of these cases

against drug companies were settled before going to trial.

 

Shortly before the FDA met in 2004 to consider antidepressant-induced

suicidality in children, I wrote a peer-reviewed scientific article that was

simultaneously published in Ethical Human Sciences and Services and the

International Journal of Risk and Safety in Medicine (available on

www.breggin.com). My paper drew together all of the available scientific

evidence that the newer antidepressants cause a stimulant or activation syndrome

that can drive a person toward suicide or murder. I used scientific concepts and

language in this paper that were subsequently adopted by the FDA:

 

Mania with psychosis is the extreme end of a stimulant continuum that often

begins with lesser degrees of insomnia, nervousness, anxiety, hyperactivity and

irritability and then progresses toward more severe agitation, aggression, and

varying degrees of mania. (Breggin 2003/4, p. 32; obtainable on

www.breggin.com).

 

I also discussed in detail the risk of akathisia (agitation with hyperactivity)

as a cause of violence and suicide.

 

On March 22, 2004 the FDA published a Talk Paper entitled, " FDA Issues Public

Health Advisory on Cautions for the Use of Antidepressants in Adults and

Children. " The advisory focused on adults as well as children and stated:

 

The agency is also advising that that these patients be observed for certain

behaviors that are known to be associated with these drugs, such as anxiety,

agitation, panic attacks, insomnia, irritability, hostility, impulsivity,

akathisia (severe restlessness), hypomania, and mania.

 

This FDA statement is interchangeable with many that I have made in the

literature and in the courtroom.

 

The FDA describes these adverse reactions as " known " —that is, scientifically

demonstrated or established. The list confirms the existence of the

antidepressant-induced stimulant effect or activation syndrome in adults and

children with its potential to cause hostility and related behaviors. The FDA

has gone on to require drug manufacturers to include these

antidepressant-induced adverse effects in their FDA-approved labels for the

drugs. The FDA label for antidepressants (revised January 26, 2005) requires the

following statement about activation or stimulation in children and adults:

 

The following symptoms, anxiety, agitation, panic attacks, insomnia,

irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor

restlessness), hypomania, and mania have been reported in adult and pediatric

patients being treated with antidepressants for major depressive disorder as

well as other indications.

 

Simultaneously, the FDA compelled the drug companies to include a specific

warning about the increased risk of suicidality in children taking

antidepressants. This warning has received the most attention in the media and

the medical profession. However, FDA recognition of the stimulant or activation

syndrome, including the production of increased agitation, irritability,

impulsivity, hostility, aggressiveness, and mania is in many ways more

important. Over-stimulation is far more common than suicidality and causes not

only suicidality but also violence and an endless variety of destructive,

impulsive behaviors.

 

The adverse effects described by the FDA are almost identical to mine,

suggesting that they paid attention to my publications and to my testimony

before the agency on two occasions in 2004 (obtainable on www.breggin.com).

Also, the FDA’s has followed my method of organizing these specific adverse

effects into one group that can be viewed as stimulation or activation. I have

written in some detail about the implications of recent regulatory changes in

regard to antidepressants that have occurred in the U.S., Canada and Great

Britain.

 

The FDA has continued to affirm the points I first made in 1991 in Toxic

Psychiatry. On June 30, 2005, the FDA issued another Public Health Advisory,

this time aimed more specifically at adults, entitled, " Suicidality in Adults

Being Treated with Antidepressant Medications. " The FDA announced the beginning

of a lengthy review of the subjected and in the meanwhile warned:

 

Adults being treated with antidepressant medications, particularly those being

treated for depression, should be watched closely for worsening of depression

and for increased suicidal thinking or behavior.

 

On July 1, 2005 the FDA issued an FDA Talk Paper on the same subject. It

emphasized another point that I have been making in my books and articles, and

in court, for many years:

 

Close observation of adults may be especially important when antidepressant

medications are started for the first time or when doses for the specific drugs

prescribed have been changed.

 

I have been consulted in dozens of malpractice and product liability cases in

which patients have committed suicide or perpetrated violence against others

shortly after starting antidepressants or shortly after dose changes.

 

Naturally, it is gratifying to have the scientific literature and the FDA

confirm observations that I have made, at some professional cost, for many

years. It is satisfying to see views once labeled radical and controversial

become centerpieces of establishment drug regulation. On the other hand, it is

frustrating and even tragic that there has been such a long delay in coming to

grips with drug-induced problems that have resulted in innumerable acts of

suicide and violence. Furthermore, medical professionals, especially my

colleagues in psychiatry, continue to resist and even to ignore the scientific

evidence and the warnings from the FDA. The FDA itself has shown no willingness

to take the next step—to ban these largely ineffective and highly dangerous

agents.

http://www.breggin.com/Breggin%20response%20to%207%5B1%5D.1.05%20FDA%20adult%20s\

uicide%20warnings.htm

 

 

 

 

 

marcos <ishk18

wrote

Belief systems are more than half the problem or the solution in

many cases; see Andrea Yates, she was influenced by an extremist

'christian' teaching that " bad mothers go to hell and thair bad

children will follow them " (eve's falt), and she confessed she

killed her five children because,(in her deliriums) she was being

a bad mother and they where 'going wrong'. Now, i don't think

there has ever been in human history a worse, meaner and falser

lie than this story of " original sin " .

People get sick or well according to what they believe. " Mind

over Matter " . If the patient has empathy and trusts the

healer/doctor, it is half the battle! (at the least he will

follow prescriptions).

If we believe we are basically sick(or sinful), all the worse for

us. If we believe we are basically healthy, good for us then!

In the Taoist view of health, Harmony is the Golden Rule.

 

Marcos

 

-- Zenisis <findme escreveu:

 

(.....)

 

>> Or look at Andrea Yates. From a psichiatric point of view

>> those

>> children's deaths could have been prevented if she had the

>> proper meds

>> and support. But her husband didn't believe in that--he told

>> her should

>> would just have to be " strong " .

>> (.....)

>

>

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