Effect of the Mediterranean Diet on Fasting Concentrations of Activated Factor VII in Healthy Persons

[Guest guest]

Effect of the Mediterranean Diet on Fasting Concentrations of Activated Factor

VII in Healthy Persons

JoAnn Guest

Mar 23, 2005 12:01 PST

=======================================================================

Effect of the Mediterranean Diet on Fasting Concentrations of Activated

Factor VII in Healthy Persons.

 

[Article in English, Spanish]

 

Gomez P, Fernandez de la Puebla RA, Castro P, Lopez-Miranda J, Marin C,

Fuentes F, Perez-Martinez P, Velasco F, Moreno JA, Torres A,

Perez-Jimenez F.

 

Unidad de Lipidos y Arteriosclerosis. Servicio de Medicina Interna.

Hospital Universitario Reina Sofia. Cordoba. Espana.

 

Introduction and objectives. Many clinical and epidemiologic studies

suggest that activated factor VII may be involved in the pathogenesis of

coronary heart disease. Our objective was to determine the effect of a

Mediterranean diet on plasma levels of activated factor VII in

comparison to a low-fat diet and a diet rich in saturated fat. Patients

and method. The study population comprised 16 healthy normolipemic men

who consumed 3 different diets in consecutive 28-day periods.

 

The first diet was rich in saturated fat (38% calories as fat, 20%

saturated fat), the second was a low-fat, high-carbohydrate diet (28%

calories as fat, 10% saturated fat), and the third was enriched in

monounsaturated fatty acids (38% calories as fat, 22% monounsaturated

fat).

 

At the end of each period, plasma concentrations of total cholesterol,

HDL cholesterol, LDL cholesterol, total triglycerides, apolipoprotein

A-I, apolipoprotein B, and glucose were measured. Activated factor VII

was determined with a coagulation assay.

 

RESULTS. The diet rich in saturated fat was associated with a

significant increase in total cholesterol, LDL cholesterol,

apolipoprotein AI, and apolipoprotein B in comparison to the other 2

diets. There were no significant differences between the

carbohydrate-rich diet and the Mediterranean diet in any of the lipid

parameters.

 

The Mediterranean diet decreased plasma levels of factor VIIa in

comparison to the diet rich in saturated fat (34.6+/-15.3 mU/mL vs

101.5+/-19.2 mU/mL; P<.05).

 

CONCLUSIONS. In comparison to the diet rich in saturated fat or the

high-carbohydrates diet, the Mediterranean diet decreased plasma

concentrations of activated factor VII in healthy young men.

 

This phenomenon may constitute another protective mechanism of the

Mediterranean diet in reducing cardiovascular risk.

 

PMID: 15766451 [PubMed - as supplied by publisher]

_________________

 

JoAnn Guest

mrsjo-

DietaryTi-

www.geocities.com/mrsjoguest/Genes

 

 

 

 

AIM Barleygreen

" Wisdom of the Past, Food of the Future "

 

http://www.geocities.com/mrsjoguest/Diets.html