Comprehensive Nutritional Status in Patients with Crohn Disease

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Medical Abstract Title:

 

Comprehensive Nutritional Status in Patients with Long-standing

Crohn Disease Currently in Remission

Author:

Geerling BJ, Badart-Smook A, Stockbrugger RW, Brummer RJ

Source:

Am J Clin Nutr. 1998; 67(5):919-926.

 

Abstract:

 

Malnutrition is observed frequently and is an important

complication in patients with Crohn disease (CD).

The pathophysiology of malnutrition in this disorder is complex.

 

To obtain a comprehensive picture of nutritional status in patients

with long-standing CD that was clinically in remission, we assessed

four measures of nutritional status in 32 patients (18 women and 14

men) and 32 matched healthy control subjects:

1) body composition, 2) dietary intake, 3) biochemical indexes of

nutrition, and 4) muscle strength (as a functional index).

 

Mean daily intakes of fiber and phosphorus were significantly lower

in CD patients than in control subjects.

 

Serum concentrations of several nutrients (beta-carotene, vitamin C,

vitamin E, selenium, and zinc)

and activity of the enzyme glutathione peroxidase were also

significantly lower in CD patients, as were antioxidant status and

serum concentrations of magnesium and vitamin D.

 

Percentage body fat and hamstring muscle strength were significantly

lower in male CD patients than in control subjects, whereas muscle

strength of the quadriceps was preserved.

 

In conclusion, this study showed a variety of nutritional and

functional deficiencies in patients with long-standing CD in

remission, especially in male patients with a high lifetime

prednisone dose.

 

A comprehensive nutritional assessment seems superior to the

assessment of a single dimension of nutritional status.

 

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