Fwd: Fluoride Exposure harms reproduction in human cells

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Subj: Fluoride-induced disruption of reproductive hormones in men.

7/17/2003 8:39:36 AM Eastern Standard Time

NYSCOF

 

 

 

" The results obtained indicate that a fluoride exposure of 3-27mg/day induces a

subclinical reproductive effect that can be explained by a fluoride-induced

toxic effect in both Sertoli cells and gonadotroph "

 

Environ Res. 2003 Sep;93(1):20-30. Related Articles, Links

 

Fluoride-induced disruption of reproductive hormones in men.

 

Ortiz-Perez D, Rodri;guez-Marti;nez M, Marti;nez F, Borja-Aburto VH, Castelo J,

Grimaldo JI, de la Cruz E, Carrizales L, Di;az-Barriga F.

 

Laboratorio de Toxicologi;a Ambiental, Facultad de Medicina, Universidad

Autonoma de San Luis Potosi;, Av. Venustiano Carranza 2405, Col. Lomas Filtros,

CP 78210, San Luis Potosi;, Mexico

 

Fluoride-induced reproductive effects have been reported in experimental models

and in humans. However, these effects were found in heavily exposed scenarios.

Therefore, in this work our objective was to study reproductive parameters in a

population exposed to fluoride at doses of 3-27mg/day (high-fluoride-exposed

group-HFEG). Urinary fluoride levels, semen parameters, and reproductive

hormones in serum (LH, FSH, estradiol, prolactin, inhibin-B, free and total

testosterone) were measured. Results were compared with a group of individuals

exposed to fluoride at lower doses: 2-13mg/day (low-fluoride-exposed

group-LFEG). A significant increase in FSH (P<0.05) and a reduction of

inhibin-B, free testosterone, and prolactin in serum (P<0.05) were noticed in

the HFEG. When HFEG was compared to LFEG, a decreased sensitivity was found in

the FSH response to inhibin-B (P<0.05). A significant negative partial

correlation was observed between urinary fluoride and serum levels of inhibin-B

(r=-0.333, P=0.028) in LFEG. Furthermore, a significant partial correlation was

observed between a chronic exposure index for fluoride and the serum

concentrations of inhibin-B (r=-0.163, P=0.037) in HFEG. No abnormalities were

found in the semen parameters studied in the present work, neither in the HFEG,

nor in the LFEG. The results obtained indicate that a fluoride exposure of

3-27mg/day induces a subclinical reproductive effect that can be explained by a

fluoride-induced toxic effect in both Sertoli cells and gonadotrophs.

 

PMID: 12865044 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2865044 & dopt=Abstract

 

 

New York State Coalition Opposed to Fluoridation

http://www.orgsites.com/ny/nyscof

http://tinyurl.com/ad9k

 

Fluoride Action Network

http://www.fluoridealert.org

 

 

 

 

 

 

 

 

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