Guest guest Posted May 7, 2003 Report Share Posted May 7, 2003 HSI - Jenny Thompson <hsiweb wrote: Tue, 6 May 2003 12:40:05 -0500 HSI - Jenny Thompson Getup'n'Gone GETUP'N'GONE Health Sciences Institute e-Alert May 6, 2003 ************************************************************** Dear Reader, If you're a man who's over the age of, say, 45, and you don't feel quite as young or strong or virile as you used to, a pharmaceutical company named Unimed wants to " raise your awareness " about male menopause. But don't worry – they have a remedy all ready for you: testosterone replacement therapy (TRT). Sure, it's going to cost you. And sure, you'll run the risk of adverse side effects. But if you want to aggressively run and jump like you did when you were half your present age, then you'll have to pay the piper. Or that's what Unimed (playing the role of the piper) would strongly encourage you to believe. There is a better way to go, but first we'll take a look at the Unimed plan. ----------------------------- Things change ----------------------------- As men grow older, their testosterone levels drop a little more than one percent each year after the age of 40. This typically results in a condition now dubbed andropause – also called male menopause – which manifests with moodiness, memory loss, a gradual decline in sex drive, and a lack of energy, strength and endurance. Other less obvious problems are the decrease of lean muscle mass and bone mineral density in the spine. Taken together, these conditions often conspire to create a gradual passivity and disinterest in life. The question is: Should andropause be accepted as a normal part of aging, or should it be regarded as a medical condition that requires treatment? Ultimately, that question can only be answered individually by each man experiencing it. For those who choose to address the problem, there are several avenues available, including specific exercise regimens, a variety of natural supplements that help your body raise its own testosterone levels, or testosterone replacement therapies. In the opinion of Unimed, however, testosterone replacement therapy is the only way to go. There are other pharmaceutical companies out there that offer TRT in the form of pills, patches and muscle injections, but Unimed's AndroGel – approved by the FDA two years ago – is the fastest growing and most aggressively marketed TRT. ----------------------------- Who's your daddy? ----------------------------- Testosterone is the big daddy of the androgens – male sex hormones responsible for the development of sperm and sex characteristics in general. AndroGel takes its name from androgen, of course – that and the fact that it's a gel that users rub on their shoulders once each day. A month's supply isn't cheap, running about $250 dollars, and a trip to the doctor is required because it's a prescription drug. But not all physicians will prescribe AndroGel. Apparently there are still some doctors out there who are unconvinced that andropause should be treated by replacing testosterone. That's why Unimed has aimed its andropause " awareness " campaign at both doctors and patients alike. But some very special marketing strategies have been devised for the medical side of the campaign. ----------------------------- Buying results ----------------------------- In April 2000, the Endocrine Society held its First Annual Andropause Consensus Conference. Their goal: define andropause and assess the need for treatment. A panel of 13 respected endocrinologists concluded that andropause is a genuine health concern and that all men over the age of 50 should be screened for a deficiency of testosterone. In setting the bar for when a man should be prescribed treatment, they decided on the parameters for a " normal " range of testosterone levels in blood samples, even though their one-size-fits-all normal range matched the typical range for men in their twenties. The panel stopped short at recommending specific treatments, but for anyone prepared to mount an " awareness " campaign, the official acknowledgement of andropause as a condition suffered by millions in need of medical treatment was as good as gold. And who provided the grant that was the only source of funding for the conference? Unimed. That fact was well known. What was not reported until recently, however, was that 9 of the 13 conference panelists (including the chair and co-chair) had financial ties to Unimed by the usual means that pharmaceutical companies " employ " medical professionals: through grants for research and fees paid for consulting assignments and speaking engagements. ----------------------------- Not so fast ----------------------------- For those who choose to treat andropause with pharmaceuticals, the cumulative effects of TRT are largely unknown because no long-term studies have been conducted. So until we understand how users react to the drug over a period of several years, there's no way that TRT can be regarded as safe. This is especially so in light of the fact that known TRT side effects include testicular shrinkage, abnormal enlargement of the breasts and an elevation in circulating blood cell level which can lead to stroke and heart failure. Forty years ago, pharmaceutical companies were telling women that estrogen was the answer to menopausal problems such as sexual health and moodiness. At the time there were no long term studies to rely on for information, so the marketing ran far ahead of safety. Through the years many women have paid a dear price for trusting hormone replacement therapy. In 2043, will we be saying the same about men who put their faith in an expensive gel? ----------------------------- Another angle ----------------------------- ....and another thing Protecting cells from the DNA damage that can trigger disease and promote the aging process was the subject of a recent e-Alert ( " Sir2, With Love " 4/8/03), in which I told you how nicotinamide helps cells build a protective barrier. Several members sent e-mails with questions about a supplement recommendation and the nicotinamide/niacin connection. Here's one from a member named Patti: " In Jenny's alert today, she talked about nicotinamide AND niacin, the first being a derivative of the second. However, I'm confused about the recommendation for the purposes delineated in the article...is she suggesting nicotinamide OR niacin? The xxx Naturals product noted at the end of the article is apparently niacin. " And Shirley wrote with a more specific question about how to find the supplement I mentioned: " I have visited the xxxx.com website, and nicotinamide is nowhere to be found, nor is Coenzymated B3 listed on Source Naturals website. Is the spelling correct? Or should I be looking for something else? " Nicotinamide is a derivative of niacin (also known as vitamin B3) and a precursor to a coenzyme called nicotinamide adenine dinucleotide (NAD), which your body requires to activate the cell protective effects of a protein called Sir2p. To put it more simply: for our purposes we can think of nicotinamide and niacin as being one and the same. The xxx Naturals product Coenzymated B3 is " niacin as NAD. " And when you go looking for it on the xxxx Naturals web site there are two important things to remember: 1) xxxx Naturals is a wholesaler, so you can't order any of their products directly through the site. They certainly don't make it easy to find, but considering the benefits of this supplement, I believe the search will be worth the little extra trouble. Happy hunting! To Your Good Health, Jenny Thompson Health Sciences Institute ************************************************************** Sources: " Hormones for Men " The New Yorker, 7/29/02 " Male hormone gel may pose risks " NBC News, 7/31/02 " Andropause, the Male Menopause " Monterey Preventive Medical Clinic Copyright ©1997-2003 by www.hsibaltimore.com, L.L.C. 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