Yale researchers who cooked up a deadlier strainof the human form of mad cow disease (wake up!)

March 16, 2004

GENTECH archive 8.96-97

[index][Thread] Science Magazine Study on CJD Variations

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Science Magazine Study on CJD Variations

Purefood

Sat, 5 Jul 1997 08:57:44 -0400 (EDT)

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>Headline: UPI Science News>Wire Service: UPn (UPI US & World)>Thu, Jul 3,

following news report may not be republished or redistributed, in wholeor>in

part, without the prior written consent of United Press International.>>

WASHINGTON, July 3 (UPI) -- Yale researchers who cooked up a deadlierstrain>of

the human form of mad cow disease say public health officials may be>overlooking

important signs of the infection.> In an experiment described today in the

journal Science, Dr. Laura>Manuelidis, a professor and head of neuropathology at

Yale Medical School,>found>that when she infected a series of mice, hamsters and

rats with>Creutzfeldt-Jakob disease (CJD) -- the human form of mad cow disease

-- shesaw>different physical responses as it was passed from one set of animals

to the>next.> In addition to becoming more deadly, the disease caused

reactions not>commonly thought to be part of CJD infection.>

Some of the rats had early brain inflammation, for example, before

more>common signs of CJD -- such as the development of brain plaques and

the>accumulation of mutant forms of proteins called prions -- started to

showup.> Prions set off chain reactions that damage other proteins, which

destroy>brain tissue.> She says " when I saw inflammatory cells, I went nuts. I

knew the host was>responding in a very different way, " from what researchers

expected.> Manuelidis says that the variation in response in the rats shows

that the>infectious agents that cause CJD are " not set in stone, " but can

" changeand>evolve and cause variable disease. " > Since 1985, about a million

cows may have become infected with mad cow>disease, also known as bovine

spongiform encephalopathy or BSE, by eatingsheep>meat and bone meal contaminated

by scrapie, the form of the disease that>strikes>sheep. There have also been

reports of domestic cats and zoo animals>coming down>with the disease.> Since

then,

scientists believe some humans picked up a new form CJD by>eating>meat from

sick cattle.> The CDC says that there have been no cases of the new form of

CJD>detected so>far in the United States.> But public health officials,

Manuelidis says, may be missing manyinfected>individuals because their view of

the disease is too narrow, focusing on the>development of brain plaques and the

accumulation of CJD prions and ignoring>other signs, such as inflammation. They

are also not taking into accountCJD's>quick change capabilities.> " They are

clearly not realizing that these strains are variable, " says>Manuelidis, who was

among the first group of scientists to show that humanCJD>could be transmitted

karl theis jr

http://groups.msn.com/exposureofthetruth

madcowcoverup-

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March 16, 2004

---

If you are interested in checking out the Gentech archive index and

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karl

In , MadcowCoverup <k_t723>

wrote:

> GENTECH archive 8.96-97

>

> [index][Thread] Science Magazine Study on CJD Variations

>

> gentech@t...

> Science Magazine Study on CJD Variations

> Purefood@a...

> Sat, 5 Jul 1997 08:57:44 -0400 (EDT)

> Resent-gentech@t...

> Resent-Message-ID: <ag0km.A._uC.jAovz

> Resent-Sender: gentech-request@t...

>

> >Headline: UPI Science News>Wire Service: UPn (UPI US & World)

republished or redistributed, in wholeor>in part, without the prior

written consent of United Press International.>> WASHINGTON, July

3 (UPI) -- Yale researchers who cooked up a deadlierstrain>of the

human form of mad cow disease say public health officials may

be>overlooking important signs of the infection.> In an experiment

described today in the journal Science, Dr. Laura>Manuelidis, a

professor and head of neuropathology at Yale Medical

School,>found>that when she infected a series of mice, hamsters and

rats with>Creutzfeldt-Jakob disease (CJD) -- the human form of mad

cow disease -- shesaw>different physical responses as it was passed

from one set of animals to the>next.> In addition to becoming more

deadly, the disease caused reactions not>commonly thought to be part

of CJD infection.>

> Some of the rats had early brain inflammation, for example,

before more>common signs of CJD -- such as the development of brain

plaques and the>accumulation of mutant forms of proteins called

prions -- started to showup.> Prions set off chain reactions that

damage other proteins, which destroy>brain tissue.> She says " when

I saw inflammatory cells, I went nuts. I knew the host

was>responding in a very different way, " from what researchers

expected.> Manuelidis says that the variation in response in the

rats shows that the>infectious agents that cause CJD are " not set in

stone, " but can " changeand>evolve and cause variable disease. " >

Since 1985, about a million cows may have become infected with mad

cow>disease, also known as bovine spongiform encephalopathy or BSE,

by eatingsheep>meat and bone meal contaminated by scrapie, the form

of the disease that>strikes>sheep. There have also been reports of

domestic cats and zoo animals>coming down>with the disease.> Since

then,

> scientists believe some humans picked up a new form CJD

by>eating>meat from sick cattle.> The CDC says that there have

been no cases of the new form of CJD>detected so>far in the United

States.> But public health officials, Manuelidis says, may be

missing manyinfected>individuals because their view of the disease

is too narrow, focusing on the>development of brain plaques and the

accumulation of CJD prions and ignoring>other signs, such as

inflammation. They are also not taking into accountCJD's>quick

change capabilities.> " They are clearly not realizing that these

strains are variable, " says>Manuelidis, who was among the first

group of scientists to show that humanCJD>could be transmitted to

>

> karl theis jr

>

> http://groups.msn.com/exposureofthetruth

>

> madcowcoverup-

>

> theoneswithoutnames-

>

> Mail - More reliable, more storage, less spam

>

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