Guest guest Posted October 23, 2006 Report Share Posted October 23, 2006 Impact of BCG vaccination on tuberculin surveys to estimate the annual risk of tuberculosis infection in south India P.G. Gopi, R. Subramani, T. Nataraj & P.R. Narayanan Tuberculosis Research Centre, (ICMR), Chennai, India Received October 14, 2005 Background & objectives: Annual risk of tuberculosis infection (ARTI) computed from prevalence of infection measures the extent of tuberculosis transmission in the community and it is used to monitor the tuberculosis control programme. This is usually derived from tuberculin surveys among children not vaccinated with BCG. This study explores whether the estimated ARTI among BCG vaccinated children is comparable to that of unvaccinated children. Methods: Three tuberculin surveys were undertaken among children aged <10 yr as part of assessing the impact of DOTS implemented in Tiruvallur district, south India. The prevalence of infection was estimated using the anti-mode method among vaccinated and unvaccinated children. The ARTI was computed separately and compared in all the three surveys. Results: The prevalence of infection among unvaccinated and vaccinated children in the first survey were 7.8 per cent (95% CI: 7.1-8.6) and 7.9 per cent (95% CI: 7.1-8.8) respectively (ARTI was estimated to be 1.6 per cent in both groups) and the difference was not statistically significant. The corresponding figures for children test read in the second and third surveys were 6.9 per cent (95% CI: 6.2-7.6) and 6.8 per cent (6.0-7.5) and; 6.0 per cent (5.2-6.7) and 6.0 per cent (5.5-6.5) respectively. The computed ARTI was respectively 1.4 and 1.2 per cent among unvaccinated children in the second and third surveys; and 1.4 and 1.2 per cent among vaccinated children in the second and third rounds. Interpretation & conclusion: There was no difference in the infection with Mycobacterium tuberculosis among vaccinated and unvaccinated children. BCG vaccinated children may thus be included for estimation of infection to assess the extent of transmission in the community as well as for monitoring purpose. Link to pdf file available here. http://www.icmr.nic.in/ijmr/2006/july/contents.htm After all, they (the pro-vaccine lobbyists) say to themselves, you can't make an omelette withoutbreaking eggs. But the eggs being broken are small, helpless, and innocent babies, while the omelette is being enjoyed by the pediatricians and vaccine manufacturers. - Harris L. Coulter, PhD Get your email and more, right on the new .com Quote Link to comment Share on other sites More sharing options...
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