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Apparently there is a an eye medication, Xalacom™, that can cause the iris

to change color:

 

*Latanoprost may gradually change the eye colour by increasing the amount of

brown pigment in the iris. This effect has predominantly been seen in

patients with mixed colour irides, i.e. green-brown, yellow-brown or

blue/grey/brown, and is due to the increased melanin content in the stromal

melanocytes in the iris. Typically the brown pigmentation around the pupil

spreads concentrically towards the periphery in the affected eyes, but the

entire iris or parts of it may become more brownish.

The change in iris colour occurs slowly and may not be noticeable for

several months to years, and it has not been associated with any symptom or

pathological changes.

No further increase in brown pigment has been observed after discontinuation

of treatment, but the resultant colour change may be permanent.

(emphasis mine)*

**

AND that last part is interesting. So, genetics can't obviously be the only

factor.

http://www.intekom.com/pharm/pharmaca/xalacom.html

 

 

 

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