Situation Analysis: Heterogeneous Bioreactors: The Single Body Problem

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Situation Analysis: Heterogeneous

Bioreactors: The Single Body Problem

 

 

Heterogeneous bioreactors in operation usually

are by design, and results from the introduction of the carriers on

which is implemented the immobilization of the microbes performing the

bio-reaction. This form of by-design heterogeneity, however, is

distinctly different from the heterogeneity that characterizes scale up

issues. The heterogeneity due to scale up is mostly characterized by

variations in the reaction mixture environment, and is addressed

through fluid dynamic analysis of the bioreactor at time of

development. The heterogeneous character obtaining from the

introduction of carriers, however, effectively creates a Random

Newtonian Many Body Problem out of each such bioreactor. In effect, the

computational design of heterogeneous bioreactors transforms into the

computational analysis of a variant of Random Media Analysis, which, of

course, can always be reduced to a Newtonian Single Body Problem.

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