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BBC Bird flu's 'huge potential risk'

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>BBC DAILY E-MAIL: UK EDITION

>Thursday, 22 April, 2004, 8:00 GMT 01:00 -07:00:US/Pacific

>

> * Bird flu's 'huge potential risk' *

>Avian influenza could be a massive threat to

>people if it continues to evolve, a British

>scientist says.

>Full story:

>http://news.bbc.co.uk/go/em/-/1/hi/sci/tech/3643643.stm

>

>

..

Bird flu's 'huge potential risk'

By Alex Kirby

BBC News Online environment correspondent

Bird flu could develop into a threat big enough

to overturn world order if it evolves to transfer

directly from person to person, a UK scientist

says.

 

Dr John McCauley, of the Institute for Animal

Health, said the virus could be 20 times worse

than the 1918 pandemic.

 

That is estimated to have killed 40 million

people, with later influenza outbreaks also

killing millions more.

 

Dr McCauley said there was a realistic chance of

the current avian flu virus evolving to threaten

people directly.

 

Dr McCauley, whose research into avian influenza

is being funded by the Biotechnology and

Biological Sciences Research Council (BBSRC), was

speaking to BBC News Online.

 

Practical possibility

 

He said: " At the moment the virus affects humans

only after transferring to them from poultry. In

1997 six people died in Hong Kong after 18 became

infected. This year, 23 patients have died from a

total of about 34 people infected in south-east

Asia.

 

" That means there is a mortality rate from some

strains of highly pathogenic avian infuenza of

between 30 and 60% of those infected. In 1918,

the rate was about 1%.

 

" There's no reason to say the virus will not

continue to evolve so that it can transmit

directly from one person to another. There's a

realistic chance that could happen.

 

" If it does - if the virus becomes adapted to man

and can transmit efficiently - there'll be no

point in selling a vaccine. You might as well

give it away at that stage, because money would

be meaningless. The world order would change. "

 

Dr McCauley said the global flu epidemics of 1957

and 1968 had involved a mixing of avian and human

forms of the virus, and it looked as if that had

happened in 1918 as well.

 

So people killing infected birds should be taking

anti-flu drugs to guard against the possibility

of being infected with both forms and creating a

pandemic.

 

Dr McCauley said: " Any complacency could lead to

devastation for the UK poultry industry. I think

the avian form of the disease has not been

cleared up in any of the affected countries. "

 

Seeking answers

 

In poultry the effects of bird flu can range from

a mild touch of disease to a highly fatal and

rapidly spreading epidemic.

 

Teams from the Institute for Animal Health and

the universities of Cambridge and Oxford are

cooperating to unravel the dynamics of bird flu.

 

Cambridge scientists, with the Roslin Institute,

are working to produce a breed of chicken that is

genetically resistant to infection by the virus,

engineering the bird's cells to produce small

molecules of RNA that can selectively prevent its

replication.

 

The BBSRC is to fund 14 new research projects

costing £11m ($19.5m) under its Combating Viral

Diseases of Livestock Initiative.

 

 

Story from BBC NEWS:

http://news.bbc.co.uk/go/pr/fr/-/1/hi/sci/tech/3643643.stm

 

Published: 2004/04/21 14:06:48 GMT

 

© BBC MMIV

 

--

 

 

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