Severe hypoglycaemia from non-prescription erection-booster drugs

[Guest guest]

I found this on a more consumer oriented web-site....

Doug

 

http://biolife.wordpress.com/2008/02/15/walnut-sex-wonder-pill-kills/

_______

 

In the absence of the Viagra/Cialis alternative, N-Hanz that the Malaysian

researchers have reported to have developed last year using walnuts, the only

available walnut-based anti-erectile dysfunction solutions should be those from

China, one of which was exhibited in last year's Canton Fair.

 

 

 

 

 

Yesterday, the Singapore Health Sciences Authority (HSA) has issued a warning

against a product called `Power 1 Walnut'. The name of the product must have

misled ignorant sexually dysfunctional people into thinking that it contains

natural herbal ingredients, not knowing that this `Power 1 Walnut' contains 2

potent ingredients, glibenclamide and sildenafil which can be deadly if

mishandled. These 2 are strict prescription medicines – glibenclamide is used

for treating diabetes and sildenafil is the drug found in Viagra which treats

impotency.

 

HSA founded that this `wonder` pill is more like a diabetes drug than a sexual

enhancement one as it contains 90mg of glibenclamide – about 5 times the amount

prescribed to a diabetic patient – and only 7mg of sildenafil, far below the

25mg to 100mg needed for any sexual enhancement effect.

 

 

`Power 1 Walnut', supposedly manufactured by a company in Guangzhou, China is

one of the 36,000 illegal sexual enhancement pills seized by police and HSA 2

evenings ago.

 

At the time of the report by ChannelNews Asia, 6 male people who had consumed

`Power 1 Walnut' suffered a serious adverse reaction, resulting in hypoglycaemia

(very low blood sugar levels) and if untreated in time, could lead to

unconsciousness, seizures and sometimes death. Although the 6 patients were

discovered and treated, one of them is critically ill and is under close

observation in a hospital.

 

 

 

 

, " " < wrote:

>

> Hi All, especially elderly males!

>

> This abstract describes an outbreak of severe hypoglycaemia in HK

> males who used non-prescription erection-boosting drugs - sildenafil

> products containing glibenclamide.

>

> Note: Sildenafil and glibenclamide belong to different drug groups

> with different indications and have never been used in the same

> formulation. Here we present the first cluster of hypoglycaemia cases

> after taking non-prescription products containing both sildenafil and

> glibenclamide. The recommended therapeutic dosages of glibenclamide

> and sildenafil are 2.5-15 mg daily and 25-100 mg daily, respectively.

> Quantitative analysis of the 25 unused capsules/tablets revealed a

> glibenclamide content of 70 (0-158) mg per product. ONE such

> capsule/tablet can cause intractable hypoglycaemia and lead to

> permanent neurological damage or death. In some of the products, the

> sildenafil content was subtherapeutic (many were <10 mg). Individuals

> might take more than one capsule or tablet to obtain the desired

> effect, thus dramatically increasing the extent of overdosing. The

> full text is at http://www.hkmj.org/article_pdfs/hkm0906p196.pdf

>

> Poon WT, Lam YH, Lee HC, Ching CK, Chan WT, Chan SS, Lai CK, Tse ML,

> Chan YW, Mak WL. Outbreak of hypoglycaemia: sexual enhancement

> products containing oral hypoglycaemic agent. Hong Kong Med J

> 2009;15:196-200. Hospital Authority Toxicology Reference Laboratory,

> Princess Margaret Hospital, Laichikok, HK. Objectives: To describe a

> cluster of HK subjects with hypoglycaemia, after they had taken

> various non-prescription sildenafil products containing

> glibenclamide. Design: Retrospective study. Setting: A tertiary

> referral centre for clinical toxicology analysis in Hong Kong.

> Patients: All men referred to the laboratory for investigation of

> suspected drug-induced hypoglycaemia from December 2007 to September

> 2008. Main outcome measures: The characteristics of these patients,

> including their clinical presentations, outcomes, drug history, urine

> toxicology analysis results, and in some instances, analysis results

> of unused products. Results: A total of 144 males were referred for

> suspected drug-induced hypoglycaemia. Sildenafil and glibenclamide,

> or their metabolites, were detected in the urine specimens of 68

> (47%) patients, none of whom had been prescribed either drug by a

> registered medical practitioner. Among these subjects, 24 (35%)

> denied any use of sexual enhancement products despite repeated

> questioning. 8 patients had repeated exposure resulting in re-

> admission. The sources of these sexual enhancement products included

> pharmacies in Mainland China, friends, local pharmacies, peddlers, or

> were unknown. Three patients died, one remains in a vegetative state

> and one suffered cognitive impairment; the remaining 63 recovered

> fully. 25 unused sexual enhancement products of 7 different kinds

> were recovered for analysis. The median (range) of sildenafil and

> glibenclamide per unit dose was 64 (0.05-198) mg and 70 (0-158) mg,

> respectively. Conclusion: These illegal products pose a severe and

> continued threat to society and therefore deserve widespread

> vigilance, so that such products can be eradicated at their source.

>

> Best regards,

>

>

[Guest guest]

Hi All, especially elderly males!

 

This abstract describes an outbreak of severe hypoglycaemia in HK

males who used non-prescription erection-boosting drugs - sildenafil

products containing glibenclamide.

 

Note: Sildenafil and glibenclamide belong to different drug groups

with different indications and have never been used in the same

formulation. Here we present the first cluster of hypoglycaemia cases

after taking non-prescription products containing both sildenafil and

glibenclamide. The recommended therapeutic dosages of glibenclamide

and sildenafil are 2.5-15 mg daily and 25-100 mg daily, respectively.

Quantitative analysis of the 25 unused capsules/tablets revealed a

glibenclamide content of 70 (0-158) mg per product. ONE such

capsule/tablet can cause intractable hypoglycaemia and lead to

permanent neurological damage or death. In some of the products, the

sildenafil content was subtherapeutic (many were <10 mg). Individuals

might take more than one capsule or tablet to obtain the desired

effect, thus dramatically increasing the extent of overdosing. The

full text is at http://www.hkmj.org/article_pdfs/hkm0906p196.pdf

 

Poon WT, Lam YH, Lee HC, Ching CK, Chan WT, Chan SS, Lai CK, Tse ML,

Chan YW, Mak WL. Outbreak of hypoglycaemia: sexual enhancement

products containing oral hypoglycaemic agent. Hong Kong Med J

2009;15:196-200. Hospital Authority Toxicology Reference Laboratory,

Princess Margaret Hospital, Laichikok, HK. Objectives: To describe a

cluster of HK subjects with hypoglycaemia, after they had taken

various non-prescription sildenafil products containing

glibenclamide. Design: Retrospective study. Setting: A tertiary

referral centre for clinical toxicology analysis in Hong Kong.

Patients: All men referred to the laboratory for investigation of

suspected drug-induced hypoglycaemia from December 2007 to September

2008. Main outcome measures: The characteristics of these patients,

including their clinical presentations, outcomes, drug history, urine

toxicology analysis results, and in some instances, analysis results

of unused products. Results: A total of 144 males were referred for

suspected drug-induced hypoglycaemia. Sildenafil and glibenclamide,

or their metabolites, were detected in the urine specimens of 68

(47%) patients, none of whom had been prescribed either drug by a

registered medical practitioner. Among these subjects, 24 (35%)

denied any use of sexual enhancement products despite repeated

questioning. 8 patients had repeated exposure resulting in re-

admission. The sources of these sexual enhancement products included

pharmacies in Mainland China, friends, local pharmacies, peddlers, or

were unknown. Three patients died, one remains in a vegetative state

and one suffered cognitive impairment; the remaining 63 recovered

fully. 25 unused sexual enhancement products of 7 different kinds

were recovered for analysis. The median (range) of sildenafil and

glibenclamide per unit dose was 64 (0.05-198) mg and 70 (0-158) mg,

respectively. Conclusion: These illegal products pose a severe and

continued threat to society and therefore deserve widespread

vigilance, so that such products can be eradicated at their source.

 

Best regards,