Vaccination and autoimmune disease- Part one

[Guest guest]

I am a PhD Immunologist with a special interest in Nutritional Genomics. I

also have 3 immune mediated diseases, MS, Diabetes M. - and a skin disorder.

There those that MS is not a true autoimmune disorder but is really a breakdown

in the immune response in that the anti antibodies are not functioning

correctly. With respect to autoimmune response and the use of vaccinations one

must first consider the MHC.The MHC is an area of the genome whose function is

to help the immune system recognize " self " from non-self and it is the name

of the human major histocompatibility complex. This group of genes resides on

chromosome 6, and encodes cell-surface antigen-presenting proteins. It does

not code for an antigen or antibody but codes for the receptor sites on the

surface of a subset of T-cells whose job it is, is to present antigen to B-cells

in order for them to make antibodies against that particular antigen.

 

The receptor site is able to fit the antigen because of specific

stereochemical properties with regard to the shape of the molecule- bond length

and

angle between the various atoms that make up the molecule. The reason we need

diversity of the antigen presenting proteins is that our bodies need to be able

to recognize a variety of different pathogenic antigens. Without this

diversity our immune system would not be able to present the antigen and we

would

therefore not be able to make antibodies against it...to be continued

Susan

 

 

 

 

 

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[Guest guest]

Hi Doctor Susan,

 

It sounds like you are suggesting that scientists who develop vaccines should

look at MHC proteins and be sure that the antigenic determinants of their

vaccines have broad diversity from the MHC proteins of the target population.

Is this your suggestion? Perhaps we have the technology for accomplishing this

now. Do you think?

 

Respectfully and gratefully,

Emmanuel Segmen

------------------------

Docvite wrote:

>

> I am a PhD Immunologist with a special interest in Nutritional Genomics. I

> also have 3 immune mediated diseases, MS, Diabetes M. - and a skin disorder.

> There those that MS is not a true autoimmune disorder but is really a

breakdown

> in the immune response in that the anti antibodies are not functioning

> correctly. With respect to autoimmune response and the use of vaccinations one

> must first consider the MHC.The MHC is an area of the genome whose function is

> to help the immune system recognize " self " from non-self and it is the name

> of the human major histocompatibility complex. This group of genes resides on

> chromosome 6, and encodes cell-surface antigen-presenting proteins. It does

> not code for an antigen or antibody but codes for the receptor sites on the

> surface of a subset of T-cells whose job it is, is to present antigen to

B-cells

> in order for them to make antibodies against that particular antigen.

>

> The receptor site is able to fit the antigen because of specific

> stereochemical properties with regard to the shape of the molecule- bond

length and

> angle between the various atoms that make up the molecule. The reason we need

> diversity of the antigen presenting proteins is that our bodies need to be

able

> to recognize a variety of different pathogenic antigens. Without this

> diversity our immune system would not be able to present the antigen and we

would

> therefore not be able to make antibodies against it...to be continued

> Susan

>

>