Green Tea and Arizona Cactus Pear Reduce Cervical Cancer

[Guest guest]

I thought this was an interesting study. Has anyone used the cactus

pear? I'm curious if Agave would have similar properties?

Tymothy

 

 

Jean M. Feugang, Francisco Garcia, Chaofeng Sun, Jian Wang, Andrew

Abalos, Sui Zhang and Changping Zou

University of Arizona, Dept of OB/GYN, Tucson, AZ, MD Anderson Cancer

Center, Dept of Cardiovascular, Houston, TX, Arizona Cancer Ctr.,

University of Arizona, Tucson, AZ

 

Cervical cancer is the third most common gynecologic malignancy in

the world, accounting for 15% of all cancers diagnosed in women.

Cervical cancer has a well-characterized pre-malignant phase,

cervical intraepithelial neoplasia (CIN). CIN is detectable using

readily available well-established techniques including exfoliative

cervical cytology (Pap smear), human papillomavirus (HPV) testing,

and colposcopy. These facts make cervical cancer/CIN an ideal target

for chemoprevention. Cancer chemoprevention is the administration of

chemical agents to prevent or delay the development of cancer, in

which chemical agents are used to prevent cancer in normal and/or

high-risk populations. However, the number of currently available

preventive agents is limited and the chemical agents are costly.

Natural products, such as certain herbs have demonstrated anti-cancer

effects. We investigated Arizona cactus extracts and green tea

compounds (EGCG and polyphenol E) for their anti-cancer effects in

cultured immortalized cervical epithelial cells and cervical cancer

cells. Green tea compound and aqueous extracts of cactus pear were

used to treat immortalized cervical epithelial cells and cervical

cancer cells. The cactus mix and green tea compounds were used at six

concentrations 0, 0.5, 1, 5, 10 or 25% and 0, 1, 5, 10, 25, 50 µg/ml,

respectively. Growth inhibition, apoptosis induction, and cell cycle

were analyzed in these cells. Cells exposed to these two natural

products had a significant increase in apoptosis, especially cactus

mix and tea-EGCG. Tea-poly E had a little effect on apoptosis

induction at concentration of 50 µg/ml; however it increased G1 and

decreased S phases. Natural products effectively inhibited

immortalized cervical epithelial cells and cervical cancer cells

growth, and induced apoptosis. The mechanism of the anti-cancer

effects of natural products needs to be elucidated in future studies.

Supported by the Women's Fund for Health, Education and Research, and

the National Institutes of Health, National Cancer Institute

(NIH/NCI), grant number NOI-CN-35158.

[Guest guest]

Hello all,

Would this cactus be the same as Prickly Pear Cactus or Nopal,

which I believe is grown in the high mountains / desert of Mexico..

I eat them as vegetable.

Google Nopal for more info.

It's been known to the natives as antiCancer.

amy

 

 

 

 

************************************** See what's new at http://www.aol.com

 

 

 

[Guest guest]

Interesting. a HPV+ patient just had a loop excision this week of abnl

cells. she's looking for prevention measures. i wonder were one might find

green tea or cactus pear compound, or is this something the patient can

concoct?

 

kath

 

 

On 10/12/07, miracles28 <jellyphish wrote:

>

> I thought this was an interesting study. Has anyone used the cactus

> pear? I'm curious if Agave would have similar properties?

> Tymothy

>

> Jean M. Feugang, Francisco Garcia, Chaofeng Sun, Jian Wang, Andrew

> Abalos, Sui Zhang and Changping Zou

> University of Arizona, Dept of OB/GYN, Tucson, AZ, MD Anderson Cancer

> Center, Dept of Cardiovascular, Houston, TX, Arizona Cancer Ctr.,

> University of Arizona, Tucson, AZ

>

> Cervical cancer is the third most common gynecologic malignancy in

> the world, accounting for 15% of all cancers diagnosed in women.

> Cervical cancer has a well-characterized pre-malignant phase,

> cervical intraepithelial neoplasia (CIN). CIN is detectable using

> readily available well-established techniques including exfoliative

> cervical cytology (Pap smear), human papillomavirus (HPV) testing,

> and colposcopy. These facts make cervical cancer/CIN an ideal target

> for chemoprevention. Cancer chemoprevention is the administration of

> chemical agents to prevent or delay the development of cancer, in

> which chemical agents are used to prevent cancer in normal and/or

> high-risk populations. However, the number of currently available

> preventive agents is limited and the chemical agents are costly.

> Natural products, such as certain herbs have demonstrated anti-cancer

> effects. We investigated Arizona cactus extracts and green tea

> compounds (EGCG and polyphenol E) for their anti-cancer effects in

> cultured immortalized cervical epithelial cells and cervical cancer

> cells. Green tea compound and aqueous extracts of cactus pear were

> used to treat immortalized cervical epithelial cells and cervical

> cancer cells. The cactus mix and green tea compounds were used at six

> concentrations 0, 0.5, 1, 5, 10 or 25% and 0, 1, 5, 10, 25, 50 µg/ml,

> respectively. Growth inhibition, apoptosis induction, and cell cycle

> were analyzed in these cells. Cells exposed to these two natural

> products had a significant increase in apoptosis, especially cactus

> mix and tea-EGCG. Tea-poly E had a little effect on apoptosis

> induction at concentration of 50 µg/ml; however it increased G1 and

> decreased S phases. Natural products effectively inhibited

> immortalized cervical epithelial cells and cervical cancer cells

> growth, and induced apoptosis. The mechanism of the anti-cancer

> effects of natural products needs to be elucidated in future studies.

> Supported by the Women's Fund for Health, Education and Research, and

> the National Institutes of Health, National Cancer Institute

> (NIH/NCI), grant number NOI-CN-35158.

>

>

>

 

 

 

--

Kath Bartlett, LAc, MS, BA UCLA

Oriental Medicine

Experienced, Dedicated, Effective

 

Asheville Center For

70 Woodfin Place, Suite West Wing Two

Asheville, NC 28801 828.258.2777

kbartlett

www.AcupunctureAsheville.com

 

 

 

[Guest guest]

Thanks for that response Andrea Beth.

I only know that kind bought at the store, called Nopal.

There was a mixture of Nopal, Flax seeds, citrus peel, ect. (can't remember

the others)

made in Canada eaten as a b'fast cereal. I tried one bag, then not

available anymore.

It's noted anti-oxidant/anti-Cancer on the label. I took it to regulate BMs.

Take care.

amy

 

 

 

************************************** See what's new at http://www.aol.com

 

 

 

[Guest guest]

Actually, there are many varieties of prickly pear cactus that are native to

Arizona. I wonder which one they tested?

 

 

 

Amyc144 wrote: Hello all,

Would this cactus be the same as Prickly Pear Cactus or Nopal,

which I believe is grown in the high mountains / desert of Mexico..

I eat them as vegetable.

Google Nopal for more info.

It's been known to the natives as antiCancer.

amy

 

 

 

 

************************************** See what's new at http://www.aol.com

 

 

 

[Guest guest]

I recently had a drink I purchased with prickly pear cactus, a lemonade

purchased at Whole Foods.I wonder if the drink could not also be made with green

tea and sold like that.If the sugars were kept out, would make a nice

tea.Sincerely,Patricia Jordan DVM,CVA,CTCVM & Herbology

 

 

:

jellyphish: Fri, 12 Oct 2007 14:50:03 +0000Green

Tea and Arizona Cactus Pear Reduce Cervical Cancer

 

 

 

 

I thought this was an interesting study. Has anyone used the cactuspear? I'm

curious if Agave would have similar properties?TymothyJean M. Feugang, Francisco

Garcia, Chaofeng Sun, Jian Wang, AndrewAbalos, Sui Zhang and Changping

ZouUniversity of Arizona, Dept of OB/GYN, Tucson, AZ, MD Anderson CancerCenter,

Dept of Cardiovascular, Houston, TX, Arizona Cancer Ctr.,University of Arizona,

Tucson, AZCervical cancer is the third most common gynecologic malignancy inthe

world, accounting for 15% of all cancers diagnosed in women.Cervical cancer has

a well-characterized pre-malignant phase,cervical intraepithelial neoplasia

(CIN). CIN is detectable usingreadily available well-established techniques

including exfoliativecervical cytology (Pap smear), human papillomavirus (HPV)

testing,and colposcopy. These facts make cervical cancer/CIN an ideal targetfor

chemoprevention. Cancer chemoprevention is the administration ofchemical agents

to prevent or delay the development of cancer, inwhich chemical agents are used

to prevent cancer in normal and/orhigh-risk populations. However, the number of

currently availablepreventive agents is limited and the chemical agents are

costly.Natural products, such as certain herbs have demonstrated

anti-cancereffects. We investigated Arizona cactus extracts and green

teacompounds (EGCG and polyphenol E) for their anti-cancer effects incultured

immortalized cervical epithelial cells and cervical cancercells. Green tea

compound and aqueous extracts of cactus pear wereused to treat immortalized

cervical epithelial cells and cervicalcancer cells. The cactus mix and green tea

compounds were used at sixconcentrations 0, 0.5, 1, 5, 10 or 25% and 0, 1, 5,

10, 25, 50 µg/ml,respectively. Growth inhibition, apoptosis induction, and cell

cyclewere analyzed in these cells. Cells exposed to these two naturalproducts

had a significant increase in apoptosis, especially cactusmix and tea-EGCG.

Tea-poly E had a little effect on apoptosisinduction at concentration of 50

µg/ml; however it increased G1 anddecreased S phases. Natural products

effectively inhibitedimmortalized cervical epithelial cells and cervical cancer

cellsgrowth, and induced apoptosis. The mechanism of the anti-cancereffects of

natural products needs to be elucidated in future studies.Supported by the

Women's Fund for Health, Education and Research, andthe National Institutes of

Health, National Cancer Institute(NIH/NCI), grant number NOI-CN-35158.

 

 

 

 

 

 

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