Medline Herbal Abstracts

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Alzheimer's disease (AD) treatment

and its derivative ZT-1

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anyone knows what zt-1 is

 

 

 

 

 

510-452-503

 

 

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vBMA

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traditional_Chinese_Medicine

Sunday, July 29, 2007 9:01 PM

Medline Herbal Abstracts

 

 

Hi All,

 

See:

 

Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232-5.Links [Comparision of

different interventional therapies for primary liver cancer] [Article in

Chinese]

Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and

Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong

University, Xi'an 710061, China. doctor-lym OBJECTIVE: To

investigate the efficacy of different interventional therapies for primary

hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after

hepatectomy were treated by different kinds of interventional therapies:

transcatheter arterial chemoembolization (TACE), TACE and radio-

frequency ablation (RFA), Chinese traditional medicine and biotherapy after

TACE or the transcatheter arterial infusion (TAI). The results of liver

function, alpha-fetoprotein, imaging, color-ultrasonography and survival rate

were reviewed. RESULTS: 874 patients were followed up for 2 to 63

months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and

18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received

TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after

hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate (

PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was

74.5% and 36.8%, respectively, after TACE and RFA. The response rate

(PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%,

21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI

was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child

grade of liver function, color-ultrasonography and alpha-fetoprotein of TACE

+ RFA group, TACE and TAI were compared. There was no significant

difference between each above mentioned index among TACE, RFA or

TACE groups. CONCLUSION: Compared with other modalities,

transcatheter arterial chemoembolization (TACE) before or after

hepatectomy is more effective than other interventional therapies for primary

hepatocellular cancer, whereas, if combined with radiofrequency ablation

(TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed

- in process]

 

Prog Brain Res. 2007;162:525-46. Links Oxidative stress and ischemic

injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of

Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of

Injury Prevention and Control, Taipei Medical University and Municipal Wan-

Fan Hospital, Taipei, Taiwan. When rats were exposed to high

environmental temperature (e.g., 42 or 43 degrees C), hyperthermia,

hypotension, and cerebral ischemia and damage occurred during heat

stroke were associated with increased production of free radicals

(specifically hydroxyl radicals and superoxide anions), higher lipid

peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic

pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with

conventional hydroxyl radical scavengers (e.g., mannitol or alpha-

tocopherol) prevented increased production of hydroxyl radicals, increased

levels of lipid peroxidation, and ischemic neuronal damage in different brain

structures attenuated with heat stroke and increased subsequent survival

time. Heat shock preconditioning (a mild sublethal heat exposure for 15min)

or regular, daily exercise for at least 3 weeks, in addition to inducing

overproduction of heat shock protein 72 in multiple organs including brain,

significantly attenuated the heat stroke-induced hyperthermia, hypotension,

cerebral ischemia and damage, and overproduction of hydroxyl radicals and

lipid peroxidation. The precise function of heat shock protein 72 are

unknown, but there is considerable evidence that these proteins are

essential for survival at both normal and elevated temperatures. They also

play a critical role in the development of thermotolerance and protection

from oxidative damage associated with cerebral ischemia and energy

depletion during heat stroke. In addition, Shengmai San or magnolol

(Chinese herbal medicines) or hypervolemic hemodilution (produced by

intravenous infusion of 10% human albumin) is effective for prevention and

repair of ischemic and oxidative damage in the brain during heat stroke.

Thus, it appears that heat shock protein 72 preconditioning induced by prior

heat shock or regular exercise training, as well as pretreatment with

Shengmai San or magnolol is able to prevent the oxidative damage during

heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San,

or magnolol is able to treat the oxidative damage after heat stroke onset.

PMID: 17645935 [PubMed - in process]

 

J Ethnopharmacol. 2007 Aug 15;113(1):15-34. Epub 2007 Jun 2. Links

Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X,

Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research,

Institute of Materia Medica, Shanghai Institutes for Biological Sciences,

Chinese Academy of Sciences, Shanghai 201203, PR China; Department of

Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes

Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated

originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of

Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae

family, has attracted intense attention since its marked anticholinesterase

activity was discovered by Chinese scientists. Several members of the

Huperziaceae (Huperzia and Phlegmariurus species) have been used as

medicines in China for contusions, strains, swellings, schizophrenia,

myasthenia gravis and organophosphate poisoning. HupA has been

marketed in China as a new drug for Alzheimer's disease (AD) treatment

and its derivative ZT-1 is being developed as anti-AD new drug candidate

both in China and in Europe. A review of the chemistry, bioactivities,

toxicology, clinical trials and natural resources of HupA source plants is

presented. PMID: 17644292 [PubMed - as supplied by publisher]

 

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[Guest guest]

Hi All,

 

Mello VJ, Gomes MT, Lemos FO, Delfino JL, Andrade SP, Lopes MT, Salas

CE. The gastric ulcer protective and healing role of cysteine proteinases

from Carica candamarcensis. Phytomedicine. 2007 Aug 7; [Epub ahead of

print] Dept de Farmacologia, ICB, Universidade Federal Minas Gerais, Belo

Horizonte, CEP 31270-901, Brazil. Latex from Caricaceae contains

proteolytic enzymes localized in the fruit, which are used

ethnopharmacologically to treat digestive disorders. Some of these proteins

display proliferative properties when probed with mammalian cells,

suggesting a role in the reconstruction of wounded tissue. We tested the

efficacy of a proteolytic fraction derived from Carica candamarcensis,

designated as P1G10 in experimental rodent models, to protect and heal

chemically induced gastric ulcers. The protective effect of oral administration

of P1G10 fraction was analyzed in indomethacin-treated Wistar animals.

The healing effect of P1G10 was studied following sub-serous injection of

acetic acid in a Wistar rat model. The results show that P1G10 between 0.1

and 10mg/kg protect indomethacin but not ethanol-induced gastric ulcers.

The maximal protection attained was 67% with 10mg/kg of P1G10. The

healing rate by 10mg/kg of P1G10 using the acetic acid ulcerogenic model is

similar to that of omeprazole (10mg/kg) or ranitidine (100mg/kg). The effect

of P1G10 at 10mg/kg seems to be mediated by an increase in the mucus

content by 25% and stimulation of angiogenesis by 64% in a manner similar

to growth factors. These results confirm the protective and healing role of

proteinases from C. candamarcensis. PMID: 17689943 [PubMed - as

supplied by publisher]

 

Banz WJ, Iqbal MJ, Bollaert M, Chickris N, James B, Higginbotham DA,

Peterson R, Murphy L. Ginseng modifies the diabetic phenotype and genes

associated with diabetes in the male ZDF rat. Phytomedicine. 2007 Aug 7;

[Epub ahead of print] Dept of Animal Science, Food and Nutrition, Southern

Illinois University, Carbondale, IL 62901-4317, USA; Department of

Physiology, Southern Illinois University, Carbondale, IL 62901, USA. Asian

ginseng (Panax ginseng) and its close relative North American ginseng

(Panax quinquefolius) are perennial aromatic herbs that are widely used in

Oriental medicine and have been acclaimed to have various health benefits

including diabetes treatment. In this study, we compared the effects of a diet

containing rosiglitazone to a diet containing ginseng (Panax quinquefolius) in

male Zucker diabetic fatty (ZDF) rats. Animals were assigned to one of three

diets: control, rosiglitazone (0.1g/1kg diet), or ginseng (10g/1kg diet). During

the 11-week study, body weight, food intake, organ weight, blood glucose,

plasma cholesterol, and plasma triglyceride levels were evaluated. Animals

treated with rosiglitazone or ginseng exhibited increased body weight

(p<0.05) and decreased kidney weight (p<0.05) compared to control

animals. The rosiglitazone group demonstrated decreased food intake and

plasma triglyceride levels versus the other groups (p<0.05). The ginseng

group revealed decreased cholesterol levels relative to the control group

(p<0.05). Furthermore, ginseng and rosiglitazone had marked effects on the

expression of genes involved in PPAR actions and triglyceride metabolism

compared to controls. In conclusion, ginseng modified the diabetic

phenotype and genes associated with diabetes in the male ZDF rat. These

data are encouraging, and warrant further research to determine the

therapeutic value of this medicinal herb in treating human diabetes. PMID:

17689944 [PubMed - as supplied by publisher]

 

Kwee SH, Tan HH, Marsman A, Wauters C. The effect of Chinese herbal

medicines (CHM) on menopausal symptoms compared to hormone

replacement therapy (HRT) and placebo. Maturitas. 2007 Sep 20;58(1):83-

90. Epub 2007 Aug 8. Private Clinics, Amsterdam & The Hague, The

Netherlands. OBJECTIVE: To evaluate within the Traditional Chinese

Medicine (TCM) setting, the effect of CHM-formulae on menopausal

symptoms. DESIGN: A double-blind and double-dummy randomised

placebo-controlled trial. METHOD: Between February and June 2002 and

June and October 2004, 31 peri- and postmenopausal Dutch women were

recruited to complete 12 weeks of treatment with either CHM formulae

(n=10), HRT (n=11) or placebo (n=10) medications plus 4 weeks of non-

treatment follow-up observation. Hereby a double-dummy setting is applied,

i.e. the medications and placebo's taken were both capsules and liquid

extracts. Appropriate to the TCM setting, the CHM-prescriptions could be

adjusted according to the symptoms and signs of the individuals for that

moment. MAIN OUTCOME MEASURES: The primary end-point was the

reduction in frequency of vasomotor symptoms (hot flushes and night

sweats). Secondary end-point were the improvements measured in quality

of life questionnaire SF-36 and other symptoms and signs related to the

peri- and postmenopausal period. RESULTS: Placebo had a score of 30%.

Compared to Placebo, on average CHM is 29% significantly (p<0.05) more

effective in reducing the amount of hot flushes, while HRT is almost 50%.

Although quantitatively there was a significant difference in the reduction of

hot flushes between groups, qualitatively there was no overall improvement.

CONCLUSIONS: This pilot study proved clearly that CHM could help women

with their menopausal problems. The chosen trial methodology with its TCM

differential diagnosis after orthodox medicine diagnosis is fully compatible

with TCM practice and hence acceptable for western and Chinese medical

practitioners. For a place in the western health care system, we need to

conduct a larger trial with a more menopause specific questionnaire. PMID:

17689896 [PubMed - in process]

 

Olagbende-Dada SO, Ezeobika EN, Duru FI. Anabolic effect of Hibiscus

rosasinensis Linn. leaf extracts in immature albino male rats. Nig Q J Hosp

Med. 2007 Jan-Mar;17(1):5-7. Department of Pharmacognosy, Faculty of

Pharmacy, College of Medicine, University of Lagos, Idi-Araba, Lagos,

Nigeria. Many plants remedies have been employed in solving man's health

needs especially the nutritive value which enhances health living.

Aphrodisiac plants are plants with anabolic properties i.e. they help in protein

synthesis and enhances sexual abilities in males. They are also known as

androgenic plants because their properties are similar to that of androgen a

male hormone. Cold aqueous extract of Hibiscus rosasinensis leaves is

reported by local traditional practioners in Western Nigeria to be aphrodisiac.

OBJECTIVE: To investigate the anabolic properties of Hibiscus

rosasinensis. MATERIALS AND METHOD: Three groups (8/group) of

immature male rats of known weights were administered equal doses of

aqueous (cold and hot) and alcoholic extracts of Hibiscus rosasinensis

leaves for 8 weeks. The gain in body and isolated sexual organs (testis,

epididymis, seminal vesicle and prostate) weights were determined after

treatment and compared to the value obtained from a fourth untreated group

which served as the control. Section through the testes of both the treated

and untreated rats were also examined microscopically and displayed as a

photomicrograph for comparism. All data were statistically analysed and

displaced in graphic form. RESULTS: Over the 8 weeks of treatment, the

control, the cold aqueous extract dosed, hot aqueous extract dosed and

alcoholic extract dosed rats gained 8%, 15%, 18% and 22% in body weights

respectively. The increase in the weight of testis, epididymis, seminal vesicle

and prostate of the alcoholic extract dosed rats was 19%, 30%, 31% and

40% respectively. CONCLUSION: The anabolic effect of the leaf extracts of

H. rosasinensis is hereby established. More work needs to be done on these

leaf extracts to know their effect on the gonadotrophin hormones which

regulate the activity of the androgens in relation to spermatogenesis. PMID:

17688164 [PubMed - indexed for MEDLINE]

 

Best regards,