Guest guest Posted August 22, 2007 Report Share Posted August 22, 2007 Dear Rebekka & other Colleagues, For those of you that like to imagine that the anatomic spleen (like the CM Spleen) is more than just a dispensable organ, you are now in good company with Western science. See this paper below for yet another entry into the Paradigm Bridge Chronicles. Dr. Denise Faustman should be quite an inspiration to any aspiring woman scientist. She certainly is an inspiration to Dr. Shohta Kodama, MD PhD who works in Faustman's lab at Harvard. I thought you'd like this, Rebekka. Respectfully, Emmanuel Segmen Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med 2005 Jun;11(6):271-6 (ISSN: 1471-4914) Kodama S; Davis M; Faustman DL Harvard Medical School & Massachusetts General Hospital-East Immunology Lab, Building 149, 13(th) Street, Room 3602, Boston, MA 02193, USA. The spleen has long been considered a dispensable organ. Recent research, however, has found that the spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages. Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis. The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros. By bringing together findings from diverse disciplines, we propose that the adult spleen is an important source of multi-lineage stem cells for future cellular therapies for diabetes and other diseases. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 22, 2007 Report Share Posted August 22, 2007 Thank you for the reference, Emmanuel. The article can be read online here: http://www.massgeneral.org/diabetes/articles/TMM.pdf Early in my studies Bruno Braeckman introduced me the book of Matsumoto & Birch " Hara diagnosis: reflections on the sea " . Starting from page 131 there is an elaborate description of Chinese medical anatomy and what Emmanual calles 'paradigm bridges'. There is a particularly interesting passage relating to embryology and the development of the du mai, ren mai and chong mai, which Bruno summarized as follows: The chong mai is being related to the notocord/ mesoderm. It gives rise to the blood and blood vessels ( " the Sea of blood " ); and the fasciae and the connective tissues, from which the triple burner and the vessels and collaterals ( " the Sea of the 12 vessels " ) and the zang fu ( " the Sea of the 5 viscera and 6 bowels " ) develop. Embryologically it is true that the organs stem from the mesenchym. The du mai is related to the neural tube/ ectoderm. The epidermis (skin) and the nervous system (spinal cord and brain) stem from it, which are also the yang areas of the body (the Sea of yang). The ren mai is related to the digestive system/ endoderm; from which the endothelium of almost all organs and the endocrine system develop (the Sea of yin). What is also remarkable is that the traditional transition areas between the ren and du mai (as practised in the Taoist microcosmic orbit) are also overlappings between the endoderm and ectoderm: - in the palate: digestive endothelium ->brain tissue - in the perineum: large intestine + urogenital endothelium ->epidermis Perhaps we can even relate adenohypofysis (endodermal and ectodermal origin) to ren mai and neurohypofysis (ectodermal orgin) to du mai. What do you think of this? Regards, Tom. ---- Emmanuel Segmen 22/08/2007 1:38:33 Chinese Medicine Paradigm Bridges Dear Rebekka & other Colleagues, For those of you that like to imagine that the anatomic spleen (like the CM Spleen) is more than just a dispensable organ, you are now in good company with Western science. See this paper below for yet another entry into the Paradigm Bridge Chronicles. Dr. Denise Faustman should be quite an inspiration to any aspiring woman scientist. She certainly is an inspiration to Dr. Shohta Kodama, MD PhD who works in Faustman's lab at Harvard. I thought you'd like this, Rebekka. Respectfully, Emmanuel Segmen Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med 2005 Jun;11(6):271-6 (ISSN: 1471-4914) Kodama S; Davis M; Faustman DL Harvard Medical School & Massachusetts General Hospital-East Immunology Lab, Building 149, 13(th) Street, Room 3602, Boston, MA 02193, USA. The spleen has long been considered a dispensable organ. Recent research, however, has found that the spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages. Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis. The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros. By bringing together findings from diverse disciplines, we propose that the adult spleen is an important source of multi-lineage stem cells for future cellular therapies for diabetes and other diseases. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 22, 2007 Report Share Posted August 22, 2007 Early in my studies Bruno Braeckman introduced me the book of Matsumoto & Birch " Hara diagnosis: reflections on the sea " . Starting from page 131 there is an elaborate description of Chinese medical anatomy and what Emmanual calles 'paradigm bridges'. For details of this book, see http://www.chinesemedicinetimes.com/product/286/222/hara_diagnosis__reflecti ons_on_the_sea Attilio Quote Link to comment Share on other sites More sharing options...
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