Guest guest Posted July 30, 2007 Report Share Posted July 30, 2007 Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232-5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonography and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonography and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525-46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15-34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0); VOIP Number: +353-1482-7068; Tel: (M): +353-(0) " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 30, 2007 Report Share Posted July 30, 2007 Alzheimer's disease (AD) treatment and its derivative ZT-1 <<<<<<< anyone knows what zt-1 is 510-452-503 - vBMA Cc: ; traditional_Chinese_Medicine Sunday, July 29, 2007 9:01 PM Medline Herbal Abstracts Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232-5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonography and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonography and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525-46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15-34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0); VOIP Number: +353-1482-7068; Tel: (M): +353-(0) " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2007 Report Share Posted July 31, 2007 Hey Alon. ZT-1 is a supa-secret codename for Huperzine A, which is itself but an alias for the alkaloid extracted from the Chinese Club Moss, which is often named, in turn, " Shuan Yi Ping " (among others). This alkaloid is said to be as effective with a smaller side-effect profile than the best western isolate, Donepezil. But who knows; it is but mere moss!! Hugo Alon Marcus <alonmarcus ; vBMA Cc: ; traditional_Chinese_Medicine Sunday, 29 July, 2007 9:12:16 PM Re: Medline Herbal Abstracts Alzheimer's disease (AD) treatment and its derivative ZT-1 <<<<<<< anyone knows what zt-1 is 510-452-503 www.integrativeheal thmedicine. com - vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, July 29, 2007 9:01 PM Medline Herbal Abstracts Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232- 5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym (AT) 163 (DOT) com OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonograp hy and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonograp hy and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525- 46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15- 34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0)1-6281- 222; VOIP Number: +353-1482-7068; Tel: (M): +353-(0)87-286- 8277 http://homepage. eircom.net/ ~progers/ vaplinks. htm http://homepage. eircom.net/ ~progers/ tecnotes. htm " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2007 Report Share Posted July 31, 2007 I have been using Huperizine for many years now. Its hard to know but it may be of some help Alon Hugo Ramiro <subincor wrote: Hey Alon. ZT-1 is a supa-secret codename for Huperzine A, which is itself but an alias for the alkaloid extracted from the Chinese Club Moss, which is often named, in turn, " Shuan Yi Ping " (among others). This alkaloid is said to be as effective with a smaller side-effect profile than the best western isolate, Donepezil. But who knows; it is but mere moss!! Hugo Alon Marcus <alonmarcus ; vBMA Cc: ; traditional_Chinese_Medicine Sunday, 29 July, 2007 9:12:16 PM Re: Medline Herbal Abstracts Alzheimer's disease (AD) treatment and its derivative ZT-1 <<<<<<< anyone knows what zt-1 is 510-452-503 www.integrativeheal thmedicine. com - vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, July 29, 2007 9:01 PM Medline Herbal Abstracts Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232- 5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym (AT) 163 (DOT) com OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonograp hy and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonograp hy and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525- 46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15- 34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0)1-6281- 222; VOIP Number: +353-1482-7068; Tel: (M): +353-(0)87-286- 8277 http://homepage. eircom.net/ ~progers/ vaplinks. htm http://homepage. eircom.net/ ~progers/ tecnotes. htm " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2007 Report Share Posted August 1, 2007 Hi Alon...who have you been using it on? Hugo Alon Marcus <alonmarcus Chinese Medicine Tuesday, 31 July, 2007 3:03:33 PM Re: Re: Medline Herbal Abstracts I have been using Huperizine for many years now. Its hard to know but it may be of some help Alon Hugo Ramiro <subincor > wrote: Hey Alon. ZT-1 is a supa-secret codename for Huperzine A, which is itself but an alias for the alkaloid extracted from the Chinese Club Moss, which is often named, in turn, " Shuan Yi Ping " (among others). This alkaloid is said to be as effective with a smaller side-effect profile than the best western isolate, Donepezil. But who knows; it is but mere moss!! Hugo Alon Marcus <alonmarcus (AT) wans (DOT) net> ; vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, 29 July, 2007 9:12:16 PM Re: Medline Herbal Abstracts Alzheimer's disease (AD) treatment and its derivative ZT-1 <<<<<<< anyone knows what zt-1 is 510-452-503 www.integrativeheal thmedicine. com - vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, July 29, 2007 9:01 PM Medline Herbal Abstracts Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232- 5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym (AT) 163 (DOT) com OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonograp hy and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonograp hy and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525- 46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15- 34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0)1-6281- 222; VOIP Number: +353-1482-7068; Tel: (M): +353-(0)87-286- 8277 http://homepage. eircom.net/ ~progers/ vaplinks. htm http://homepage. eircom.net/ ~progers/ tecnotes. htm " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2007 Report Share Posted August 1, 2007 begging Alzheimer's - Hugo Ramiro Chinese Medicine Wednesday, August 01, 2007 6:17 AM Re: Re: Medline Herbal Abstracts Hi Alon...who have you been using it on? Hugo Alon Marcus <alonmarcus Chinese Medicine Tuesday, 31 July, 2007 3:03:33 PM Re: Re: Medline Herbal Abstracts I have been using Huperizine for many years now. Its hard to know but it may be of some help Alon Hugo Ramiro <subincor > wrote: Hey Alon. ZT-1 is a supa-secret codename for Huperzine A, which is itself but an alias for the alkaloid extracted from the Chinese Club Moss, which is often named, in turn, " Shuan Yi Ping " (among others). This alkaloid is said to be as effective with a smaller side-effect profile than the best western isolate, Donepezil. But who knows; it is but mere moss!! Hugo Alon Marcus <alonmarcus (AT) wans (DOT) net> ; vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, 29 July, 2007 9:12:16 PM Re: Medline Herbal Abstracts Alzheimer's disease (AD) treatment and its derivative ZT-1 <<<<<<< anyone knows what zt-1 is 510-452-503 www.integrativeheal thmedicine. com - vBMA (AT) MILEPOST1 (DOT) COM Cc: ; traditional_ Chinese_Medicine Sunday, July 29, 2007 9:01 PM Medline Herbal Abstracts Hi All, See: Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232- 5.Links [Comparision of different interventional therapies for primary liver cancer] [Article in Chinese] Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China. doctor-lym (AT) 163 (DOT) com OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after hepatectomy were treated by different kinds of interventional therapies: transcatheter arterial chemoembolization (TACE), TACE and radio- frequency ablation (RFA), Chinese traditional medicine and biotherapy after TACE or the transcatheter arterial infusion (TAI). The results of liver function, alpha-fetoprotein, imaging, color-ultrasonograp hy and survival rate were reviewed. RESULTS: 874 patients were followed up for 2 to 63 months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and 18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate ( PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was 74.5% and 36.8%, respectively, after TACE and RFA. The response rate (PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%, 21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child grade of liver function, color-ultrasonograp hy and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared. There was no significant difference between each above mentioned index among TACE, RFA or TACE groups. CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed - in process] Prog Brain Res. 2007;162:525- 46. Links Oxidative stress and ischemic injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University and Municipal Wan- Fan Hospital, Taipei, Taiwan. When rats were exposed to high environmental temperature (e.g., 42 or 43 degrees C), hyperthermia, hypotension, and cerebral ischemia and damage occurred during heat stroke were associated with increased production of free radicals (specifically hydroxyl radicals and superoxide anions), higher lipid peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with conventional hydroxyl radical scavengers (e.g., mannitol or alpha- tocopherol) prevented increased production of hydroxyl radicals, increased levels of lipid peroxidation, and ischemic neuronal damage in different brain structures attenuated with heat stroke and increased subsequent survival time. Heat shock preconditioning (a mild sublethal heat exposure for 15min) or regular, daily exercise for at least 3 weeks, in addition to inducing overproduction of heat shock protein 72 in multiple organs including brain, significantly attenuated the heat stroke-induced hyperthermia, hypotension, cerebral ischemia and damage, and overproduction of hydroxyl radicals and lipid peroxidation. The precise function of heat shock protein 72 are unknown, but there is considerable evidence that these proteins are essential for survival at both normal and elevated temperatures. They also play a critical role in the development of thermotolerance and protection from oxidative damage associated with cerebral ischemia and energy depletion during heat stroke. In addition, Shengmai San or magnolol (Chinese herbal medicines) or hypervolemic hemodilution (produced by intravenous infusion of 10% human albumin) is effective for prevention and repair of ischemic and oxidative damage in the brain during heat stroke. Thus, it appears that heat shock protein 72 preconditioning induced by prior heat shock or regular exercise training, as well as pretreatment with Shengmai San or magnolol is able to prevent the oxidative damage during heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San, or magnolol is able to treat the oxidative damage after heat stroke onset. PMID: 17645935 [PubMed - in process] J Ethnopharmacol. 2007 Aug 15;113(1):15- 34. Epub 2007 Jun 2. Links Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X, Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China; Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. PMID: 17644292 [PubMed - as supplied by publisher] Best regards, 1 Esker Lawns, Lucan, Dublin, Ireland Tel: (H): +353-(0)1-6281- 222; VOIP Number: +353-1482-7068; Tel: (M): +353-(0)87-286- 8277 http://homepage. eircom.net/ ~progers/ vaplinks. htm http://homepage. eircom.net/ ~progers/ tecnotes. htm " Man who says it can't be done should not interrupt woman doing it " - Chinese Proverb Quote Link to comment Share on other sites More sharing options...
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