Cognition A B Vitamin Deficiency

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Cognition A B Vitamin Deficiency

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Summary# 46831 Topic: B Vitamin Deficiency Leads to Hyperhomocysteinemia and Cognitive Impairment Summary: In a study involving male mice, being fed a diet deficient in vitamin B for 10 weeks was found to induce hyperhomocysteinemia and significantly impair spatial learning and memory. In addition, a significant rarefaction of hippocampal microvasculature without concomitant gliosis and neurodegeneration was found. The authors conclude, "Our findings suggest that cerebral microvascular rarefaction can cause cognitive dysfunction in the absence of or preceding neurodegeneration. Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline."

Keywords: COGNITIVE IMPAIRMENT, HYPERHOMOCYSTEINEMIA, AGING - Vitamin B Deficiency, Homocysteine Reference: "B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice," Troen AM, Shea-Budgell M, et al, Proc Natl Acad Sci USA, 2008; 105(34): 12474-9. (Address: Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111-1524, USA. E-mail: aron.tr... (AT) tufts (DOT) edu ). ------------------------------

"Increased tHcy levels are associated with cognitive impairment"

http://www.ncbi.nlm.nih.gov/pubmed/18080853

Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J Neurol. 2008 Jan;255(1):64-9. Epub 2007 Dec 20. Links Russo C, Morabito F, Luise F, Piromalli A, Battaglia L, Vinci A, Trapani Lombardo V, de Marco V, Morabito P, Condino F, Quattrone A, Aguglia U. Neurologic Unit, Azienda Ospedaliera, Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.

Hyperhomocysteinemia (HHcy) has been associated with cognitive impairment in various neurological diseases. Cognitive impairment occurs early in multiple sclerosis (MS). Conflicting data have been reported regarding plasma total homocysteine (tHcy) levels in MS patients, and the impact of HHcy on cognitive impairment in MS is not known. This study investigated whether plasma total homocysteine levels are increased in MS and if HHcy is associated with cognitive impairment in MS.

We conclude that tHcy levels are increased in MS and that HHcy is associated with cognitive impairment in this disease.

PMID: 18080853