Guest guest Posted August 25, 2008 Report Share Posted August 25, 2008 http://www.nationalpost.com/news/story.html?id=a042812e-492c-4f07-8245-8a598ab5d1bf & k=63970 Diabetes breakthrough Toronto scientists cure disease in mice Tom Blackwell, National Post Published: Friday, December 15, 2006 In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians. Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas. "I couldn't believe it," said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. "Mice with diabetes suddenly didn't have diabetes any more." The researchers caution they have yet to confirm their findings in people, but say they expect results from human studies within a year or so. Any treatment that may emerge to help at least some patients would likely be years away from hitting the market. But the excitement of the team from Sick Kids, whose work is being published today in the journal Cell, is almost palpable. "I've never seen anything like it," said Dr. Hans Michael Dosch, an immunologist at the hospital and a leader of the studies. "In my career, this is unique." Their conclusions upset conventional wisdom that Type 1 diabetes, the most serious form of the illness that typically first appears in childhood, was solely caused by auto-immune responses -- the body's immune system turning on itself. They also conclude that there are far more similarities than previously thought between Type 1 and Type 2 diabetes, and that nerves likely play a role in other chronic inflammatory conditions, such as asthma and Crohn's disease. The "paradigm-changing" study opens "a novel, exciting door to address one of the diseases with large societal impact," said Dr. Christian Stohler, a leading U.S. pain specialist and dean of dentistry at the University of Maryland, who has reviewed the work. "The treatment and diagnosis of neuropathic diseases is poised to take a dramatic leap forward because of the impressive research." About two million Canadians suffer from diabetes, 10% of them with Type 1, contributing to 41,000 deaths a year. Insulin replacement therapy is the only treatment of Type 1, and cannot prevent many of the side effects, from heart attacks to kidney failure. In Type 1 diabetes, the pancreas does not produce enough insulin to shift glucose into the cells that need it. In Type 2 diabetes, the insulin that is produced is not used effectively -- something called insulin resistance -- also resulting in poor absorption of glucose. The problems stem partly from inflammation -- and eventual death -- of insulin-producing islet cells in the pancreas. Dr. Dosch had concluded in a 1999 paper that there were surprising similarities between diabetes and multiple sclerosis, a central nervous system disease. His interest was also piqued by the presence around the insulin-producing islets of an "enormous" number of nerves, pain neurons primarily used to signal the brain that tissue has been damaged. Suspecting a link between the nerves and diabetes, he and Dr. Salter used an old experimental trick -- injecting capsaicin, the active ingredient in hot chili peppers, to kill the pancreatic sensory nerves in mice that had an equivalent of Type 1 diabetes. "Then we had the biggest shock of our lives," Dr. Dosch said. Almost immediately, the islets began producing insulin normally "It was a shock ? really out of left field, because nothing in the literature was saying anything about this." It turns out the nerves secrete neuropeptides that are instrumental in the proper functioning of the islets. Further study by the team, which also involved the University of Calgary and the Jackson Laboratory in Maine, found that the nerves in diabetic mice were releasing too little of the neuropeptides, resulting in a "vicious cycle" of stress on the islets. So next they injected the neuropeptide "substance P" in the pancreases of diabetic mice, a demanding task given the tiny size of the rodent organs. The results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection. They also discovered that their treatments curbed the insulin resistance that is the hallmark of Type 2 diabetes, and that insulin resistance is a major factor in Type 1 diabetes, suggesting the two illnesses are quite similar. While pain scientists have been receptive to the research, immunologists have voiced skepticism at the idea of the nervous system playing such a major role in the disease. Editors of Cell put the Toronto researchers through vigorous review to prove the validity of their conclusions, though an editorial in the publication gives a positive review of the work. "It will no doubt cause a great deal of consternation," said Dr. Salter about his paper. The researchers are now setting out to confirm that the connection between sensory nerves and diabetes holds true in humans. If it does, they will see if their treatments have the same effects on people as they did on mice. Nothing is for sure, but "there is a great deal of promise," Dr. Salter said. 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Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible-to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...??? All of the people I know with diabetes seem to be the very careful, do-what-the-doctor-says types. I wish I could find someone who would be willing to try this application... Any takers on board?? With blessings, Molly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 I don't have diabetes but you might have something there Molly. It might be cheaper just to use MSM instead of the DMSO. MSM will carry it through the skin also. You can also mix a powdered aspirin with MSM and it will carry it through to reach pain and the aspirin will not get into your stomach where it causes problems. I believe MSM is the one of the main ingredients of DMSO. - Molly G Wednesday, September 03, 2008 9:22 AM Re:Diabetes breakthrough!!! M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible-to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...???All of the people I know with diabetes seem to be the very careful, do-what-the-doctor-says types. I wish I could find someone who would be willing to try this application... Any takers on board??With blessings,Molly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 MSM contains two methyl groups attached to a sulfur. DMSO has this also, but with an added oxygen that gives it the extra penetrating ability. Ultimately, they both work very well. If you check the safety levels for MSM they are the same as those for pure water so there is little chance for negative effects or interactions with other foods and drugs. If you want to try MSM you really need to use 10 grams per day to see results quickly. This means a minimum of eight caps per day. You can reduce the cost by half if you use the powder, but it has a taste that is intolerable to some. You can mask the taste by mixing it in organic or homemade apple sauce and water and slugging it down quickly followed by water to wash the mouth.--- On Wed, 9/3/08, Harvey Flatbush <harvf wrote: Harvey Flatbush <harvfRe: Re:Diabetes breakthrough!!! Date: Wednesday, September 3, 2008, 1:12 PM I don't have diabetes but you might have something there Molly. It might be cheaper just to use MSM instead of the DMSO. MSM will carry it through the skin also. You can also mix a powdered aspirin with MSM and it will carry it through to reach pain and the aspirin will not get into your stomach where it causes problems. I believe MSM is the one of the main ingredients of DMSO. - Molly G Wednesday, September 03, 2008 9:22 AM [Health_and_ Healing] Re:Diabetes breakthrough! !! M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible- to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...???All of the people I know with diabetes seem to be the very careful, do-what-the- doctor-says types. I wish I could find someone who would be willing to try this application. .. Any takers on board??With blessings,Molly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 You would just need to try a small spot first as Cayenne is an irritant (used as a counter irritant in shingles) and could irritate/burn abdo skin which doesn't get as much wear and tear like arms and legs Yes, I'd be happy to try this on my husband - thats a good idea to try it this way. Jane - Molly G I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible-to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...??? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2008 Report Share Posted September 4, 2008 Jane, I'm so excited to see if it will work! I hope your husband won't mind being the guinea pig... If I had diabetes, I would have already tried it and had the report online, but that's just me...always leapin' before lookin'... Let us know if you have any positive...or negative...results, Jane. I'll be waiting on pins and needles. Blessings to you, Molly , " Jane MacRoss " <highfield1 wrote: > > You would just need to try a small spot first as Cayenne is an irritant (used as a counter irritant in shingles) and could irritate/burn abdo skin which doesn't get as much wear and tear like arms and legs > > Yes, I'd be happy to try this on my husband - thats a good idea to try it this way. > > Jane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2008 Report Share Posted September 4, 2008 since i don't 'do what the doctors says, " i will be happy to try the dmso/cayenne on the pancreas area. instructions please. diana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2008 Report Share Posted September 4, 2008 I have been capping my own MSM for about six years now. but only take two a day when I take my vitamins. http://www.cap-m-quik.com/index.html - Tony De Angelis Wednesday, September 03, 2008 1:08 PM Re: Re:Diabetes breakthrough!!! MSM contains two methyl groups attached to a sulfur. DMSO has this also, but with an added oxygen that gives it the extra penetrating ability. Ultimately, they both work very well. If you check the safety levels for MSM they are the same as those for pure water so there is little chance for negative effects or interactions with other foods and drugs. If you want to try MSM you really need to use 10 grams per day to see results quickly. This means a minimum of eight caps per day. You can reduce the cost by half if you use the powder, but it has a taste that is intolerable to some. You can mask the taste by mixing it in organic or homemade apple sauce and water and slugging it down quickly followed by water to wash the mouth.--- On Wed, 9/3/08, Harvey Flatbush <harvf (AT) iomet (DOT) com> wrote: Harvey Flatbush <harvf (AT) iomet (DOT) com>Re: Re:Diabetes breakthrough!!! Date: Wednesday, September 3, 2008, 1:12 PM I don't have diabetes but you might have something there Molly. It might be cheaper just to use MSM instead of the DMSO. MSM will carry it through the skin also. You can also mix a powdered aspirin with MSM and it will carry it through to reach pain and the aspirin will not get into your stomach where it causes problems. I believe MSM is the one of the main ingredients of DMSO. - Molly G Wednesday, September 03, 2008 9:22 AM [Health_and_ Healing] Re:Diabetes breakthrough! !! M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible- to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...???All of the people I know with diabetes seem to be the very careful, do-what-the- doctor-says types. I wish I could find someone who would be willing to try this application. .. Any takers on board??With blessings,Molly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2008 Report Share Posted September 4, 2008 Two caps per day will only maintain the ststus quo.--- On Thu, 9/4/08, Harvey Flatbush <harvf wrote: Harvey Flatbush <harvfRe: Re:Diabetes breakthrough!!! Date: Thursday, September 4, 2008, 12:39 PM I have been capping my own MSM for about six years now. but only take two a day when I take my vitamins. http://www.cap- m-quik.com/ index.html - Tony De Angelis Wednesday, September 03, 2008 1:08 PM Re: [Health_and_ Healing] Re:Diabetes breakthrough! !! MSM contains two methyl groups attached to a sulfur. DMSO has this also, but with an added oxygen that gives it the extra penetrating ability. Ultimately, they both work very well. If you check the safety levels for MSM they are the same as those for pure water so there is little chance for negative effects or interactions with other foods and drugs. If you want to try MSM you really need to use 10 grams per day to see results quickly. This means a minimum of eight caps per day. You can reduce the cost by half if you use the powder, but it has a taste that is intolerable to some. You can mask the taste by mixing it in organic or homemade apple sauce and water and slugging it down quickly followed by water to wash the mouth.--- On Wed, 9/3/08, Harvey Flatbush <harvf (AT) iomet (DOT) com> wrote: Harvey Flatbush <harvf (AT) iomet (DOT) com>Re: [Health_and_ Healing] Re:Diabetes breakthrough! !!Wednesday, September 3, 2008, 1:12 PM I don't have diabetes but you might have something there Molly. It might be cheaper just to use MSM instead of the DMSO. MSM will carry it through the skin also. You can also mix a powdered aspirin with MSM and it will carry it through to reach pain and the aspirin will not get into your stomach where it causes problems. I believe MSM is the one of the main ingredients of DMSO. - Molly G Wednesday, September 03, 2008 9:22 AM [Health_and_ Healing] Re:Diabetes breakthrough! !! M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible- to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...???All of the people I know with diabetes seem to be the very careful, do-what-the- doctor-says types. I wish I could find someone who would be willing to try this application. .. Any takers on board??With blessings,Molly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2008 Report Share Posted September 4, 2008 OOPs. the word is "status" quo -sorry for typo --- On Thu, 9/4/08, Tony De Angelis <tntstuart wrote: Tony De Angelis <tntstuartRe: Re:Diabetes breakthrough!!! Date: Thursday, September 4, 2008, 4:00 PM Two caps per day will only maintain the ststus quo.--- On Thu, 9/4/08, Harvey Flatbush <harvf (AT) iomet (DOT) com> wrote: Harvey Flatbush <harvf (AT) iomet (DOT) com>Re: [Health_and_ Healing] Re:Diabetes breakthrough! !!Thursday, September 4, 2008, 12:39 PM I have been capping my own MSM for about six years now. but only take two a day when I take my vitamins. http://www.cap- m-quik.com/ index.html - Tony De Angelis Wednesday, September 03, 2008 1:08 PM Re: [Health_and_ Healing] Re:Diabetes breakthrough! !! MSM contains two methyl groups attached to a sulfur. DMSO has this also, but with an added oxygen that gives it the extra penetrating ability. Ultimately, they both work very well. If you check the safety levels for MSM they are the same as those for pure water so there is little chance for negative effects or interactions with other foods and drugs. If you want to try MSM you really need to use 10 grams per day to see results quickly. This means a minimum of eight caps per day. You can reduce the cost by half if you use the powder, but it has a taste that is intolerable to some. You can mask the taste by mixing it in organic or homemade apple sauce and water and slugging it down quickly followed by water to wash the mouth.--- On Wed, 9/3/08, Harvey Flatbush <harvf (AT) iomet (DOT) com> wrote: Harvey Flatbush <harvf (AT) iomet (DOT) com>Re: [Health_and_ Healing] Re:Diabetes breakthrough! !!Wednesday, September 3, 2008, 1:12 PM I don't have diabetes but you might have something there Molly. It might be cheaper just to use MSM instead of the DMSO. MSM will carry it through the skin also. You can also mix a powdered aspirin with MSM and it will carry it through to reach pain and the aspirin will not get into your stomach where it causes problems. I believe MSM is the one of the main ingredients of DMSO. - Molly G Wednesday, September 03, 2008 9:22 AM [Health_and_ Healing] Re:Diabetes breakthrough! !! M.M., thanks for posting this article! I am certain this will be the last any of us hear about the research, as it will probably be shut down, or at least hidden, by the Canadian government and Big Pharma. I was thinking of a way to deliver the cayenne directly to the pancreas islets without the "impossible- to-get" injections, and thought DMSO might be the answer. If a mixture of cayenne and DMSO was applied over the pancreas area, it might just transport the cayenne to the islets, and then heal the inflamed nerves. This makes sense to me, but I'm wondering if anyone in this group would agree...???All of the people I know with diabetes seem to be the very careful, do-what-the- doctor-says types. I wish I could find someone who would be willing to try this application. .. Any takers on board??With blessings,Molly Quote Link to comment Share on other sites More sharing options...
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