Diastolic Dysfunction - Herbal help?/Please explain?

[Guest guest]

Doc, Could you please explain what CoQ10 is used for? The gal at

GNC tried to sell me on it for my muscle pain and the first

ingredient on the label was Titanium Dioxide. I use that in my

homemade soaps to make them white. Isn't that the same thing they

put into paint to make it white?? She couldn't tell me what it was

or why it was in there but I was leery to taking it. thanks, tang

 

 

 

herbal remedies , " Debbie " <BeachHunter

wrote:

>

> I am so glad you recommend NOW brand. I buy their product because

they add less adulterants, and were several dollars cheaper than

some brands my HFS stock.

> Debbie

>

> -

> Dr. Ian Shillington

> herbal remedies

> Tuesday, September 12, 2006 12:09 PM

> Re: Herbal Remedies - Diastolic Dysfunction - Herbal

help?

>

>

>

> Do NOT use the vitamins at Walmart under any

circumstances!!!!!!!!!!!

> They are very inferior, and contain items that are not good for

you such as Aspartame. They are also made by Big Pharma industries.

> NOW makes a good CoQ10, and so does Standard Vitamins.

> Read them thar labels.

> In Health, Freedom, and Love,

> Doc

>

> Doc Shillington

> 727-447-5282

> Doc

> -

> Skofeld

> herbal remedies

> Saturday, September 09, 2006 3:14 AM

> Re: Herbal Remedies - Diastolic Dysfunction - Herbal

help?

>

>

> I was just diagnosed with diastolic dysfunction (heart

failure) and wondered if anyone can recommend herbs that may help my

symptoms.

>

> Cayenne pepper & hawthorn berries ( as a syrup and/or

chewed ). Various alcoholic tinctures for the heart are also

available.>>

>

> I'd also suggest going to Walmart vitamin aisle and buying

Hawthorne and also CoQ10. Would suggest the 150mg taken three times

a day and with a fish oil capsule. CoQ10 is oil or fat soluble and

needs some oil in your gut in order for it to be absorbed. Vit E is

also oil soluble and suggest 2 capsules a day taken with the fish

oil and CoQ10. Hawthorne is very inexpensive and it is not oil

soluble, so that pill can be taken with just some water.

>

> .

>

[Guest guest]

Coenzyme Q10 (CoQ 10) or ubiquinone is essentially a vitamin or vitamin-like substance. Disagreements on nomenclature notwithstanding, vitamins are defined as organic compounds essential in minute amounts for normal body function acting as coenzymes or precursors to coenzymes. They are present naturally in foods and sometimes are also synthesized in the body. CoQ10 likewise is found in small amounts in a wide variety of foods and is synthesized in all tissues. The biosynthesis of CoQ10 from the amino acid tyrosine is a multistage process requiring at least eight vitamins and several trace elements. Coenzymes are cofactors upon which the comparatively large and complex enzymes absolutely depend for their function. Coenzyme Q10 is the coenzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell. Mitochondrial enzymes of the oxidative phosphorylation pathway are essential for the production of the high-energy phosphate, adenosine triphosphate (ATP), upon which all cellular functions depend. The electron and proton transfer functions of the quinone ring are of fundamental importance to all life forms; ubiquinone in the mitochondria of animals, plastoquinone in the chloroplast of plants, and menaquinone in bacteria. The term "bioenergetics" has been used to describe the field of biochemistry looking specifically at cellular energy production. In the related field of free radical chemistry, CoQ10 has been studied in its reduced form (Fig. 1) as a potent antioxidant. The bioenergetics and free radical chemistry of CoQ10 are reviewed in Gian Paolo Littarru's book, Energy and Defense, published in 1994(1).

HISTORY

CoQ10 was first isolated from beef heart mitochondria by Dr. Frederick Crane of Wisconsin, U.S.A., in 1957 (2). The same year, Professor Morton of England defined a compound obtained from vitamin A deficient rat liver to be the same as CoQ10(3). Professor Morton introduced the name ubiquinone, meaning the ubiquitous quinone. In 1958, Professor Karl Folkers and coworkers at Merck, Inc., determined the precise chemical structure of CoQ10: 2,3 dimethoxy-5 methyl-6 decaprenyl benzoquinone (Fig. 1), synthesized it, and were the first to produce it by fermentation. In the mid-1960's, Professor Yamamura of Japan became the first in the world to use coenzyme Q7 (a related compound) in the treatment of human disease: congestive heart failure. In 1966, Mellors and Tappel showed that reduced CoQ6 was an effective antioxidant (4,5). In 1972 Gian Paolo Littarru of Italy along with Professor Karl Folkers documented a deficiency of CoQ10 in human heart disease (6). By the mid-1970's, the Japanese perfected the industrial technology to produce pure CoQ10 in quantities sufficient for larger clinical trials. Peter Mitchell received the Nobel Prize in 1978 for his contribution to the understanding of biological energy transfer through the formulation of the chemiosmotic theory, which includes the vital protonmotive role of CoQ10 in energy transfer systems (7,8,9,10).

In the early 1980's, there was a considerable acceleration in the number and size of clinical trials. These resulted in part from the availability of pure CoQ10 in large quantities from pharmaceutical companies in Japan and from the capacity to directly measure CoQ10 in blood and tissue by high performance liquid chromatography. Lars Ernster of Sweden, enlarged upon CoQ10's importance as an antioxidant and free radical scavenger (11). Professor Karl Folkers went on to receive the Priestly Medal from the American Chemical Society in 1986 and the National Medal of Science from President Bush in 1990 for his work with CoQ10 and other vitamins.

COENZYME Q10 DEFICIENCY

Normal blood and tissue levels of CoQ10 have been well established by numerous investigators around the world. Significantly decreased levels of CoQ10 have been noted in a wide variety of diseases in both animal and human studies. CoQ10 deficiency may be caused by insufficient dietary CoQ10, impairment in CoQ10 biosynthesis, excessive utilization of CoQ10 by the body, or any combination of the three. Decreased dietary intake is presumed in chronic malnutrition and cachexia(12).

The relative contribution of CoQ10 biosynthesis versus dietary CoQ10 is under investigation. Karl Folkers takes the position that the dominant source of CoQ10 in man is biosynthesis. This complex, 17 step process, requiring at least seven vitamins (vitamin B2 - riboflavin, vitamin B3 - niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C, and pantothenic acid) and several trace elements, is, by its nature, highly vulnerable. Karl Folkers argues that suboptimal nutrient intake in man is almost universal and that there is subsequent secondary impairment in CoQ10 biosynthesis. This would mean that average or "normal" levels of CoQ10 are really suboptimal and the very low levels observed in advanced disease states represent only the tip of a deficiency "ice berg".

HMG-CoA reductase inhibitors used to treat elevated blood cholesterol levels by blocking cholesterol biosynthesis also block CoQ10 biosynthesis(13). The resulting lowering of blood CoQ10 level is due to the partially shared biosynthetic pathway of CoQ10 and cholesterol. In patients with heart failure this is more than a laboratory observation. It has a significant harmful effect which can be negated by oral CoQ10 supplementation(14).

Increased body consumption of CoQ10 is the presumed cause of low blood CoQ10 levels seen in excessive exertion, hypermetabolism, and acute shock states. It is likely that all three mechanisms (insufficient dietary CoQ10, impaired CoQ10 biosynthesis, and excessive utilization of CoQ10) are operable to varying degrees in most cases of observed CoQ10 deficiency.

TREATMENT OF HEART DISEASE WITH COENZYME Q10

CoQ10 is known to be highly concentrated in heart muscle cells due to the high energy requirements of this cell type. For the past 14 years, the great bulk of clinical work with CoQ10 has focused on heart disease. Specifically, congestive heart failure (from a wide variety of causes) has been strongly correlated with significantly low blood and tissue levels of CoQ10 (15). The severity of heart failure correlates with the severity of CoQ10 deficiency (16). This CoQ10 deficiency may well be a primary etiologic factor in some types of heart muscle dysfunction while in others it may be a secondary phenomenon. Whether primary, secondary or both, this deficiency of CoQ10 appears to be a major treatable factor in the otherwise inexorable progression of heart failure.

Pioneering trials of CoQ10 in heart failure involved primarily patients with dilated weak heart muscle of unknown cause (idiopathic dilated cardiomyopathy). CoQ10 was added to standard treatments for heart failure such as fluid pills (diuretics), digitalis preparations (Lanoxin), and ACE inhibitors. Several trials involved the comparison between supplemental CoQ10 and placebo on heart function as measured by echocardiography. CoQ10 was given orally in divided doses as a dry tablet chewed with a fat containing food or an oil based gel cap swallowed at mealtime. Heart function, as indicated by the fraction of blood pumped out of the heart with each beat (the ejection fraction), showed a gradual and sustained improvement in tempo with a gradual and sustained improvement in patients' symptoms of fatigue, dyspnea, chest pain, and palpitations. The degree of improvement was occasionally dramatic with some patients developing a normal heart size and function on CoQ10 alone. Most of these dramatic cases were patients who began CoQ10 shortly after the onset of congestive heart failure. Patients with more established disease frequently showed clear improvement but not a return to normal heart size and function

Doc Shillington727-447-5282Doc

 

-

tangj2

herbal remedies

Tuesday, September 12, 2006 7:48 PM

Re: Herbal Remedies - Diastolic Dysfunction - Herbal help?/Please explain?

 

 

Doc, Could you please explain what CoQ10 is used for? The gal at GNC tried to sell me on it for my muscle pain and the first ingredient on the label was Titanium Dioxide. I use that in my homemade soaps to make them white. Isn't that the same thing they put into paint to make it white?? She couldn't tell me what it was or why it was in there but I was leery to taking it. thanks, tangherbal remedies , "Debbie" <BeachHunter wrote:>> I am so glad you recommend NOW brand. I buy their product because they add less adulterants, and were several dollars cheaper than some brands my HFS stock.> Debbie> > - > Dr. Ian Shillington > herbal remedies > Tuesday, September 12, 2006 12:09 PM> Re: Herbal Remedies - Diastolic Dysfunction - Herbal help?> > > > Do NOT use the vitamins at Walmart under any circumstances!!!!!!!!!!!> They are very inferior, and contain items that are not good for you such as Aspartame. They are also made by Big Pharma industries.> NOW makes a good CoQ10, and so does Standard Vitamins.> Read them thar labels.> In Health, Freedom, and Love,> Doc> > Doc Shillington> 727-447-5282> Doc - > Skofeld > herbal remedies > Saturday, September 09, 2006 3:14 AM> Re: Herbal Remedies - Diastolic Dysfunction - Herbal help?> > > I was just diagnosed with diastolic dysfunction (heart failure) and wondered if anyone can recommend herbs that may help my symptoms. > > Cayenne pepper & hawthorn berries ( as a syrup and/or chewed ). Various alcoholic tinctures for the heart are also available.>> > > I'd also suggest going to Walmart vitamin aisle and buying Hawthorne and also CoQ10. Would suggest the 150mg taken three times a day and with a fish oil capsule. CoQ10 is oil or fat soluble and needs some oil in your gut in order for it to be absorbed. Vit E is also oil soluble and suggest 2 capsules a day taken with the fish oil and CoQ10. Hawthorne is very inexpensive and it is not oil soluble, so that pill can be taken with just some water. > > .>