MCS researcher Martin Pall published at The Townsend

[Guest guest]

MCS researcher Martin Pall published at The Townsend

_http://www.thecanaryreport.org/2010/02/25/mcs-researcher-martin-pall-publis

hed-at-the-townsend/?utm_source=feedburner & utm_medium=email & utm_campaign=Fee

d%3A+TheCanaryReport+%28The+Canary+Report%29_

(http://www.thecanaryreport.org/2010/02/25/mcs-researcher-martin-pall-published-\

at-the-townsend/?utm_sourc

e=feedburner & utm_medium=email & utm_campaign=Feed:+TheCanaryReport+(The+Canary

+Report))

 

 

Multiple Chemical Sensitivity researcher Martin L. Pall’s paper, “How Can

We Cure NO/ONOO- Cycle Diseases? Approaches to Curing Chronic Fatigue

Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical

Sensitivity, Gulf War Syndrome and Possibly Many Others,†is published in the

February/March 2010 issue of The Townsend Letter: The Examiner of Alternative

Medicine. Pall is Professor Emeritus of Biochemistry and Basic Medical Science

at Washington State University.

 

 

The _entire essay_

(http://www.townsendletter.com/FebMarch2010/cureNO0210.html) is published at

the Townsend, here’s an excerpt:

 

The NO/ONOO- cycle is a biochemical vicious cycle that is thought to cause

such diseases as chronic fatigue syndrome/myalgic encephalomyelitis

(CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM), and possibly

a

large number of other chronic inflammatory diseases. The

chemistry/biochemistry of the cycle predicts that the primary mechanism is local

such the

depending on where it is localized in the body, it may cause a variety of

different diseases.

 

Previous studies have shown that agents that lower such cycle elements as

oxidative stress, nitric oxide, inflammatory responses, mitochondrial

dysfunction, tetrahydrobiopterin (BH4) depletion and NMDA activity produce

clinical improvements in CFS/ME and FM patients, consistent with the

predictions

of the cycle mechanism. Multiagent protocols lowering several aspects of

the cycle appear to be the most promising approaches to therapy. These

include an entirely over-the-counter nutritional support protocol developed by

the author in conjunction with the Allergy Research Group.

 

However, such mulitagent protocols to date have not produced any

substantial numbers of cures of these presumed NO/ONOO- cycle disease. Why is

that?

This paper argues that what is called the central couplet of the cycle, the

reciprocal relation between peroxynitrite elevation and BH4 depletion, is

not being adequately downregulated by these multiagent protocols. Ten

agents/classes of agents are available, each of which downregulates one or the

other end of this central couplet. It is suggested, then, that treatments

that simultaneously effectively downregulate both ends to the central couplet,

when used along with multiagent protocols lowering other aspects of the

cycle and avoidance of stressors that otherwise upregulate the cycle, will

lead to substantial numbers of cures of these chronic diseases

 

 

It’s very exciting to see Pall published at The Townsend. I think he’s on

the leading edge of MCS research, and I urge you to _learn more about his

findings_ (http://thetenthparadigm.org/index.html) .

 

 

A major paper on Multiple Chemical Sensitivity by Pall (at left) was

published last year as chapter XX in a prestigious reference work for

professional toxicologists, _General and Applied Toxicology, 3rd Edition_

(http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470723270.html) (2009,

John

Wiley & Sons). Pall’s paper, entitled “Multiple Chemical Sensitivity:

Toxicological Questions and Mechanisms,†establishes _five important facts

about

MCS:_

(http://www.thecanaryreport.org/2009/10/18/published-research-shows-multiple-che\

mical-sensitivity/) :

 

1) MCS is common;

2) MCS is caused by toxic chemical exposure;

3) the role of chemicals acting as toxicants in MCS has been confirmed by

genetic studies; 4) there is a detailed and generally well supported

mechanism for MCS, the NO/ONOO- cycle; and

5) MCS is a physiological disease initiated by toxic chemical exposure

that has been falsely claimed to be psychogenic.

 

Pall is located on Pacific time in the U.S. and can be contacted at:

503-232-3883 and at _martin_pall_ (martin_pall) . His web

site is: thetenthparadigm.org. _http://thetenthparadigm.org/index.html_

(http://thetenthparadigm.org/index.html)

 

 

3 Responses:

 

 

by Aylwin Catchpole

Myalgic Encephalomyelitis is caused by an infectious Enterovirus, the same

family of viruses that caused Polio. The NO/ONOO changes are a result &

not a cause of ME. It also can cause MCS & many allergies etc. I am sure that

treating this aspect could be helpful, but in the particular case of ME,

will not undo the Brain Stem damage nor remove the Enteroviral infection.

Dr. Pall is indeed doing great work, but is only looking at the “one bit of

the elephant†in ME, at the expense of the core cause. Please see hfme.org

for more info.

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by Susie Collins

Aloha Aylwin, I held your comment in moderation until I could consult with

Martin Pall about your assertions. This is his response to your comment:

 

 

The following is my response to Aylwin Catchpole’s undocumented claims.

There have been many attempts to argue that CFS/ME is simply a response to

infection by a specific infectious agent, but none of them has ever been shown

to fulfill Koch’s postulates or any modern version of Koch’s postulates.

Consequently, his claim that enterovirus is THE cause is not supported by

the literature. What is true is that we have substantial support that CFS/ME

has a very good fit to the five principles underlying the NO/ONOO- cycle.

These five principles are the rough equivalent of Koch’s postulates for

NO/ONOO- cycle diseases. So here we do have substantial and I would argue

overwhelming evidence that the NO/ONOO- cycle is causal.

 

 

There is specific substantial specific published evidence that contradicts

Aylwin Catchpole’s claim – evidence from the pattern of stressors shown to

be able to initiate cases of CFS/ME, evidence from genetic studies of

susceptibility, implicating excessive superoxide levels, mitochondrial

dysfunction and also inflammatory biochemistry as causal elements and also a

various clinical trial studies of potential therapeutic agents also implicating

these factors and other elements of the cycle as causal elements in CFS/ME.

If Aylwin Catchpole wishes to argue with all of this evidence, he is free

to publish his arguments but at this point, we must view the foundation of

his comments as being based on quicksand.

 

 

One more point, the web site that he cites does not provide any evidence

whatsoever supporting his view. It simply provides unsupported opinion, and

unsupported opinion is never the basis of good science.

 

Martin L. Pall, PhD

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by Lourdes

Thank you for sharing this important research with everyone Susie!

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