Undenatured Type II Collagen – Chicken Soup for Your Joints

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Undenatured Type II Collagen – Chicken Soup for Your Joints

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Undenatured chicken collagen, the primary ingredient in OsteoTec™ UC·II®,

has been shown in studies and trials to help the body repair and rebuild

joint cartilage - reducing joint pain, increasing joint mobility and

flexibility, and promoting long-term joint health.

 

 

Grandmothers around the world have been treating colds with chicken soup

for generations; then a few years ago scientists confirmed that several

ingredients in chicken soup do, indeed, affect the immune system. What grandma

didn't realize, though, is that one part of the chicken in particular may

also help ameliorate the joint pain of arthritis.

 

 

Taken from the chicken's sternum cartilage, UC·II is an innovative,

patented form of undenatured type II collagen that works with the immune system

to reduce inflammation and restore cartilage (unlike glucosamine &

chondroitin, which are materials involved in the structure of healthy

cartilage).

Extensive research and clinical studies have shown UC·II to be both safe and

effective in supporting joint health – and clarify how it helps the body

derail a destructive process involved in both types of arthritis.

 

 

Like Grandma's Cold Remedy, UC·II was Discovered in the Kitchen.

 

 

Dr. Eugene Moore, a chemical engineer, had an 8-year-old daughter, Anne

Marie, who was diagnosed with rheumatoid arthritis. Her swollen and painful

joints continued to worsen until, by the time she was in her late 20's, much

of her life was spent in an electric wheelchair.

 

 

One day Dr. Moore read about some studies on chicken collagen which showed

that a small amount taken orally could have a preventive effect on

rheumatoid arthritis. Putting his chemical engineering background to work, he

went

to the grocery, bought some chickens, and turned his kitchen into a

laboratory. What Dr. Moore discovered was that, unlike grandma's chicken soup,

if

he cooked the chicken collagen, it became ineffective. So he formulated a

recipe for an ‘undenatured’ (also called natural or native; not processed

by high heat or chemicals) chicken collagen using the chicken's sternum

cartilage.

 

 

After his daughter's rheumatoid arthritis began to improve, Dr. Moore

shared his preparation with his good friend, Roger, who suffered with

osteoarthritis so severe he could no longer function normally. Within a few

weeks,

Roger, too, began to feel and function much better. Both Anne Marie and

Roger described the results as extraordinary - a significantly improved quality

of life with no side effects.

 

 

Since Dr. Moore's initial discovery, a number of other studies have

confirmed the benefits of undenatured type II collagen for joint health in both

humans and animals.

 

 

Trial Shows UC·II More Than Twice as Effective as Glucosamine and

Chondroitin

 

 

In a randomized, double-blind study of 52 osteoarthritis patients, one

group took 40 mg UC·II and the other a combination of 1500 mg glucosamine and

1200 mg chondroitin. (Double-blind means neither the study subjects nor

those tracking the results knew which patients were receiving which doses.)

The table below shows the results after 90 days (percentages indicate the

reduction in symptomatology):

 

[ GRAPH ]

 

Symptom UC·II G & C Stiffness and difficulty in physical function

33.3% less 14.0% less General level of pain 40.4% less 15.4% less Effect of

pain on daily activities 20.2% less 5.9% less

 

 

A small daily dosage of UC·II reduced joint pain and increased joint

mobility and flexibility significantly - more than twice as much as the larger

dosages of glucosamine and chondroitin.(1)

 

 

Additional Human Clinical Trials

 

 

-- A pilot study looked at five women who had significant joint pain

symptoms. Each took 40 mg of UC·II for 42 days. Four of the five reported

significant reductions in pain and stiffness. The average reduction in pain

level

was 26 percent.(2)

 

-- Six out of 10 rheumatoid arthritis patients reported significant

improvement after taking UC·II for three months. One patient experienced

complete

remission. No side effects were reported.(3)

 

-- In a 90-day, double-blind, placebo-controlled study, 60 patients with

severe, active rheumatoid arthritis were split into two groups. In the half

taking UC·II, 28 showed considerable improvement compared to the placebo

group. Four patients recovered completely.(3)

 

-- Ten children (8 to 14 years old) with active juvenile rheumatoid

arthritis were given UC·II for three months. Eight of the 10 experienced a

reduction in swollen and tender joints and one experienced a complete

remission.(4)

 

 

Animal Studies

 

 

Humans are not the only ones who suffer the pain of arthritis. One in four

pet dogs in the U.S. is diagnosed with some form of arthritis, as are

millions of horses worldwide. A number of studies have been done using UC·II

to

treat osteoarthritic dogs and horses, with good results. For example:

 

-- Osteoarthritic dogs were given either 40 mg of UC·II or a placebo for

120 days. The dogs given the UC·II exhibited significant improvements as

measured by detailed observation of pain-related behaviors and responses: 77

percent less evidence of overall pain, 83 percent less evidence of pain

after limb manipulation, and 84 percent less pain after exercise. The dogs

receiving the placebo exhibited no significant change in observed pain

behaviors/responses.(5)

 

-- Osteoarthritic horses were divided into groups of five or six,

receiving either 320 mg of UC·II, 480 mg of UC·II, 640 mg of UC-II, 5,400 mg

of

glucosamine plus 1,800 mg of chondroitin, or a placebo. The horses who

received the 320, 480 or 640 mg of UC·II exhibited significant reductions in

arthritic pain. The UC·II dosages of 480 or 640 mg had equal effects - an 88

percent decrease in overall pain and a 78 percent decrease in pain upon limb

manipulation. UC·II was found to be more effective than glucosamine plus

chondroitin.(6)

 

 

How UC·II Works on Rheumatoid Arthritis and Osteoarthritis

 

 

Rheumatoid arthritis is an autoimmune disease in which the body's own

immune system turns against itself, and killer T-cells begin to attack the

joint cartilage, resulting in inflammation and joint destruction.

 

 

UC·II contains molecular regions called epitopes. These are immune system

markers that interact with certain antibodies to trigger the deactivation

of collagen-specific killer T-cells, and in turn help deactivate the

inflammatory process.

 

 

Osteoarthritis is characterized by an inflammatory synovial response that

leads to joint wear and tear and is usually attributed to aging.

 

 

Many of the biochemical markers associated with OA inflammation are also

associated with RA inflammation; therefore similar therapies are usually

used. Research has shown that UC·II suppresses the T-cell-mediated

inflammation in both forms of arthritis.

 

 

Denatured vs. Undenatured – Why the Difference Is Important

 

 

Denatured (hydrolyzed).

As Dr. Moore discovered in his kitchen laboratory, when chicken sternum

collagen is heated, it loses its ability to repair and rebuild the joints.

Most of the type II chicken collagen found in dietary supplements is

denatured or hydrolized, which means that high heat and/or chemicals have been

used

to process it. These processes fundamentally alter the molecular structure

of the protein, rendering the collagen ineffective as an immunomodulator.

There are no peer-reviewed scientific studies showing that denatured type II

collagen provides any joint health benefits. And in fact one study states,

“denatured type II collagen has no observable effect on the incidence and

severity of the disease [arthritis].â€(7)

 

 

Undenatured (native).

Undenatured type II collagen is made using little or no heat and very

limited processing - just enough to concentrate the collagen and make it

soluble. The UC·II manufacturing process ensures that the collagen remains

biologically active in its most native, triple helix form, with its

immunomodulating ability intact.

 

 

The Right Dosage is Essential

 

Although some people think “if a little is good, more must be better,â€

this definitely does not apply to undenatured type II collagen.

 

Small amounts have been found to be the most effective in modulating the

body's immune response, but too much can produce a negative or opposite

result. The daily dosage recommended for maximum effectiveness is 40 mg UC·II

(containing 10 mg bioactive undenatured type II collagen).

 

In addition to the bioactive UC·II undenatured type II collagen, OsteoTec

UC·II contains Aquamin® (mineralized red algae) - a source of calcium plus

more than 70 naturally occurring trace minerals absorbed from the sea;

clinically proven to improve bone and joint health.(8)

 

 

Unique Natural Support for Joint Health & Function

 

 

Overall, clinical trials and studies strongly support OsteoTec UC·II's

unique ability to work with the immune system naturally, often helping to

defuse the destructive inflammatory processes responsible for stiffness and

pain in both rheumatoid and osteoarthritis.

 

 

References:

 

 

1. Bagchi M, et al. Beneficial effects of oral administration of

undenatured type-II collagen on osteoarthritis: a human clinical trial.

Presented

at: Journal of the American College of Nutrition 49th Annual Meeting; October

2008; Arlington, Va. Abstract No. 30. (See also Crowley DC, et al. _Safety

and efficacy of undenatured type II collagen in the treatment of

osteoarthritis of the knee: A clinical trial_

(http://www.medsci.org/v06p0312.htm) .

International Journal of Medical Sciences, 2009;6:312-321. November 2009)

 

 

2. Bagchi D, et al. _Effects of orally administered undenatured type II

collagen against arthritic inflammatory diseases: a mechanistic exploration_

(http://www.ncbi.nlm.nih.gov/pubmed/12837047) .. Int J Clin Pharmacol Res.

22(3-4):101-10, 2002.

 

 

3. Trentham D, et al. _Effects of Oral Administration of Type-II Collagen

on Rheumatoid Arthritis_

(http://www.sciencemag.org/cgi/content/abstract/sci;261/5129/1727) . Science.

261:1727-1730, 1993.

 

 

4. Barnett, et al. _A Pilot Trial of Oral Type-II Collagen in the

Treatment of Juvenile Rheumatoid Arthritis_

(http://www3.interscience.wiley.com/journal/112212995/abstract) Arthritis &

Rheumatism. 39:623-628, 1996.

 

 

5. Gupta RC, et al. Pain reduction measured by ground force plate in

arthritic dogs treated with type-II collagen. Presented at: Society of

Toxicology 48th Annual Meeting; March 2009. (See also: D’Altilio M, et al.

Therapeutic efficacy and safety of undenatured type II collagen singly or in

combination with glucosamine and chondroitin in arthritic dogs. Toxicol Mech

Methods. 17:189-196, 2007; and Deparle LA, et al. _Efficacy and safety of

glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs_

(http://www3.interscience.wiley.com/journal/118693780/abstract?CRETRY=1 & SRETRY

=0) . J Vet Pharmacol Therap. 28:385-390, 2005.)

 

 

6. Gupta RC, et al. _Therapeutic efficacy of undenatured type-II collagen

(UC-II) in comparison to glucosamine and chondroitin in arthritic horses_

(http://www.fasebj.org/cgi/content/meeting_abstract/22/2_MeetingAbstracts/659)

. J Vet Pharmacol Therap. 32:577-584, 2009.

 

 

7. Nagler-Anderson C, et al. _Suppression of type II collagen-induced

arthritis by intragastric administration of soluble type II collagen_

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC386734/) . Proc Natl Acad Sci USA.

83:7443-7446, 1986.

 

 

8. Frestedt, JL, et al. _A Natural mineral supplement [Aquamin] provides

relief from knee osteoarthritis symptoms: a randomized controlled pilot

trial_ (http://www.nutritionj.com/content/7/1/9) . Nutrition Journal, 7(9),

2008.

 

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Note: This information has not been evaluated by the FDA. It is general

and is not meant to prevent, diagnose, treat or cure any condition, illness,

or disease. It is very important that you make no change in your healthcare

plan or health support regimen without researching and discussing it in

collaboration with your professional healthcare team.