Magnesium in Neurological Diseases and Emotions

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Magnesium in Neurological Diseases and Emotions

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iseases-and-emotions/_

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ses-and-emotions/)

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Even a mild deficiency of magnesium can cause increased sensitivity to

noise, nervousness, irritability, mental depression, confusion, twitching,

trembling, apprehension, and insomnia. Imagine being able to clear these

symptoms without dangerous drugs! Magnesium is the premier medicine for

depression, sleep disturbances, emotionally disturbed behavior, and

neurological

diseases because of its strong positive effect in calming and nourishing the

nervous system.

 

 

Evidence is mounting that low levels of magnesium contribute to the heavy

metal deposition in the brain that precedes Parkinson’s, multiple sclerosis

and Alzheimer’s. Many of the symptoms of Parkinson’s disease can be

overcome with high magnesium supplementation. In a trial with 30 epileptics 450

mg of magnesium supplied daily successfully controlled seizures. Another

study found that the lower the magnesium blood levels the more severe was the

epilepsy. In most cases magnesium works best in combination with vitamin

B6 and zinc.

 

 

Magnesium is essential in regulating central nervous system excitability

thus magnesium-deficiency may cause aggressive behavior[1], depression, or

suicide.[2] Magnesium calms the brain and people do not need to become

severely deficient in magnesium for the brain to become hyperactive. One

study[3] confirmed earlier reports that a marginal magnesium intake overexcites

the brain’s neurons and results in less coherence–creating cacophony rather

than symphony—according to electroencephalogram (EEG) measurements.[4]

 

 

If magnesium is severely deficient, the brain is particularly affected.

Clouded thinking, confusion, disorientation, marked depression and even the

terrifying hallucinations of delirium are largely brought on by a lack of

this nutrient and remedied when magnesium is given. Symptoms that multiple

sclerosis (MS) has in common with magnesium deficiency include muscle

spasms, weakness, twitching, muscle atrophy, incontinence, nystagmus (rapid eye

movements), hearing loss, and osteoporosis. People with MS also have higher

rates of epilepsy than controls, which have been linked to magnesium

deficiencies. [5]

 

 

Women’s bodies are known to crave for chocolate during PMS. Some

researchers believe that women crave chocolate prior to menstruation because it

contains magnesium. The medical journal for the American Heart Association

created a stir when it reported a study of 22 heart transplant patients who

were given a dose of dark chocolate or fake chocolate. Just two hours after

eating the real thing, patients had measurable improvements in blood flow,

vascular function, and less clotting, compared to placebo chocolate eaters

who experienced no change.

 

 

Chocolate cravings are potentially a sign of a magnesium deficiency since

chocolate is high in magnesium. Though it is widely accepted that chocolate

affects our moods, few make the correlation between magnesium and

emotions. People often report when eating chocolate that their mood is elevated

and

they feel better. This elevation in mood is temporary and when the effect

wears off, subjects again reverted to their previous state of mind. The

mood changing effect is greater when magnesium is used medicinally in high

doses, which is most efficiently administered transdermally. Chocolate is not

high enough in magnesium to be used medicinally and would be undesirable

because of the high sugar component of most chocolates. Natural magnesium

chloride (magnesium oil) is more effective to raise cellular magnesium levels

to affect moods positively.

 

 

Magnesium deficiency or imbalance plays a crucial role in the symptoms of

mood disorders. Observational and experimental studies have shown an

association between magnesium and aggression, [6],[7],[8],[9],[10], anxiety,

[11],[12],[13], ADHD, [14],[15],[16],[17], bipolar disorder, [18],[19],

depression [20],[21],[22],[23] and schizophrenia [24],[25],[26],[27]. The two

most basic requirements for the normal operation of our brain are a

sufficient energy supply and an optimal presence of biochemicals involved in

transmitting messages. Magnesium is crucial in both the production of energy

and

neurotransmitters, and the integrity of the blood brain barrier. Solid

neuroscience connects magnesium to neurological disorders. [28]

 

 

Depression and other emotional disorders of the heart are addressed most

directly with magnesium. There is a definite link between how we feel and

the condition of our cells. If we think of our cells as a microcosm of our

total self, then we can see how cellular degeneration can affect every aspect

of our being. When our cells are open, permeable and healthy we feel

happy, energetic and optimistic. But when our cells become rigid (from excess

calcium and insufficient magnesium) they become closed off and toxic, which

can lead us to feel depressed with low energy and pessimistic moods. The

condition of our cells will affect us physically, emotionally, and

spiritually.

 

 

The healthy cell is permeable. This means that nutrients are able to pass

into them efficiently to be absorbed and the toxic byproducts of metabolism

are eliminated. When the cells are healthy the polarity of the cell is

correct, i.e., there is intracellular potassium and magnesium as well as

extracellular sodium and calcium. The cell in this state is healthy, and the

person functions optimally both physically and emotionally. The unhealthy cell

is not permeable. This leads to unhealthy cells with sodium and calcium

going inside the cell, and magnesium and potassium being lost.

 

 

Mark Sircus Ac., OMD International Medical Veritas Association

_http://publications.imva.info_ (http://publications.imva.info/) Email:

_director_ (director)

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[1] Bernard Rimland. While no patient has been cured with the vitamin B6

and magnesium treatment, there have been many instances where remarkable

improvement has been achieved. In one such case an 18-year-old autistic

patient was about to be evicted from the third mental hospital in his city.

Even

massive amounts of drugs had no effect on him, and he was considered too

violent and assaultative to be kept in the hospital. The psychiatrist tried

the B6/magnesium approach as a last resort. The young man calmed down very

quickly. The psychiatrist reported at a meeting that she had recently visited

the family and had found the young man to now be a pleasant and easy-going

young autistic person who sang and played his guitar for her.

_http://www.autism.org/vitb6.html_ (http://www.autism.org/vitb6.html)

 

[2] C. M. Banki, M. Arato and C. D. Kilts. Aminergic studies and

cerebrospinal fluid cations in suicide. Annals of the New York Academy of

Sciences,

Vol 487, Issue 1 221-230, Copyright © 1986 by New York Academy of Sciences

 

[3] This is the first experimental study in which magnesium intakes were

tightly controlled and EEG measurements were analyzed by computer so they

could be statistically compared.

 

[4] _http://www.ars.usda.gov/is/np/fnrb/fnrb1095.htm#calm_

(http://www.ars.usda.gov/is/np/fnrb/fnrb1095.htm#calm)

 

[5] _http://www.nhfw.info/magnesium.html_

(http://www.nhfw.info/magnesium.html)

 

[6] Izenwasser SE et al. Stimulant-like effects of magnesium on aggression

in mice. Pharmacol Biochem Behav 25(6):1195-9, 1986.

 

[7] Henrotte JG. Type A behavior and magnesium metabolism. Magnesium

5:201-10, 1986.

 

[8] Bennett CPW, McEwen LM, McEwen HC, Rose EL. The Shipley Project:

treating food allergy to prevent criminal behaviour in community settings. J

Nutr Environ Med 8:77-83, 1998.

 

[9] Kirow GK, Birch NJ, Steadman P, Ramsey RG. Plasma magnesium levels in

a population of psychiatric patients: correlation with symptoms.

Neuropsychobiology 30(2-3):73-8, 1994.

 

[10] Kantak KM. Magnesium deficiency alters aggressive behavior and

catecholamine function. Behav Neurosci 102(2):304-11, 1988

 

[11] Buist RA. Anxiety neurosis: The lactate connection. Int Clin Nutr Rev

5:1-4, 1985.

 

[12] Seelig MS, Berger AR, Spieholz N. Latent tetany and anxiety, marginal

Mg deficit, and normocalcemia. Dis Nerv Syst 36:461-5, 1975.

 

[13] Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics.

Magnes Res 7(3/4):313-28, 1994.

 

[14] Durlach J. Clinical aspects of chronic magnesium deficiency, in MS

Seelig, Ed. Magnesium in Health and Disease. New York, Spectrum Publications,

1980.

 

[15] Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in

children with attention deficit hyperactivity disorder (ADHD). Magnes Res

10(2):143-8, 1997.

 

[16] Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in

children with attention deficit hyperactivity disorder (ADHD). Magnes Res

10(2):143-8, 1997.

 

[17] Starobrat-Hermelin B, Kozielec T. The effects of magnesium

physiological supplementation on hyperactivity in children with attention

deficit

hyperactivity disorder (ADHD). Positive response to magnesium oral loading

test. Magnes Res 10(2):149-56, 1997.

 

[18] George MS, Rosenstein D, Rubinow DR, et al. CSF magnesium in

affective disorder: lack of correlation with clinical course of treatment.

Psychiatry Res 51(2):139-46, 1994.

 

[19] Kirov GK, Birch NJ, Steadman P, Ramsey RG. Plasma magnesium levels in

a population of psychiatric patients: correlations with symptoms.

Neuropsychobiology 1994;30(2-3):73-8, 1994.

 

[20] Linder J et al. Calcium and magnesium concentrations in affective

disorder: Difference between plasma and serum in relation to symptoms. Acta

Psychiatr Scand 80:527-37, 1989

 

[21] Frazer A et al. Plasma and erythrocyte electrolytes in affective

disorders. J Affect Disord 5(2):103-13, 1983.

 

[22] Bjorum N. Electrolytes in blood in endogenous depression. Acta

Psychiatr Scand 48:59-68, 1972.

 

[23] Cade JFJA. A significant elevation of plasma magnesium levels in

schizophrenia and depressive states. Med J Aust 1:195-6, 1964.

 

[24] Levine J, Rapoport A, Mashiah M, Dolev E. Serum and cerebrospinal

levels of calcium and magnesium in acute versus remitted schizophrenic

patients. Neuropsychobiology 33(4):169-72, 1996.

 

[25] Kanofsky JD et al. Is iatrogenic hypomagnesemia common in

schizophrenia? Abstract. J Am Coll Nutr 10(5):537, 1991.

 

[26] Kirov GK, Tsachev KN. Magnesium, schizophrenia and manic-depressive

disease. Neuropsychobiology 23(2):79-81, 1990.

 

[27] Chhatre SM et al. Serum magnesium levels in schizophrenia. Ind J Med

Sci 39(11):259-61, 1985.

 

[28] Murck H. Magnesium and Affective Disorders. Nutr Neurosci.,

2002;5:375-389: Murck showed many actions of magnesium ions supporting their

possible therapeutic potential in affective disorders. Examinations of the

sleep-electroencephalogram (EEG) and of endocrine system points to the

involvement

of the limbic-hypothalamus-pituitary-adrenocortical axis because magnesium

affects all elements of this system. Magnesium has the property to

suppress hippocampal kindling, to reduce the release of adrenocorticotrophic

hormone (ACTH) and to affect adrenocortical sensitivity to ACTH. The role of

magnesium in the central nervous system could be mediated via the

N-methyl-D-aspartate-antagonistic, g-aminobutyric acid A-agonistic or the

angiotensin

II-antagonistic property of this ion. A direct impact of magnesium on the

function of the transport protein p-glycoprotein at the level of the

blood-brain barrier has also been demonstrated, possibly influencing the access

of

corticosteroids to the brain. Furthermore, magnesium dampens the calcium

ion-protein kinase C related neurotransmission and stimulates the Na-K-ATPase.

All these systems have been reported to be involved in the pathophysiology

of depression. Murck et al. also demonstrated induced magnesium deficiency

in mice to produce depression-like behavior which was beneficially

influenced with antidepressants