The pathophysiology of the acute phase of human bartonellosis resembles AIDS.

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_Med Hypotheses._ (javascript:AL_get(this, 'jour', 'Med Hypotheses.')

2010 Jan;74(1):45-9. Epub 2009 Aug 7.

The pathophysiology of the acute phase of human bartonellosis resembles

AIDS.

_http://www.ncbi.nlm.nih.gov/pubmed/19665314_

(http://www.ncbi.nlm.nih.gov/pubmed/19665314)

 

_Ticona E_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Ticona%20E " [Author] & itool=EntrezSystem\

2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract) ,

_Huaroto L_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Huaroto%20L " [Author] & itool=EntrezSyste\

m2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract) ,

_Garcia Y_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Garcia%20Y " [Author] & itool=EntrezSystem\

2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract) ,

_Vargas L_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Vargas%20L " [Author] & itool=EntrezSystem\

2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract) ,

_Madariaga MG_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Madariaga%20MG " [Author] & itool=EntrezSy\

stem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract) .

Servicio de Enfermedades Infecciosas, Hospital Nacional Dos de Mayo,

Parque Historia de la Medicina Peruana s/n, Lima 01, Peru. eticonacrg

 

Human bartonellosis is a South American anthroponosis caused by Bartonella

bacilliformis. The disease has an acute phase characterized by invasion of

red blood cells by parasites, and consequent severe anemia; and a chronic

phase presenting with benign vascular tumors. During the acute phase,

affected individuals are prone to developing opportunistic infections with a

variety of organisms similar to the ones seen in AIDS. After antibiotic

treatment is instituted, a subgroup of patients may develop atypical symptoms

which potentially represent clinical manifestations of the restoration of

macrophage function. We speculate that the pathophysiology of the acute phase of

human bartonellosis resembles AIDS, with a period of immunosuppression

following the infection and later, clinical manifestations of immune

reconstitution subsequent to treatment.

PMID: 19665314 [PubMed - in process]