Association between fibromyalgia and below-normal levels of urinary cortisol

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_http://www.ncbi.nlm.nih.gov/pubmed/19102778?dopt=AbstractPlus_

(http://www.ncbi.nlm.nih.gov/pubmed/19102778?dopt=AbstractPlus)

BMC Res Notes. 2008 Dec 22;1(1):134. [Epub ahead of print]

 

Is there an association between fibromyalgia and below-normal levels of

urinary cortisol?

_Izquierdo Alvarez S_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Izqu\

ierdo%20Alvarez%20S " [Author] & itool=EntrezSystem2.P

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlu

s) , _Bocos Terraz JP_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Boco\

s%20Terraz%20JP " [Author] & itool=EntrezSystem2.PEnt

rez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)

, _Bancalero Flores JL_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Banc\

alero%20Flores%20JL " [Author] & itool=EntrezSystem2

..PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractP

lus) , _Pavon Romero L_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Pavo\

n%20Romero%20L " [Author] & itool=EntrezSystem2.PEnt

rez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)

, _Serrano Ostariz E_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Serr\

ano%20Ostariz%20E " [Author] & itool=EntrezSystem2.PEn

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)

, _Alegre de Miquel C_

(http://www.ncbi.nlm.nih.gov/pubmed/sites/entrez?Db=pubmed & Cmd=Search & Term= " Aleg\

re%2

0de%20Miquel%20C " [Author] & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel\

..Pubmed_DiscoveryPanel.Pubmed_RVAbstract

Plus) .

 

ABSTRACT:

BACKGROUND:

Adynamia in fibromyalgia (FM) may be an expression of a functional deficit

of the hypothalamic-pituitary-adrenal axis and be associated with

below-normal levels of urinary cortisol. Our aim was to demonstrate that

urinary

cortisol was lower in patients with FM than in healthy subjects. FINDINGS: We

measured urinary cortisol levels for a sample of 47 women aged 29 to 64

years (mean age 53 years), diagnosed with FM 2-3 years previously, and

compared the results with those for a control sample of 58 healthy women of a

similar age. Samples of 24-hour urine were appropriately collected and levels

of urinary cortisol were measured using the fluorescence polarization

immunoassay method. The mean cortisol value for the women with FM was

65.40+/-27.10 microg/L, significantly lower than the mean cortisol level for

the

control group, at 90.83+/-38.17 microg/L (p < 0.001). CONCLUSION: Our study

confirms that women with FM have significantly lower urinary cortisol levels

than healthy women.

 

PMID: 19102778 [PubMed - as supplied by publisher]

 

 

 

 

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