Leading European Oncologist Discusses Systemic Oral Enzyme Therapy and Cancer

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Leading European Oncologist Discusses Systemic Oral Enzyme Therapy and

Cancer

_http://www.alkalizeforhealth.net/Lenzymes.htm_

(http://www.alkalizeforhealth.net/Lenzymes.htm)

 

 

This email was sent to me by Ellen Rhudy in regards to Wobenzym and the

importance of systemic adjunct enzyme therapy during any treatment for

cancer--conventional or non-toxic. Thought you might find some of this material

interesting and possibly helpful.

 

Peter Lorenz

 

 

Tue, 23 Oct 2001 20:25:38 -0400

" R. Rhudy " <_rhudy_ (rhudy) >

_asidfsc_ (asidfsc) ,

_ldavis_ (ldavis)

Seacoast Natural Foods: Leading European Oncologist Discusses

Systemic Oral Enzyme Therapy & Cancer.

 

 

_http://www.wobenzymonline.com/_ (http://www.wobenzymonline.com/)

All information presented is for education and research and is not

intended to diagnose or prescribe treatment. Order Wobenzym N Here

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_www.mucos.cz_ (http://www.mucos.cz/) Evolution of a Mainstream Doctor From

Sceptic to True Believer How Systemic Oral Enzymes Help Clinical

Observations The Doctor's Prescription Leading European Oncologist Discusses

Systemic Oral Enzyme Therapy & Cancer by Dr. Heinrich Wrba from The Doctor's

Prescription for Healthy Living - Volume 4, Number 4

 

 

Even now in his mid-eighties when he maintains great health and an active

lifestyle, Dr. Heinrich Wrba remembers back to another time.

 

 

He was forty. It was after the war. One of his children - a daughter,

Michaela Siedon - was stricken with leukemia. For two years she fought the

disease, but nothing could help, and the treatments themselves were painful and

debilitating to the child.

 

 

When we met for this interview he stated bluntly, **Chemotherapy killed

her.**

This from one of Europe's leading oncologists.

 

 

To lose a child . . .

 

 

Today with some 200 publications in prestigious medical journals, Dr. Wrba

has quietly and permanently changed the way cancer is treated throughout

Europe. He has educated a generation of European oncologists on the value of

systemic oral enzymes in the treatment of cancer. It hasn't been easy. And

it hasn't always been smooth sailing. As in America, overcoming widespread

negative mythologies has been one of the greatest roadblocks. But amazing

things are happening on both continents - suddenly the concept of protease

therapy as an important aspect of cancer treatment is catching on in a major

way.

 

 

In America, the National Cancer Institute is funding a large-scale study

on the value of oral enzymes in cancer treatment (see our report in volume

4.3: 10-11, 18), and the Food and Drug Administration has awarded

investigational new drug status to a systemic oral enzyme formula. Major

advances in

cancer therapeutics with enzyme preparations have been made in Europe as

well.

 

 

Evolution of a Mainstream Doctor

 

It was some years after the death of his daughter when Dr. Wrba was head

of the federally sanctioned Cancer Research Institute in Vienna that he met

Dr. Karl Ransberger, a molecular biologist with a doctorate from Fordham

University and one of the co-developers with Dr. Max Wolf of modern systemic

oral enzyme therapy.

 

 

**Dr. Ransberger told me about systemic oral enzyme therapy, but,

naturally, being from the academic world, I responded with the 'school opinion'

that enzymes were large macromolecules that could not be absorbed from the

gut. We had all learned that, once ingested, proteins are degraded into amino

acids. That was my first objection - and that was the end of the story as

far as I was concerned.**

 

 

Still, Dr. Ransberger persisted. He insisted Dr. Wrba take a package of

the systemic oral enzyme preparation. " It was not long after that I was in a

hunting party and having lunch. A servant woman, knowing I was a doctor,

came up to me, hobbling, using a cane. She told me how she suffered terribly

from arthritis and could hardly walk or perform her duties. I didn't know

what to do for her. Out of desperation, I gave her the systemic oral

enzymes. . . . A few weeks later when I returned, she was doing much better. I

was

impressed. "

 

 

That was when Dr. Wrba contacted Drs. Ransberger and Wolf to learn more

about their research into systemic oral enzyme therapy. He quickly came to

realize two important facts about oral systemic enzyme therapy:

 

 

-- When designed properly, oral enzymes are actually absorbed into the

bloodstream where they are then able to act systemically. This process is

called resorption.

-- Systemic oral enzymes are effective in so many different conditions and

types of disease states this leads to disbelief among medical

professionals and lay persons alike that they can be of help.

 

 

This was especially true in the use of enzymes and cancer. **Progress,**

says Dr. Wrba, **came much more quickly in all other fields such as vascular

disease, rheumatology and hematology - but not for cancer therapeutics.

The thinking among oncologists was and has been for so long that a 'drug' or,

in this case, a natural medicine, without side effects cannot have

beneficial effects. It is the age old concept that a substance must have some

poisonous qualities to be of benefit. It took such a long time for a

breakthrough.**

 

 

From Sceptic to True Believer

 

In 1965, Dr. Wrba was invited to become Chair of Oncology at the

University of Vienna. Throughout his professional work, he has carried the

message

of oral systemic enzyme therapy to his colleagues.

 

 

What Dr. Wrba has seen in treating more than one-thousand patients and

overseeing countless other cases has convinced him of the utility of systemic

oral enzyme therapy in cancer therapeutics.

 

 

In Germany, systemic oral enzymes are not officially accepted for cancer

therapeutics, says Dr. Wrba, yet, in practice, " almost every patient gets

them. "

 

 

How Systemic Oral Enzymes Help

 

Dr. Wrba explained how systemic oral enzymes help in the prevention of

cancer and in cancer therapeutics. Cancerous or diseased cells are a fact of

life, but most of these cells are quickly destroyed by the body's contingent

of white blood cells which form the firewall of the immune system. Other

cancerous cells wander aimlessly about via the blood stream but are so few

in number and unable to attach to any tissues that they ultimately die off.

 

 

But under detrimental influences such as environmental pollution, tobacco

smoke, sunburn, radiation, and environmentally weakened or age-related

lapses in immunity, the balance between friend and foe is disrupted. The body

is no longer capable of suppressing the cancer cells. When a significant

number of cells escape destruction, their capabilities change. Some are

capable of adhering to cell walls and begin their " dirty tricks " campaign.

Almost

seemingly capable of sensing that the body's immune defenders might

recognize them, the cancer cells hide themselves under a thick coat of adhesive

fibrin, a coat that is some fifteen times more thick than the fibrin over

normal cells. The thickened coat hides away their suspicious markings,

including their antigens, from the body's immune defenders. The cancer cells

with

their sticky coating can adhere to tissues where they congregate and

multiply. To throw the body's immune cells further off track, the cancerous

cells may slough off their antigens. The immune cells immediately attack these

harmless proteins but leave the cancerous cells unharmed. It is a type of

warfare that could make a military general envious.

 

 

The cancer cells grow because of the absence or inadequate presence of

enzymes that are capable of striping the fibrin away from the individual

cancer cells. Adequate enzyme activity can lay bare their antigens and so pave

the way for their destruction by the body's immune cells. The more cancer

cells the body produces, the more enzymes that are required.

 

 

At the Austrian Cancer Research Institute at the University of Vienna, Dr.

Wrba and his researchers have long been studying the role that systemic

oral enzymes play in disrupting cancerous processes. Working with Dr. Lucia

Desser, the team discovered that treating cells with enzyme mixtures caused

substantial secretions of a chemical called tumor necrosis factor. Tumor

necrosis factor or TNF is secreted by immune cells and is capable of

attacking cancer cells and those cells infected with viruses. It is vital to

our

body's cancer defenses.

 

 

In general, enzymes are used as complementary therapy in combination with

other modes of treatment. Clinical data support their efficacious use in

brain tumors; epithelial tumors in the region of the head and neck; lung

cancer; malignant melanoma; leukemia; T cell lymphomas; stomach and colon

cancer; cancerous diseases of the abdomen; pancreatic cancer; and tumors of the

cervix, breast and uterus. The benefits extend to life prolongation,

quality of life, and improvement in cancer markers.

 

 

Dr. Wrba notes that Paul Ehrlich (1854-1915), a famous German physician

and scientist, had already established a theory at the beginning of the

century that the development of cancer is dependent on the results of the

**fight** between the tumor cells and the immunological system. " The strength of

the immunological system and the particular characteristics of the tumor

cells are responsible for the outcome of this conflict, " notes Dr. Wrba.

**These characteristics include the malignancy of the tumor or its tendency to

metastasize and to penetrate into other tissues, as well as its capability

of disguising itself from the immune cells. The recognition of tumor cells

by the immunological system is a very difficult procedure. It should not be

forgotten that tumor cells differ only insignificantly from healthy cells -

a cause for problems with the defensive system. In spite of these

difficulties, and according to the knowledge presently available, the healthy

immunological system is nonetheless able to recognize and to destroy the great

majority of tumor cells.**

 

 

**As a logical consequence, there are two modes of therapy for the

immunological treatment of cancer,** continues the doctor. **Attempts are made

both to increase the recognizability of the tumor cells for the immunological

system (that is, their immunogenicity) as well as to strengthen and

stimulate the various parts of the immunological system. Proteolytic enzymes

are

able to play a role in both aspects of this therapeutic strategy. They

increase immunogenicity of the tumor cells and, at the same time, support the

immunological system of patients at various levels.**

 

 

Clinical Observations

 

**Using 20 to 30 tablets twice daily [of Wobenzym N or similar Mucos

Pharma GmbH enzyme mixtures], we see improvement,** Dr. Wrba says. **I have

seen

about one-third of cases of pancreatic cancer that were completely cured

with about two-thirds not responding well, which for this cancer is an

excellent outcome. Based on experience, the outcome for most patients is

improved with systemic oral enzyme therapy. Enzymes rank as my favorite

adjuvant

medicine for every type of cancer. It is very essential to take them in very

high doses. We can force a beneficial effect at 30 pills three times

daily.**

 

 

Today, in Europe, although enzymes are not necessarily officially part of

cancer treatment protocols, Dr. Wrba estimates that about 90 percent of c

ancer patients are given them or told to take them unofficially. What

happened many years ago to his Michaela Siedon could never be changed. But what

Dr. Wrba has accomplished since them has changed the course of survival for

so many cancer patients.

 

 

The Doctor*s Prescription

 

Everyday Dr. Wrba takes 15 to 20 Wobenzym N tablets to help reduce his

risk for cancer and to take advantage of their overall healthful properties.

He advises anyone interested in reducing their cancer risk or in fighting

premature aging to use Wobenzym N systemic oral enzymes, which are available

at health food stores and natural product supermarkets nationwide.

 

 

In cancer treatment, work with your doctor, he advises. Dosages of up to

30 pills three times daily may be necessary.

 

 

References

 

Wrba, H. & Pecher, O. Enzymes: A Drug of the Future. Ecomed

Verlagsgesellschaft AG & Co., 1993

 

***

 

The following is reprinted from _www.apricotsfromgod.com_

(http://www.apricotsfromgod.com/) . The Apricots From God website was removed

from the

Internet under court order in the United States apparently because they were

selling apricot seeds. However, you can often find remnants of old web sites

at _www.archive.org_ (http://www.archive.org/) which is where we found

this article.

 

 

ENZYMES

 

(In short, Enzymes digest the cancer cell wall so that other things can

get in and kill the rest of the cell. Dr. Kelly has an enzyme therapy that is

expensive but digests the tumor in four weeks.)

 

 

 

The Keys to Life

 

 

These powerfully active natural chemicals are protein-mineral complexes

which occur in all living things and make possible virtually all of the many

biochemical reactions in the body. They are indispensable to life and to

good health.

 

 

Whenever there is a significant reduction in the presence or the

availability of enzymes, sickness and degeneration begin.

 

 

These keys to life can be roughly divided into three types: those derived

from food, digestive enzymes, and metabolic enzymes.

 

 

Food enzymes are abundantly present in all uncooked vegetables, fruits,

and grains. They assist in the breakdown of the food in which they are

present and also perform other useful functions in the body. Food processing

commonly employed today destroys nearly all of the enzymes normally present in

foods. Whatever enzymes may remain after processing at the factory are

finished off at home on the range.

 

 

Cooking by whatever means, except for very light steaming, will completely

destroy all enzymes in food - even the foods that were healthy to start

with.

 

 

Destroying the enzymes in food places an extra burden on the second group,

the digestive enzymes. These are normally made by the pancreas, which

produces a specific digestive enzyme for the breakdown and assimilation of each

type of food we consume - lipase for fats, amylase for carbohydrates or

sugars, and proteases for different types of protein.

 

 

Metabolic enzymes make up the third and most abundant group of enzymes in

the body, and these function within the cell to regulate such activity as

detoxification, oxygen utilization and energy production, along with a

multitude of life-sustaining and disease fighting functions.

 

 

There are over 3000 enzyme systems at work in the body. Performing a vast

number of functions, these indispensable substances hold the keys to life.

They assist greatly in the rebuilding of all tissues in the body by

breaking down ingested protein into its component amino acids which the body

uses

as building blocks for repair and rejuvenation. They attack waste materials

in the blood and in the tissues, converting them into a form that can be

readily eliminated, thereby acting as blood purifiers.

 

 

The immune system depends heavily upon enzymes for all of its functions.

To enumerate all of the actions of enzymes in detail would take several

volumes and need not be elaborated upon in this small book. Suffice it to say

that they are essential to the performance of every function of every organ

system in our bodies.

 

 

Many white blood cells produce and utilize enzymes as a necessary part of

their function. Front-line soldiers of the white cell army, called

macrophages, discussed elsewhere in this book (see Chapter Al), are

indispensable

fighters of the cellular part of the immune system. They are the *cleanup

crew* or *sanitation department* of the body.

 

 

Literally *big eaters,* these macrophages permeate every tissue in the

body, seeking out, attacking, surrounding, ingesting, and digesting, by enzyme

activity all foreign materials—toxins from outside and inside the body,

dead or dying cells, degenerating cells, and of, course, cancer cells.

 

 

Needless to say, these warriors are absolutely essential in protecting the

body from cancer as well as in fighting cancer once it has secured a

foothold. Great care must be exercised to protect these hungry macrophages lest

toxic residues, microorganisms and abnormal cells accumulate in the

tissues, blood and Iymph, leading to degenerative disease, including cancer.

 

 

A myriad of environmental toxins, stress, poor dietary habits, drugs

(especially chemotherapeutic agents) all have inhibiting effects on these

important fighters and their enzymatic activity.(l)

 

 

Another cancer-fighter, the T-lymphocyte, more specifically the killer

T-cell, attacks cancer cells in a similar manner, utilizing enzymes in its

ability to dissolve and digest tumor cells (see Chapter VI). As we have seen

these fighters are part of a highly integrated system capable of recognizing

cancer cells, then attacking and destroying them. This information is

extensively utilized by alternative care

 

 

110 CANCER AND COMMON SENSE

 

Physicians, such as myself, in designing an effective program to combat

cancer or any disease, such as AIDS, which has immune deficiency as its

principal feature.

 

 

Other enzymes, particularly the proteolytic enzymes from the pancreas,

have the unique ability to break down the muco-protein coating which encases

all malignant tumors and protects cancer cells from attack by the body's

immune system.

 

 

Enzymes also protect the body against cancer particularly metastatic or

spreading cancer—in other ways.

 

 

Pre-cancer cells become attached to body tissues by means of fibrin, a

protein component necessary for blood clotting. Enyzmes digest away the

fibrin, preventing the attachment of pre-cancerous and cancerous cells to body

tissues, thus releasing these abnormal cells into the circulating blood where

they are normally destroyed by the fighters described above.

 

 

Research has shown that enzymes in this case, bromelain, a

protein-digesting vegetable enzyme—have the power to transform cancer cells to

normal

cells. This and other evidence seems to indicate that—in addition to their

many

other attributes—enzymes may have a directly normalizing effect on cancer

cells.(1)

 

 

Enzymes also have an activating effect on the immune system and are

believed to be an integral part of that system. Studies have shown that cancer

is

associated with severe deficiencies of many enzymes.

 

 

This knowledge is not new.

 

 

A century ago, Scottish embryologist John Beard (see Chapter Lip, in spite

of having little knowledge of enzymes, discovered that by taking pancreas

tissue from young animals he could extract a liquid which was effective in

causing tumor reduction.

 

 

Practicing in England, Dr. Beard would inject his pancreatic extract

either directly into accessible tumors or into the muscle or vein of the

patient. Even some advanced cancers considered to be incurable were made to

completely disappear. He was able to help or apparently cure over half of his

patients, most with advanced cancers, a far cry from today's dismal

statistics.(2)

 

 

His was a crude preparation, containing impurities and foreign proteins

which produced some allergic reactions. For this he was roundly criticized

and attacked by his peers in the medical profession, not unlike organized

medicine's attacks today on the innovative physician.

 

 

ENZYMES 111

 

 

His attackers tried to " put him out of business " by discrediting him,

pointing to the adverse reactions and to the patients who died despite his

treatment. This also reminds us of the prevailing bias among mainstream

physicians today—namely, that it is acceptable for a patient to die while

under

conventional treatment (or because of it), but it is definitely not tolerable

for this to happen while a patient is under alternative care.

 

 

Because there arose such a demand for Dr. Beard*s pancreatic enzyme

preparation, English physicians were hounded by their patients to be treated

with

this miraculous substance. Consequently, 8 attempts were made to duplicate

the material, pharmacists obtaining pancreatic juice from local

slaughterhouses

 

 

The trouble was, the pancreases were taken from older animals with far

less enzymatic activity than the younger animals which Beard had made sure

were the source of his material. The other factor which rendered the attempted

duplication totally ineffective was the passage of time. Enzymes have a

relatively short " shelf life, " being " live " substances and remaining active

only for a matter of hours after removal from the animal.

 

 

Beard had been careful to use only freshly removed pancreases for his

material. Thus, the obtaining of material by other physicians through " normal

channels, " i.e. slaughterhouses, pharmacists, couriers, etc., resulted in

enough delay that the enzymes were rendered completely useless.

 

 

Since Dr. Beard*s colleagues had no success with their inactive enzyme

material, the concept and method of treatment sadly fell into disrepute and

into obscurity. Fortunately, in 1907 Beard wrote a book about his experiences

in treating cancer patients and his hypothesis of the causation of cancer,

now known as the **trophoblast** theory, so his work was not completely

lost to posterity (see Chapter IV). However, for nearly 50 years there was

no significant activity in the area of enzymes and cancer, Beard's work

having been forgotten, and consensus medicine of the day having returned to its

certainty that enzymes could not have anything to do with cancer, much

less anything to do with curing it.

 

 

Next on the enzyme scene was Dr. Max Wolf, a professor at Columbia

University, New York. Dr. Wolf had developed an interest in enzymes and cancer

and

had written to all of the medical libraries in the US and much of the

Western world seeking information on the subject.

 

 

112 CANCER AND COMMON SENSE

 

Reading virtually everything that had ever been written about the subject

up to that time, Wolf became probably the world's leading authority on

enzymes and their relationship to cancer. One of the books he managed to locate

and read was John Beard's book, of which there were then precious few

remaining.

 

 

Working at his research laboratory at Columbia in the 1950s, Wolf designed

a complicated and extensive study of the effect of enzymes on cancer

cells.(4,5) Thousands of cell cultures were prepared with normal cells and

cancer cells living and growing together. Each of these cultures was then

treated with a particular enzyme or combination of enzymes to determine which

was

most effective in killing cancer cells while preserving normal ones.

 

 

A wide range of enzymes and combinations was tested in this way to

establish the most potent combination which would safely avoid damaging normal

cells. Because of Wolf*s connections in Germany (and because of the inhibiting

presence of the American FDA), clinical work was carried out in that

country using the final formula on human cancer victims with highly favorable

results.

 

 

This particular mixture of enzymes survives to this day as Wobe-Mugos—the

*Wobe* part being derived from the names Wolf and Benitez (Wolf*s partner

in all of this work)—which has been used to treat tens of thousands of

cancer patients in Germany over approximately the last 30 years. This material,

along with a companion product called Wobenzyme, has also been used in the

US by a few physicians, including myself, as well as in several Mexican

clinics.

 

 

Also available from Germany is an injectable preparation of Wobe-Mugos

enzymes, which I have found quite useful in treating accumulations of fluid in

the chest, called pleural effusions, when these accumulations are due to

cancer. This has been done in Germany for many years with consistent success.

Collections of abdominal fluid, called ascites, can be treated in like

manner. In addition, any tumor which is accessible by needle may be treated

with this material.

 

 

These and other similar enzyme products have a wide application in

medicine, being effective against many inflammatory conditions—arthritis,

autoimmune diseases, injuries, blood clots, and phlebitis, to name a few—as

well as

against cancer.

 

 

I consider enzymes to be indispensable in the management and control of

cancer. If I were to be limited to a single nutritional substance in this

management, it would probably be enzymes.

 

 

ENZYMES 113

 

To illustrate the importance of enzymes and to show why their decrease or

disturbance represents such a prevalent problem in Western society, I would

indulge the reader in a brief lesson in anatomy and physiology.

 

 

Herbivorous animals (non-cheating vegetarians) have an extra pouch above

the stomach which has the purpose of carrying out predigestion. As we have

seen, raw plant foods contain their own enzymes, and the pre-stomach sac in

the animal allows the food to be pre-digested by its own enzymes, along with

enzymes in the saliva, before passing on to gastric or stomach digestion.

(See figure A next page.)

 

 

Not well known is the fact that humans have similar equipment for

two-stage digestion. Dr. Edward Howell, among others, has done research

demonstrating that the human stomach is, physiologically, actually two stomachs,

each

performing a distinctly separate function. The upper stomach, called the

cardiac portion (because of its location beneath the heart, not because it has

anything directly to do with the heart), acts as a " storage bag, " with

none of the peristaltic action (churning) such as that which is present

throughout the remainder of the digestive tract.

 

 

This portion of the stomach has few if any, of the glands that secrete

hydrochloric acid and enzymes so prevalent in the lower portion of the

stomach. This relatively inert bag at the human stomach's upper end corresponds

to

what Howell calls the food enzyme stomach in animals, the purpose of which

is to allow enzyme containing foods and salivary enzymes to pre-digest

food, preparing it for gastric digestion.(3)

 

 

By eating enzyme-poor foods, cooking or processing out what few enzymes

remain in food, then eating too much of this, it is easy to see that we of

the Western world have under-used our enzyme-food stomachs and placed an

extra burden on the remainder of the digestive apparatus.

 

 

In the lower or pyloric portion of the stomach, food is more actively

broken down by hydrochloric acid, pepsin, and other gastric enzymes. This part

of the stomach has very active peristaltic movement in contrast with the

relatively quiescent upper part.

 

 

Now overburdened by inadequately digested food, the pyloric stomach then

passes this burden on to the duodenum or first part of the small intestine,

where enzymes from the pancreas try to deal with the bad hand they have

been dealt.

 

 

Unwholesome meal after unwholesome meal, year after year, takes a profound

toll on the enzyme " pool, " the total enzymes available in the intestinal

tract and elsewhere. Like being repeatedly overdrawn at the bank eventually

something bad happens. Not only bad dietary habits but aging further

depletes our store of enzymes, contributing to the perpetual withdrawal

problem.

It is thus exceedingly important to keep putting " money in the bank " in

the form of food enzymes from uncooked vegetables, fruits, grains, sprouts,

digestive enzymes and food enzyme supplements. And this includes

supplements to help compensate for the body's store of decreased or missing

" antioxidant " enzymes (see Chapter m), which also have a role to play in

cancer.

Studies have shown that in patients with pancreatic cancer and post-surgical

breast cancer treated with enzymes, survival rates were significantly

better than for those not treated with enzymes.(6) It is my carefully

considered opinion that a chronic deficiency of total enzymes available to the

body

is a major factor contributing to the development of cancer and other

degenerative diseases, and that enzymes from both animal and vegetable sources

have a definite place in the management and treatment of the cancer patient.

 

 

 

REFERENCES

 

1. Maurer, H. et al., " Bromelain induces the differentiation of Ieukemia

cells in vitro: an explanation for its cytostatic effects? " Planta Med.

377-81, 1986.

 

2. Beard, J., Enzyme Therapy of Cancer. In Vienna: Maudrich-Verlag, 1971.

Wolt; M. (Hrsg),

 

3. Howell, E., Enzyme Nutrition— The Food Enzyme Concept. Wayne NJ: Avery

Publishing, 1985.

 

4. Wolf, M.; Ransberger, K., Enzyme Therapy. Vienna, MaudrichVerlag, 1970.

 

5. Lopez, D., et al., Enzymes—The Fountain of Life. Neville Press, 1994.

 

6. Boit, J., " Digestive Enzymes. " in: Cancer and Natural Medicine: A

Textbook of Basic Science and Clinical Research, pp 165-6. Princeton, MN:

Oregon

Medical Press,