Herb Of The Week - Sage - Alzheimer's Research

[Guest guest]

Passing along an abstract from a study done to determine salvia

officinalis'

effectiveness in treating Alzheimer's disease

 

*Smile*

Chris (list mom)

 

http://www.alittleolfactory.com

 

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

http://www.blackwell-synergy.com/openurl?genre=article

<http://www.blackwell-synergy.com/openurl?genre=article & sid=nlm:pubmed & i

ssn=0269-4727 & date=2003 & volume=28 & issue=1 & spage=53>

& sid=nlm:pubmed & issn=0269-4727 & date=2003 & volume=28 & issue=1 & spage=53

 

Salvia officinalis extract in the treatment of patients with mild to

moderate Alzheimer's disease: a double blind, randomized and

placebo-controlled trial.

 

Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani

M.

 

Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences and

Institute of Medicinal Plants, Iranian Academic Centre for Education,

Culture and Research, Tehran, Iran. s.sakhond

 

 

Abstract

 

 

 

_____

 

Journal of Clinical Pharmacy & Therapeutics

Volume 28 Issue 1 Page 53 - February 2003

doi:10.1046/j.1365-2710.2003.00463.x

 

 

 

Salvia officinalis extract in the treatment of patients with mild to

moderate Alzheimer's disease: a double blind, randomized and

placebo-controlled trial

S. Akhondzadeh*

<javascript:popup('citart1','a1%20a2','10.1046/j.1365-2710.2003.00463.x'

,'aj13652710200300463x','')> +PhD, M. Noroozian*

<javascript:popup('citart1','a1','10.1046/j.1365-2710.2003.00463.x','aj1

3652710200300463x','')> MD, M. Mohammadi*

<javascript:popup('citart1','a1','10.1046/j.1365-2710.2003.00463.x','aj1

3652710200300463x','')> MD, S. Ohadinia

<javascript:popup('citart1','a2','10.1046/j.1365-2710.2003.00463.x','aj1

3652710200300463x','')> +MD, A. H. Jamshidi

<javascript:popup('citart1','a2','10.1046/j.1365-2710.2003.00463.x','aj1

3652710200300463x','')> +PharmD and M. Khani

<javascript:popup('citart1','a2','10.1046/j.1365-2710.2003.00463.x','aj1

3652710200300463x','')> +MSc

 

Summary

 

Background: Alzheimer's disease is characterized by a slow, progressive

decline in cognitive function and behaviour. Acetylcholine esterase

inhibitors are the only agents approved by the Food and Drug

Administration for the treatment of Alzheimer's disease. All other

agents prescribed for the treatment of Alzheimer's disease are used on

an off-label basis. Current research into new drugs is focused on agents

that will prevent, slow down and/or halt the progress of the disease

process. Savia officinalis has been used in herbal medicine for many

centuries. It has been suggested, on the basis of traditional medicine,

its in vitro cholinergic binding properties and modulation of mood and

cognitive performance in humans, that Salvia officinalis might

potentially provide a novel natural treatment for Alzheimer's disease.

The objective of this study was to assess the efficacy and safety of

Salvia officinalis extract using a fixed dose (60 drops/day), in

patients with mild to moderate Alzheimer's disease, over a 4-month

period.

 

Methods: This was a 4-month, parallel group, placebo-controlled trial

undertaken in three centres in Tehran, Iran. Patients with mild to

moderate Alzheimer's disease aged between 65 and 80 years (n = 42, 18

women) with a score of = "

src= " http://www.blackwell-synergy.com/na102/home/ACS/blackwell/journals/

entities/2265.gif " align=absBottom border=0>12 on the cognitive subscale

of Alzheimer's Disease Assessment Scale (ADAS-cog) and <=

<http://www.blackwell-synergy.com/na102/home/ACS/blackwell/journals/enti

ties/2264.gif> 2 on the Clinical Dementia Rating (CDR) were randomized

to placebo or fixed dose of S. officinalis extract. Over the 16 weeks,

the main efficacy measures were the change in the ADAS-cog and CDR-Sum

of Boxes scores compared with baseline. In addition, side-effects were

systematically recorded throughout the study using a checklist.

 

Results: At 4 months, S. officinalis extract produced a significant

better outcome on cognitive functions than placebo (ADAS-cog: F = 4.77,

d.f. = 1, P = 0.03) (CDR-SB: F = 10.84, d.f. = 1, P < 0.003). There were

no significant differences in the two groups in terms of observed

side-effects except agitation that appears to be more frequent in the

placebo group (P = 0.09).

 

Conclusions: The results of this study indicate the efficacy of S.

officinalis extract in the management of mild to moderate Alzheimer's

disease. Moreover, S. officinalis may well reduce agitation of patients

but this needs to be confirmed.

 

 

 

 

 

[Guest guest]

Chris:

 

A while back one of the members listed a sale approved by you, but I cannot find

her site. She had the gold bottles on sale along with some other items. My

mind has drawn a blank and I thought I'd saved her under your files, but have

searched them and cannot find it. If this rings a bell for you or anyone, I'd

appreciate any assistance you can provide. I need some jars and wanted to check

her site. Is anyone having a sale on them? Thanks in advance.

 

Hope each of you are doing okay. Wishing the best for all of you in 2005.

 

Blessings,

Debbie

Alabama