Drugs and acupuncture interaction

[Guest guest]

Dear friends on the list,

 

Since there is a great chance of Acupuncture Drug

interaction I have decided to make a list of them for

general use, I know 4 drugs till know and I will be

happy if you can add to the list.

Naloxone

Propranolol

Cortisol

Prednisolone

 

I know acupuncture reacts with thyroxin as well but

could not find any references yet .But I have seen the

reaction in the patients taking thyroxin.

 

Hope you help to complete the list.( please mention

the references if you can )

regards

DR,Fadaie

 

 

 

 

 

 

 

 

 

[Guest guest]

Hi!

 

What sort of interactions are you thinking about? Acupuncture (TuiNa,

Shiatsu) do help with many of our client's problems. So their medication

levels may need to be re-adjusted, or at least get monitored more closely.

 

Artemis

 

 

----- Dear friends on the list,

 

Since there is a great chance of Acupuncture Drug

interaction I have decided to make a list of them for

general use, I know 4 drugs till know and I will be

happy if you can add to the list.

[Guest guest]

Could you share more about this? I have to admit I've never heard of an

interaction between drugs and acupuncture, nor can I figure out how that would

work. I've treated people taking some of those drugs and haven't seen any

untoward effects. I'd be grateful for any more information that you can share.

Thanks, Liz

 

 

-

majid fadaie

Chinese Medicine

Friday, September 08, 2006 4:58 AM

Drugs and acupuncture interaction

 

 

Dear friends on the list,

 

Since there is a great chance of Acupuncture Drug

interaction I have decided to make a list of them for

general use, I know 4 drugs till know and I will be

happy if you can add to the list.

Naloxone

Propranolol

Cortisol

Prednisolone

 

I know acupuncture reacts with thyroxin as well but

could not find any references yet .But I have seen the

reaction in the patients taking thyroxin.

 

Hope you help to complete the list.( please mention

the references if you can )

regards

DR,Fadaie

 

 

 

 

 

 

 

[Guest guest]

Hi,

 

Can you describe the reactions to thyroxin?

 

Pat

 

________________________________

 

Chinese Medicine

Chinese Medicine On Behalf Of majid

fadaie

Friday, September 08, 2006 4:58 AM

Chinese Medicine

Drugs and acupuncture interaction

 

 

 

Dear friends on the list,

 

Since there is a great chance of Acupuncture Drug

interaction I have decided to make a list of them for

general use, I know 4 drugs till know and I will be

happy if you can add to the list.

Naloxone

Propranolol

Cortisol

Prednisolone

 

I know acupuncture reacts with thyroxin as well but

could not find any references yet .But I have seen the

reaction in the patients taking thyroxin.

 

Hope you help to complete the list.( please mention

the references if you can )

regards

DR,Fadaie

 

 

 

 

<>

 

 

 

 

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[Guest guest]

Steroids block the action of acupuncture is what I am told and is

consistent with my experience. A list with interactions and what the

action might be would be helpful. Also, as a NADA trainer, I was

informed by Mike Smith that those taking anxiolytics (anti anxiety

medications) at higher doses than are medically warranted (meaning

the appropriate dose for anxiety), one can get an effect with

acupuncture, but if they are taking higher doses than medically

warranted in order to get high, no effect will be noted from

acupuncture.

 

Laura cooley

[Guest guest]

I'd like to see the research, any citations?

 

Avery

 

 

On Fri, 08 Sep 2006 15:03:25 -0400, Laura Cooley <lauracooley

wrote:

 

> Steroids block the action of acupuncture is what I am told and is

> consistent with my experience. A list with interactions and what the

> action might be would be helpful. Also, as a NADA trainer, I was

> informed by Mike Smith that those taking anxiolytics (anti anxiety

> medications) at higher doses than are medically warranted (meaning

> the appropriate dose for anxiety), one can get an effect with

> acupuncture, but if they are taking higher doses than medically

> warranted in order to get high, no effect will be noted from

> acupuncture.

>

> Laura cooley

 

 

 

--

Using Opera's revolutionary e-mail client: http://www.opera.com/mail/

[Guest guest]

Avery, Majid, Laura,

Some good points all around, and also some need for caution with

statements. Majid, you are describing your individual experience

with medications and acupuncture/moxa. I find that all steroids, in

large doses, can lessen the beneficial therapeutic effects of

acupuncture, but that small, long-term doses are less of a problem.

In fact, I manage patients on long-term steroids very well with

acupuncture and herbs, and in mainland China, it I have no experience

with naloxone patients, but what you say sounds reasonable. However,

this is our personal experience, and even though valuable, we need to

gather others' experiences in order to confirm our own.

 

I think we need to somehow, as a profession, find a way to

catalog our experiences with drugs, herbs and acupuncture

interactions in some kind of data base, otherwise, there tend to be

overreactions to observations like the ones discussed here. In other

words, statements get taken out of context, and rumors spread. For

example, in Israel, there was a gentleman teaching acupuncture who

taught that using more than three needles in a treatment, or

repeating points in further treatment 'damaged the points'. A lot of

students were misled and confused by such statements. Also in

Israel, another dogma that cancer patients shouldn't be treated by

acupuncture. A lot of patients may have missed out on the benefits

of acupuncture from this. There are dogmas about drug-herb

interactions that have become accepted, such as not treating any

patients with herbs or acupuncture who are undergoing chemotherapy,

or who are on coumadin, despite evidence to the contrary. Combining

chemotherapy and radiation with acupuncture and herbal medicine, for

example, is standard practice in China, and many papers are available

on the subject. Of course, there are situations where we should be

cautious or abstain, but each clinical encounter has to weigh all

factors and information together carefully.

 

All in all, we are in new territory here.

 

 

On Sep 8, 2006, at 3:07 PM, Dr. Avery Jenkins wrote:

 

> I'd like to see the research, any citations?

>

> Avery

 

 

On Sep 8, 2006, at 1:58 AM, majid fadaie wrote:

 

 

> Dear friends on the list,

>

> Since there is a great chance of Acupuncture Drug

> interaction I have decided to make a list of them for

> general use, I know 4 drugs till know and I will be

> happy if you can add to the list.

> Naloxone

> Propranolol

> Cortisol

> Prednisolone

>

> I know acupuncture reacts with thyroxin as well but

> could not find any references yet .But I have seen the

> reaction in the patients taking thyroxin

 

 

 

[Guest guest]

Dear All>

Drugs may

1. enhance

2. reduce

3. have no interaction

with acupuncture .

followings are examples from the personal experiences

followed with some abstracts form Medline showing

that acupuncture reacts with drug metabolism .

1. Hypothyroids taking thyroxin, I have seen they may

experience sever anxiety like reactions ( personal

observation in 2 patients)

2. Propranolol may feel palpitations and lethargy .

(Observation in two patients in addition to abstracts

 

 

Dr.Fadaie

SOME ABSTRACT REGARDING DRUGE AND ACUP INTERACTION

 

 

1. Lundeberg T, Eriksson SV, and Theodorsson E.

Neuroimmunomodulatory effects of acupuncture in mice.

Neurosci.Lett. 1991; 128: 161-4.

Abstract: The purpose of this study was to assess the

effect of acupuncture on the immunological response.

The induction of anti-sheep red blood cells (SRBC)

plaque-forming cells (PFC) was used as a measurement

of the immune response to treatment. In normal

non-immunized mice, enhancement of PFC was seen after

a single acupuncture treatment when spleen cells from

stimulated mice were cultured with SRBC in vitro.

After 3 acupuncture treatments, spleen cells from mice

did not show PFC enhancement after treatment with

anti-Thy-1.2 antibody and complement, nor after the

removal of non-adherent cells. Serum obtained from

mice 1 h after acupuncture stimulation enhanced the

PFC of normal spleen cells in vitro, but the

enhancement was abolished by the addition of

propranolol. These results suggest that acupuncture,

by activation of the autonomic nervous system,

modulates the immune response

2. Nezhentsev MV and Aleksandrov SI. [Febrifugal

activity of acupuncture and its strengthening by the

effects of anaprilin]. Biull.Eksp.Biol.Med. 1992; 113:

288-90.

Abstract: The power and duration of antipyretic

actions of acupuncture under single or repeated

stimulation of Shaoshang (Lu-11) and Shangyang (LI-1)

acupoints were studied in rabbits. Under conditions of

preliminary i. v. injection of propranolol (1-2

mg/kg), strengthening of acupuncture antipyretic

activity was revealed. This effect suggests

participation of norepinephrine system in mechanism of

febrifugal action of acupuncture

3. Nishijo K, Mori H, Yosikawa K, and Yazawa K.

Decreased heart rate by acupuncture stimulation in

humans via facilitation of cardiac vagal activity and

suppression of cardiac sympathetic nerve.

Neurosci.Lett. 1997; 227: 165-8.

Abstract: The effect of acupuncture stimulation

applied to a Ximen point (P4) of a forearm on heart

rate was studied in healthy volunteer human subjects.

Acupuncture stimulation decreased heart rate, or gave

no significant response. The decreased response of

heart rate following acupuncture was attenuated by

administration of atropine and propranolol. Therefore,

the acupuncture-induced response of decrease in heart

rate was concluded to be a result of a reciprocal

coordination of an increase in cardiac vagal activity

and a decrease in cardiac sympathetic activity

4. Zou CJ, Wang H, and Ge L. The central mechanism

of the depressor-bradycardia effect of " Tinggong.

Acupunct.Electrother.Res. 2000; 25: 145-53.

Abstract: Roles of central adrenergic receptors and

opioid receptors in the depressor-bradycardia effect

of 3V, 2Hz " Tinggong-Quchi " electroacupuncture (the

EA-DpB, i.e.the depressor bradycardia induced by

electroacupuncture) were studied by

intracerebroventricula (icv) injection of prazosin,

yohimbine or propanol, naloxone or by intra-arachnoid

(ith) injection of naloxone. Voltage-dependent

depressor effects were induced by 2Hz " Tinggong-Quchi "

acupuncture. The depressor effect of 3V, 2Hz "

Tinggong-Quchi " acupuncture was attenuated by icv

injection of a beta-receptor antagonist-propranolol,

but was not blocked by the icv injection of an alpha1

-or (alpha2 -receptor antagonist prazosin or

yohimbine. Icv injected naloxone but not ith injected

naloxone blocked or reversed the EA-DpB. Results

suggest that central P-receptors or opioid receptors

in the brain are selectively involved in the EA-DpB

5. Wang HH and Xu SF. [Effect of D1 and D2 dopamine

receptor antagonists on acupuncture analgesia]. Sheng

Li Xue.Bao. 1993; 45: 61-8.

Abstract: Some highly selective D1 or D2 receptor

antagonists were tested on rabbit skin pain model to

investigate the effect of the subtypes of dopamine

receptor on acupuncture analgesia. It was found that

iv. of D2 receptor antagonists haloperidol and

clozapine, had a potentiating effect on acupuncture

analgesia. Icv. of D2 receptor antagonists domperidone

and sulpiride and D1 receptor antagonist SCH23390 also

enhanced acupuncture analgesia markedly. The effect of

D1 and D2 receptor on acupuncture analgesia was

discussed

6. Kubota K, Matsuoka Y, Sakuma M, Satoh S, Uruno T,

and Sunagane N. Characteristic of analgesia induced by

noncatecholic phenylethylamines in mice. Life Sci.

1982; 31: 1221-4.

Abstract: Using hot plate method, analgesia induced by

noncatecholic phenylethylamines, phenethylamine,

phenylethanolamine and amphetamine, was inhibited by

naloxone, reserpine, apomorphine and

p-chlorophenylalanine, while potentiated by

haloperidol. These results suggest that

phenylethylamines induced analgesia involves central

dopaminergic and serotonergic neurons and endogenous

opioid peptides. The blockade of dopaminergic neurons

enhanced and the inhibition of serotonergic neuron

activity or the stimulation of dopaminergic neurons

attenuated the phenylethylamines induced analgesia.

Using rat hind paw pressing or tail flick test,

analgesia induced by electroacupuncture in which Hoku

points were electrically stimulated through stainless

steel needles was enhanced by phenylethylamines,

haloperidol while attenuated by naloxone, reserpine,

apomorphine and p-chlorophenylalanine. Thus the

analgegic characteristic of phenylethylamines closely

resembles that of electroacupuncture

7. Bing Z, Villanueva L, and Le BD. Acupuncture and

diffuse noxious inhibitory controls:

naloxone-reversible depression of activities of

trigeminal convergent neurons. Neuroscience 1990; 37:

809-18.

Abstract: Recordings were made from convergent neurons

in trigeminal nucleus caudalis of the rat. These

neurons could be activated by both innocuous and

noxious mechanical stimuli applied to their excitatory

receptive fields on the ipsilateral part of the

muzzle. Percutaneous application of suprathreshold, 2

ms square-wave electrical stimuli to the centre of the

excitatory field resulted in responses to A- and

C-fibres being observed. The effects on these

responses of manual acupuncture performed by a

traditional Chinese acupuncturist at the " Zusanli "

point on the right hindlimb were compared with the

effects induced by acupuncture applied at a

non-acupoint, next to " Zusanli " . In addition, the

effects of acupuncture were compared with the

inhibitory effects evoked by noxious thermal

stimulation of the left hindlimb on the responses of

the same neurons. This last type of inhibition has

been described previously by our group and termed

diffuse noxious inhibitory controls. Acupuncture,

either applied at " Zusanli " or at a non-acupoint and

noxious thermal stimulation induced similar strong

inhibitory effects on the C-fibre-evoked responses of

trigeminal convergent neurons (77.9 +/- 4.4%; 72.5 +/-

4.6% and 78.5 +/- 3.6% inhibition, respectively) and

these inhibitions were followed by long-lasting

aftereffects. In addition, both the acupuncture- and

noxious thermal stimulation-evoked inhibitions were

significantly reduced by systemic naloxone (0.4 mg/kg,

i.v.). Since the antinociceptive effects elicited by

acupuncture (i) had a similar magnitude and

time-course to those evoked by noxious thermal

stimulation, (ii) exhibited a lack of topographical

specificity and (iii) involved an opioidergic link, we

would suggest that, at least in our experimental

conditions, acupuncture manoeuvres trigger the

neuronal mechanisms involved in diffuse noxious

inhibitory controls

 

 

 

regards.

Dr.Fadaie

 

 

--- Liz <lizzzrd wrote:

 

> Could you share more about this? I have to admit

> I've never heard of an interaction between drugs and

> acupuncture, nor can I figure out how that would

> work. I've treated people taking some of those

> drugs and haven't seen any untoward effects. I'd be

> grateful for any more information that you can

> share.

> Thanks, Liz

>

>

> -

> majid fadaie

> Chinese Medicine

> Friday, September 08, 2006 4:58 AM

> Drugs and acupuncture interaction

>

>

> Dear friends on the list,

>

> Since there is a great chance of Acupuncture Drug

> interaction I have decided to make a list of them

> for

> general use, I know 4 drugs till know and I will

> be

> happy if you can add to the list.

> Naloxone

> Propranolol

> Cortisol

> Prednisolone

>

> I know acupuncture reacts with thyroxin as well

> but

> could not find any references yet .But I have seen

> the

> reaction in the patients taking thyroxin.

>

> Hope you help to complete the list.( please

> mention

> the references if you can )

> regards

> DR,Fadaie

>

>

>

> Tired of spam? Mail has the best spam

> protection around

>

>

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

 

 

 

 

 

 

[Guest guest]

I have been following this conversation with interest. I treat patients

on all kinds of medications all the time. I am setting the intention

that acupuncture can only help to align the body's energy for the good

of the patient. Once they are more settled in their bodies, they can

make the decision to wean off of medications like cortisol, anti

depressents. I treat people on thyroid meds and never expereince these

reactions. So again I would view acupuncture as a move in the healing

direction where some meds may not be needed eventually.

 

Anne

 

majid fadaie wrote:

 

> Dear All>

> Drugs may

> 1. enhance

> 2. reduce

> 3. have no interaction

> with acupuncture .

> followings are examples from the personal experiences

> followed with some abstracts form Medline showing

> that acupuncture reacts with drug metabolism .

> 1. Hypothyroids taking thyroxin, I have seen they may

> experience sever anxiety like reactions ( personal

> observation in 2 patients)

> 2. Propranolol may feel palpitations and lethargy .

> (Observation in two patients in addition to abstracts

>

> Dr.Fadaie

> SOME ABSTRACT REGARDING DRUGE AND ACUP INTERACTION

>

> 1. Lundeberg T, Eriksson SV, and Theodorsson E.

> Neuroimmunomodulatory effects of acupuncture in mice.

> Neurosci.Lett. 1991; 128: 161-4.

>

>

>

>

 

 

--

Anne C. s

===============================

 

 

 

 

[Guest guest]

Yes Zev, all well taken points. We are in new territory and I wrote

" I am told " and " my experience " , so that my comments could be put in

that context, which, as you say, can be lost in continuing

communication. In my case I learned of the steroid interference with

acupuncture from 2 unrelated physicians just as I finished an

unsuccessful course of treatments on a 62 year old woman taking

steroids for her unresolved pneumonia of 3 months. Of course, my

diagnosis and choice of tx could have been wrong, but In the past I

had treated pneumonia successfully, including long-standing pneumonia

in HIV+ persons allergic to antibiotics who relied 100% on Oriental

medicine for resolution.

 

I quote from Medical Acupuncture, A Western Scientific Approach,

edited by Jacqueline Filshie and Adrian White and published by

Churchill Livingstone, in a section on Acupuncture Analgesia, (words

in bold are mine), Pg 164: " A study by Eriksson, Lundeburg &

Lundeberg (1991) showed that diazepam (anti anxiety ) reduced the

effect of low-frequency EA (Electrical Acupuncture) on cervical

arthritis on humans; and Xu et al (1983) showed that diazepam

antagonized AA in rabbits, as did ketamine. The same authors found

that AA was potentiated in rabbits by fentanyl, pethidine,

droperidol, perphenazine, metoclopromide, fenfluramine and

tetrahydrocannabinol. Xu et al (1983) showed that metoclopramide

improved response to EA in humans undergoing thyroidectomy. "

I am not familiar with any of these studies personally, but they are

clear references to research on this topic and appear in the index

under drug interactions with electro acupuncture. Drug dose levels

are not mentioned here. And to my knowledge, electro acupuncture and

acupuncture are 2 different interventions.

 

Mike Smith informed me that he learned of the " no acupuncture effect

when taking higher than warranted dose of anxiolytics " when he made

hospital rounds to patients from his drug treatment program. These

patients previously had reported effect from the ear acupuncture

treatment. Now in the hospital, and on much higher doses of valium

than they could get within a drug treatment program having talked the

medical staff into increasing their doses of anyiolytics (a daily

request of drug addicts in treatment programs and one of the most

pressing issues for physicians in drug treatment), told Smith the ear

acupuncture had no effect. This may be anecdotal, but but it bears

keeping in mind due to the sheer numbers of people seen in that

treatment program, which hovered around 300 people a day in some years.

 

I also live with an Addictionologist (an MD who is board certified in

addictions medicine) that worked and detoxed addicts at the largest

detox center in the southwest, who recommends that one of the easiest

numbers to track on acupuncture in addiction is the lowered requests

for medication to help with withdrawals, because that is what he saw

happen.

 

Thanks to all, I would really love a comprehensive list of

interactions and acupuncture. I do not look forward to being informed

of such things by MDs. I was very surprised when I did a search on

adverse effects of acupuncture, a subject we should all be well

versed on. Laura Cooley

 

 

[Guest guest]

Hi Majid, & All,

 

This is from one of my old papers:

http://users.med.auth.gr/~karanik/english/vet/analge3.htm

Serotonin (5HT) is involved in Electro-AP analgesia and oral doses of

5HT precursors, such as d-phenyl alanine, greatly enhance AP

Analgesia and can turn " non-responders " into " responders " .

 

See also:

 

Su S, Zheng S, Su C. [Effects of four adrenergic drugs on

electroacupuncture analgesia][Article in Chinese] Zhen Ci Yan Jiu.

1992;17(3):175-8. Department of Physiology, Guangxi Medical College,

Nanning. The role of central nor-epinephrine (NE) in electroacupuncture

(EA) analgesia is a controversial question., it is probably due to the

complication of adrenergic receptors. The present results show: (1)

Clonidine 30 micrograms/2ml/kg ip had no significant effect on the pain

threshold, but decreased the analgesic effect of EA. Clonidine 1.5 and 3

micrograms were injected into the lateral cerebral ventricles. After 45

minutes, the analgesic effect of EA was lowered as compared with the

saline controls respectively. (2) Yohimbine had no significant effect on

the basal pain threshold, but (icv Yoh 50 micrograms) elevated the

analgesic effect of EA. (3) 2-adrenoceptor agonist methoxamine

decreased the analgesic effect of EA. (4) Another 2-adrenoceptor

antagonist prazosin (icv 16 micrograms) enhanced the analgesic effect

of EA. These results suggest that an activation of alpha 1- or alpha 2-

adrenoceptors would decrease the analgesic effect of EA. PMID:

1364074 [PubMed - indexed for MEDLINE]

 

Wang HH, Xu SF. [Effect of D1 and D2 dopamine receptor antagonists

on acupuncture analgesia][Article in Chinese] Sheng Li Xue Bao. 1993

Feb;45(1):61-8. Department of Neurobiology, Shanghai Medical

University. Some highly selective D1 or D2 receptor antagonists were

tested on rabbit skin pain model to investigate the effect of the subtypes

of dopamine receptor on acupuncture analgesia. It was found that iv. of

D2 receptor antagonists haloperidol and clozapine, had a potentiating

effect on acupuncture analgesia. Icv. of D2 receptor antagonists

domperidone and sulpiride and D1 receptor antagonist SCH23390 also

enhanced acupuncture analgesia markedly. The effect of D1 and D2

receptor on acupuncture analgesia was discussed. PMID: 8503031

[PubMed - indexed for MEDLINE]

 

Zhu CB, Li XY, Zhu YH, Wu GC, Xu SF. [Alteration of monoamine

contents in microdialysate following droperidol enhanced

electroacupuncture][Article in Chinese]. Sheng Li Xue Bao. 1997

Aug;49(4):382-8. State Key Laboratory of Medical Neuobiology,

Shanghai Medical University. The monoamine contents in

microdialysate from rat brain before and after droperidol (DRO), a

dopamine (DA) antagonist, enhanced electroacupuncture-induced

analgesia (EA) were measured using techniques of in vivo microdialysis

and high performance liquid chromatography with electrochemical

detection (HPLC-EC), so as to investigate the monoamine mechanism

of the potentiating effect of DRO on acupuncture analgesia (AA). The

results showed that the levels of DA and its metabolites homovanillic

acid (HVA) in perfusate increased after EA (P < 0.05 or 0.01), and

further increased after DRO + EA (P < 0.05 and 0.01, vs EA treatment).

A significant decrease in norepinephrine (NE) content after EA (P <

0.01) was observed, but no further change after DRO + EA (P > 0.05,

vs EA treatment). The contents of 5-hydroxytryptamine (5-HT) and its

metabolite 5-hydroxyindole acetic acid (5-HIAA) we elevated after EA

treatment, and a further elevation in 5-HT and 5-HIAA contents induced

by DRO + EA was noted. The results in the present study suggest that

DRO potentiated AA not only via antagonizing the activity of

dopaminergic system, but also by coordinating the activities of other

monoamines in the brain. PMID: 9812868 [PubMed - indexed for

MEDLINE]

 

Yonehara N. Influence of serotonin receptor antagonists on substance

P and serotonin release evoked by tooth pulp stimulation with electro-

acupuncture in the trigeminal nucleus cudalis of the rabbit. Neurosci

Res. 2001 May;40(1):45-51. Department of Dental Pharmacology,

Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita,

Osaka 565-0871, Japan. yonehara We studied the

effect of NAN-190 (5-HT(1A) antagonist), ketanserin (5-HT(2)

antagonist) and ICS 205-930 (5-HT(3) antagonist) on tooth pulp

stimulation (TPS)-induced 5-HT release and substance P (SP) release

in the superficial layers of the trigeminal nucleus caudalis (SpVc-I,II) in

the presence or absence of electro-acupuncture (EAP). TPS slightly

increased 5-HT release and significantly increased SP release. In

combination with EAP, TPS-induced 5-HT release was remarkably

enhanced, whereas SP release was significantly suppressed.

Pretreatment with NAN-190 (3.5 mg/kg, i.v.) significantly enhanced the

increase in TPS-induced 5-HT release in the presence of EAP. On the

other hand, the increase of 5-HT release induced following TPS in the

presence of EAP was inhibited by pretreatment with ketanserin (2.5

mg/kg, i.v.) and ICS 205-930 (1 mg/kg, i.v.). When NAN-190 was pre-

treated in the animals combined TPS and EAP, the amount of SP

release was significantly reduced compared with the absence of this

drug. On the other hand, pretreatment with ketanserin and ICS 205-930

reversed the inhibitory effect of EAP on the TPS-generated SP release,

especially ICS 205-930, which remarkably enhanced TPS-induced SP

release compared with the absence of this drug. On the basis of the

obtained results, we concluded that NAN-190 and ICS 205-930 act on

EAP-induced analgesia positively and suppressively, respectively, by

regulation of TPS-generated SP release through activation of their

subtype receptors. On the other hand, ketanserin does not affect TPS-

induced 5-HT release and SP release in the presence of EAP.

PMID: 11311404 [PubMed - indexed for MEDLINE]

 

Huang C, Long H, Shi YS, Han JS, Wan Y. Ketamine enhances the

efficacy to and delays the development of tolerance to

electroacupuncture-induced antinociception in rats. Neurosci Lett. 2005

Feb 28;375(2):138-42. Epub 2004 Nov 30. Neuroscience Research

Institute, Peking University, Key Laboratory of Neuroscience, The

Ministry of Education, 38 Xueyuan Road, Beijing 100083, China. Our

previous studies have shown that 100 Hz electroacupuncture (EA)

produced antinociception through the release of endogenous opioids

(mainly dynorphin) and the activated kappa-opioid receptors in normal

rats. Acupuncture is an effective treatment in relieving pain, but it

develops tolerance after repeated administration. It has been reported

that N-methyl-D-aspartate (NMDA) receptor antagonists could increase

the antinociceptive effects induced by morphine and delay the

development of tolerance to morphine but nothing has yet been

described to reduce EA tolerance. Here we test whether ketamine, a

non-competitive NMDA receptor antagonist, would enhance 100 Hz EA

antinociception as well as prevent or delay the development of chronic

tolerance to 100 Hz EA in normal rats. The results are as follows: (1)

ketamine injected intraperitoneally (i.p.) 15 min prior to EA enhanced

the antinociceptive effects of 100 Hz EA at a dose of 5.0 mg/kg, but not

0.2 or 1.0 mg/kg. However, ketamine at either dose did not affect the

basal nociceptive threshold (represented by tail-flick latency). (2)

Ketamine at a dose of 5.0 mg/kg delayed the development of chronic

tolerance to 100 Hz EA antinociception. We conclude that ketamine can

enhance antinociception of 100 Hz EA and delay the tolerance to 100

Hz EA in rats. These results suggest that the development of 100 Hz

EA tolerance to antinociception was mediated, at least in part, through

peripheral NMDA receptors, which may be useful in improving the

therapeutic effects of EA in the treatment of pain when EA tolerance

occurs. PMID: 15670657 [PubMed - indexed for MEDLINE]

 

Best regards,

 

HOME + WORK: 1 Esker Lawns, Lucan, Dublin, Ireland

Tel: (H): +353-(0) or (M): +353-(0)

<

 

 

 

" Man who says it can't be done should not interrupt man doing it " -

Chinese Proverb

[Guest guest]

Dear Anna

 

I do agree that acupuncture has a normalizing action,

and in long run give the best results but knowing what

drug combination may get the best results or poorer

results will help us to better follow the course of

therapy and prognosis and prevent possible negative

consequences .

Acupuncture can increase or decrease the metabolic

rates of certain drugs as it effects on the metabolism

very diversely.

 

Regards.

Dr,Fadaie

 

 

--- Anne Crowley <blazing.valley wrote:

 

> I have been following this conversation with

> interest. I treat patients

> on all kinds of medications all the time. I am

> setting the intention

> that acupuncture can only help to align the body's

> energy for the good

> of the patient. Once they are more settled in their

> bodies, they can

> make the decision to wean off of medications like

> cortisol, anti

> depressents. I treat people on thyroid meds and

> never expereince these

> reactions. So again I would view acupuncture as a

> move in the healing

> direction where some meds may not be needed

> eventually.

>

> Anne

>

> majid fadaie wrote:

>

> > Dear All>

> > Drugs may

> > 1. enhance

> > 2. reduce

> > 3. have no interaction

> > with acupuncture .

> > followings are examples from the personal

> experiences

> > followed with some abstracts form Medline showing

> > that acupuncture reacts with drug metabolism .

> > 1. Hypothyroids taking thyroxin, I have seen they

> may

> > experience sever anxiety like reactions ( personal

> > observation in 2 patients)

> > 2. Propranolol may feel palpitations and lethargy

> .

> > (Observation in two patients in addition to

> abstracts

> >

> > Dr.Fadaie

> > SOME ABSTRACT REGARDING DRUGE AND ACUP INTERACTION

> >

> > 1. Lundeberg T, Eriksson SV, and Theodorsson E.

> > Neuroimmunomodulatory effects of acupuncture in

> mice.

> > Neurosci.Lett. 1991; 128: 161-4.

> >

> >

> >

> >

>

>

> --

> Anne C. s

> ===============================

>

>

>

> [Non-text portions of this message have been

> removed]

>

>