Xiaoke Wan?

June 23, 2006

Hi Chris, & All,

> Thanks for any insights into this formula. Chris

See: http://tinyurl.com/qkv5v

.... MCA identified examples of ... a product named Xiaoke Wan which

included the oral hypoglycaemic agent glibenclamide as a listed ingredient.

Glibenclamide is restricted as a POM ingredient. Moreover, a product

containing such a non herbal ingredient could not in any case legally be sold

as an unlicensed herbal remedy. A 58 year old woman suffered

hypoglycaemic coma following the use of such a remedy.

Bailey CJ, Brown D, Smith W, Bone AJ. Xiaoke, a traditional Chinese

treatment for diabetes. Studies in streptozotocin diabetic mice and

spontaneously diabetic BB/E rats. Diabetes Res. 1987 Jan;4(1):15-8.

Xiaoke tea is consumed as a traditional herbal treatment for diabetes

mellitus in China. An aqueous extract of Xiaoke (1 g of dried plant

preparation in 64 ml of water), supplied ad lib in place of drinking water

during the induction and development of streptozotocin diabetes in mice,

reduced (about 30%) plasma glucose concentrations by 25 days. The

polydipsia and hyperphagia of the streptozotocin diabetic mice were also

reduced by Xiaoke, and the effects lapsed after treatment was withdrawn.

Xiaoke did not significantly alter plasma insulin concentrations.

Consumption of the Xiaoke extract by insulin-treated diabetic BB/E Wistar

rats did not affect glycaemic control or body wt. When insulin treatment was

reduced and discontinued, Xiaoke failed to prevent the progression of

severe hyperglycaemia and weight loss. The results suggest that the slowly

generated antihyperglycaemic effect of Xiaoke in streptozotocin diabetic

mice may involve an extrapancreatic effect on food intake, glucose

production or glucose clearance. However, as evidenced in BB/E rats,

Xiaoke does not substitute for insulin in the absence of endogenous insulin

secretion. PMID: 3552362 [PubMed - indexed for MEDLINE]

Hale PJ, Horrocks PM, Wright AD, Fitzgerald MG, Nattrass M, Bailey CJ.

Xiaoke tea, a Chinese herbal treatment for diabetes mellitus. Diabet Med.

1989 Nov;6(8):675-6. Diabetic Clinic, General Hospital, Birmingham, UK.

Xiaoke tea, a traditional Chinese treatment for diabetes mellitus, lowered

blood glucose concentrations in streptozotocin diabetic mice. To investigate

Xiaoke clinically, a double-blind crossover study was undertaken in 12 non-

insulin-treated diabetic patients. Xiaoke tea and ordinary tea (infusion of

2.72 g, 4 times daily) were consumed in random order for 4 weeks. A

standard breakfast meal was taken before and after each treatment period.

Xiaoke did not significantly affect glycosylated haemoglobin, basal or post-

breakfast serum glucose and insulin concentrations, intermediary

metabolite concentrations, triglyceride and cholesterol. No adverse side-

effects of Xiaoke were evident. Publication Types: Clinical Trial Randomized

Controlled Trial PMID: 2532099 [PubMed - indexed for MEDLINE]

Piao CL, Nan HM, Jiang Z, Nan Z. [Effect of combined therapy of xiaoke

shen'an capsule and western medicine in diabetic nephropathy] [Article in

Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Jul;25(7):650-2.

Department of Endocrinology, Hospital Affiliated to Changchun College of

Traditional , Changchun.

Piaochunli981027 OBJECTIVE: To observe the therapeutic

effect of xiaoke shen' an capsule on diabetic nephropathy. METHODS:

Ninety patients with diabetic nephropathy were randomly divided into two

groups, the patients in the control group (CG) were treated with

conventional western medicine, and those in the treated group (TG) were

treated with combined therapy of xiaoke shen'an capsule and conventional

western medicine. The treatment course of both groups was 8 weeks, and

the therapeutic effect related indexes were measured before and after

treatment. RESULTS: The curative rate was 85.0% and 73.3% in CG and

TG respectively, it was better in TG than that in CG (P < 0.05). Indexes

such as fasting blood glucose, glycosylated hemoglobin, blood pressure,

quantity of 24h urinary protein, urinary albumin excretion rate, renal

function, blood lipids and hemoreheologic parameters were significantly

different before and after treatment in TG (P < 0.05 or P < 0.01). As

compared with CG, some of these indexes after treatment were superior to

those in CG (P < 0.01 or P < 0.05). CONCLUSION: Combined therapy of

xiaoke shen'an capsule and conventional western medicine has definite

therapeutic effect on diabetic nephropathy. Publication Types: Clinical Trial

Randomized Controlled Trial PMID: 16089148 [PubMed - indexed for

MEDLINE]

http://www.tourasia.net/mellitus/xiaoke/ says:

Xiaoke Wan for Diabetes: The pill is a drug for diabetes, with actions of

nourishing kidney and yin, benefiting vital energy and promoting the

production of body fluid. It is indicated for cases with polydipsia, polyuria,

potyphagia, emaciation, fatigue, sleeplessness, lumbago, and high glucose

level in the blood and urine. This diabetes pill is proved to be highly

effective

with small dosage and few side effect, and is especially effective for

incipient, mild, moderate and stable cases of diabetes mellitus in which the

pancreas is still partially functioning. Since the quality of this diabetes pill

is

stable and its effectiveness is definite,this preparation was awarded

" Famous Trade Brand Product " by Guangdong Province in 1996. Trade

Mark: Zhong Yi Brand Diabetes Medicine Description: Black concentrate

pills; taste, sweet, sour , slightly astringent. , Ingredients: Radix Astragali,

Radix Rehmanniae and Radix Trichosanthis,Glibenclamide (2.5mg per 10

pills). Dosage: 1. 25 - 2.5g (about 5 - 10 diabetes pills) for oral use with

boiled water after meal, thrice daily.

See also:

http://www.i-c-m.org.uk/Journal/2003/oct03/009.htm

and

www.moh.govt.nz/moh.nsf/by+unid/0DE600666A1711A8CC256CCF0064D

574?Open

http://www.cantonbrand.com/en/product/viewProduct.asp?productid=116

says: Product Name: XIAOKE PILLS REFERENCE Category: Chinese

Patent Medicines Company: GuangZhou ZhongYi Pharmaceutical Co.Ltd

Introduction INGREDIENTS£º Radix Puerariae, Radix Rehmanniae, Radix

Astragali, Radix Trichosanthis, Stylus Zeae Maydis, Fructus Schisandrae

Sphenantherae, Rhizoma Dioscoreae and Glibenclamide. DESCRIPTION:

Black coated concentrated pills; sweet, sour and slightly astringent in taste.

ACTIONS AND INDICATIONS: Nourish kidney-yin, benefit qi, promote

generation of body fluid. Indicated for diabetes mellitus due to deficiency of

qi and yin (non-insulin dependent diabetes) manifested as thirst, polydipsia,

polyphagia, polyuria, polyorexia, emaciation, tiredness, fatigue, shortness of

breath, indolent about speaking. USAGE AND DOSAGE: For oral use, 5-10

pills after meal, 2-3 times daily. According to the state of illness, increased

of 5 pills once progressively but not exceeded 30 pills daily, when increased

of 20 pills daily, at least divided into 2 times for oral use. During a

satisfactory result is obtained, reduced the dosage to a maintenance dose

and directed by physician. CONTRAINDICATIONS: 1. Forbidden to use

sulfonylurea (antidiabetic) during applied this preparation, in case combined

use with other antidibetics simultaneously, the patients should be directed

by physician. 2. Forbidden for pregnant women foster-nurse, insulin

dependence, and those are unsuitable for glibenclamide. 3. Forbidden for

cases with allergic reaction of sulfonamides. 4. Forbidden for cases

complicated with ketoacidosis, coma, severe burn, infection, severe

traumatic injury and great operation. 5. Forbidden for cases with hepatic or

renal insufficiency. 6. Forbidden for cases with leukopenia, agranulocytosis

or thrombocytopenia. 7. Forbidden drinking.

Best regards,

June 23, 2006

I appreciate your replying to my question.

I had a client come to me with the question saying it was the only

thing that help his blood sugar, but he couldn't find it any more.

Thanks again,

Chris

In a message dated 6/22/2006 10:19:35 PM Eastern Standard Time,

writes: