cholesterol/statin drug information

[Guest guest]

for all who want to know more about the dangers of statin .... cholesterol lowering medications I post the following links:

 

I am PERMANERNTLY damaged as a result of being on multiple statin medications years ago, take care the same does NOT happen to you:

 

http://www.newmediaexplorer.org/chris/2008/04/23/treatment_of_statin_damage.htm

follow all the links there is a wealth of information you can pass along to your dear friends

 

 

http://www.medicationsense.com/articles/jan_dec_08/statin_sidefects012108.html

 

 

 

 

Abstract for presentation at Australian Association of Neurologists Annual Scientific Meeting 2006

Statins may initiate a persisting immune-mediated myopathy and myositis: a study of 10 cases

Merrilee Needham, Queen Elizabeth II Medical Centre, Australia Dr Vicki Fabian, Royal Perth Hospital and Fremantle Hospital, Australia Dr W Knezevic, Queen Elizabeth II Medical Centre, Australia Dr Philippa Lamont, Queen Elizabeth II Medical Centre, Australia Dr P Panegyres, Queen Elizabeth II Medical Centre, Australia Paul Zilko, Queen Elizabeth II Medical Centre, Australia Frank Mastaglia, Queen Elizabeth II Medical Centre, Australia

Background: Statins may cause a necrotising myopathy and hyperCKaemia which are usually reversible once the drug is discontinued. Aim: To investigate the muscle pathology in a group of 10 patients who developed myopathic symptoms during statin therapy and in whom symptoms persisted or progressed after withdrawal of the drug.Methods: All patients were examined by a neurologist or rheumatologist on more than one occasion and had a muscle biopsy after cessation of statin therapy. Immunohistochemical techniques for MHC Class I and II antigen expression and demonstration of macrophages and lymphocyte subsets were applied in addition to routine biopsy stains.Results: In 4 of the 10 patients the biopsy showed an active necrotizing inflammatory myopathy and in another features of inclusion body myositis. In the remaining cases the biopsy demonstrated a necrotizing myopathy without inflammation but with diffuse upregulation of MHC-I in 5 cases and non-specific myopathic changes in one.Conclusions: Our findings suggest that statin therapy may initiate an immune-mediated myopathy or myositis with progressive symptoms after withdrawal of the drug, or unmask a pre-existing myopathy. The underlying immunopathogenic mechanisms in such cases require further investigation.

Conference Organiser - ICMS Pty Ltd