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Health Benefits DMSO: Dimethyl Sulfoxide

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via http://www.spinalrehab.com.au/updates/DMSO%20-%20Information.htm

Dimethyl Sulfoxide

Also known as: DMSO;

Dimethylsulphoxide; RIMSO

Description

Dimethyl Sulfoxide is a Sulfuric

Compound originally used as an industrial solvent that since the 1960's

has been recognized for various therapeutic benefits - its usage has been

highly controversial.

 

Health Benefits of DMSO

Detoxification

DMSO (administered intravenously)

facilitates the excretion of excessive accumulated Amyloid (amyloidosis).

 

DMSO (applied topically) protects the body against the toxic effects of

X-Rays [scientific research - animals].

Excretory System

DMSO (50% solution applied

topically to the Feet) alleviates Foot Odour (Bromidrosis) [observations

to date indicate that the longer that the DMSO solution is allowed to

remain in contact with the feet, the longer thereafter the Foot Odour

subsides].

DMSO has been approved by the FDA in the treatment of Interstitial

Cystitis (IC) [scientific research - double blind human studies: DMSO

markedly improves the condition of 93% of IC patients]:

DMSO treatment for IC should be

administered by a suitably qualified medical practitioner - the usual

treatment protocol involves the administration of a 50% solution of DMSO

intravesically (i.e. instilled into the Urinary Tract) every 2 weeks for 2

sessions of 4 treatments each.

Immune System

DMSO helps to alleviate Allergies

(by "unfolding" Cell Membranes, DMSO permits more Antigens to

attach to Cell Membranes, where they are more effectively neutralized by

Antibodies).

 

DMSO significantly lessens Inflammation and swelling by reducing

inflammatory exudate and enhancing the development of granulation tissue.

DMSO facilitates the movement of Macrophages around and through the body's

tissues (by increasing the body's production of Migration Inhibitory

Factor [MIF]).

Metabolism

DMSO deactivates Hydroxyl Free

Radicals (DMSO combines with Hydroxyl Free Radicals to form Dimethyl

Sulfone and Water which are then readily excreted from the body).

Musculoskeletal System

DMSO (either applied topically or

consumed orally) minimizes the damage caused by crushing injuries such as

Bruises and pulled or wrenched Muscles :

- DMSO is a powerful scavenger of

Hydroxyl Free Radicals which are responsible for much of the damage caused

in these injuries.

- If DMSO is applied quickly to an injury it is possible to eliminate

entirely any Bruising.

DMSO alleviates Rheumatoid

Arthritis (by deactivating Hydroxyl Free Radicals which are one of the

principal causes of the Inflammation and Pain associated with Rheumatoid

Arthritis).

Nervous System

DMSO (DMSO/Amino Acid Combination)

therapy partially reverses some of the abnormalities that occur in Down's

Syndrome [scientific research - humans: DMSO/Amino Acid therapy causes a

tendency towards accelerated maturity in Down's Syndrome children treated,

with marked progress in language integration. In some cases, this therapy

causes the physical appearance of Down's Syndrome children to more closely

resemble that of normal children].

DMSO markedly reduces the

formation of the abnormal Antibodies that are characteristic of Myasthenia

Gravis [scientific research - animals: note that this finding has not yet

been confirmed for humans]:

- As a secondary means of

alleviating Myasthenia Gravis, DMSO also inhibits the actions of

Cholinesterases (similarly to the Anticholinesterase Pharmaceutical Drugs

employed by orthodox medicine in the treatment of Myasthenia Gravis).

DMSO alleviates Pain by impeding

the conduction of Nerve Impulses relating to the Pain sensation in the

smaller Nerve Fibers.

 

DMSO (1 gram per kg of body weight administered intravenously in a 40%

solution within 1 hour of the occurrence of quadriplegia) helps to prevent

Paralysis following injuries to the Brain or Spinal Cord (by inhibiting

the Free Radical damage that causes Paralysis) [scientific research].

DMSO (1 gram per kg of body weight

administered intravenously into the Spinal Cord in a 40% solution within 1

hour of the occurrence of quadriplegia) helps to prevent Paralysis

following injuries to the Spinal Cord that would otherwise cause

Quadriplegia [scientific research - animals & humans: this treatment

often results in total avoidance and reversal of paralysis/quadriplegia].

 

DMSO (administered intravenously within 4 hours, and preferably within 90

minutes of its occurrence) helps to prevent the after-effects (including

Paralysis) following (the Embolic and Hemorrhagic forms of) Stroke

[scientific research - animals].

Respiratory System

DMSO (placed directly into the

nostrils) can open the blocked Sinuses that are associated with Sinusitis

[scientific observation -

humans: relief occurs within minutes].

Skin

DMSO (applied topically)

alleviates the lesions that occur as a result of Herpes Zoster (Shingles).

 

DMSO (applied topically) helps to dissolve the (skin) tissues involved in

Scarring [scientific research - humans: a concentration of 50-80% DMSO

applied topically 3 times per day flattens raised external scars after

several months - microscopic examination of the skin will reveal loosening

of Collagen bundles].

DMSO (applied topically) potently

alleviates Scleroderma (where Scleroderma affects the Skin).

DMSO Enhances the Function of

these Substances

DMSO enhances the bioavailability

of many substances (it has the capability to transport many therapeutic

substances across the body's Cell Membranes without altering the integrity

of Cell Membranes). By increasing their bioavailability, DMSO permits a

lower dosage of some drugs than would otherwise be required.

Enzymes

DMSO inhibits the release of

Cholinesterases (i.e. it possesses similar properties to Pharmaceutical

Anticholinesterases).

Hormones

When exogenous forms of endogenous

Steroids (including Testosterone and the Hydrocortisone form of Cortisone)

are dissolved in DMSO prior to topical application, their topical

bioavailability increases by 300% [scientific research - humans].

Immune System Chemicals

DMSO can enter Cells to prime or

activate the sub-cellular mechanisms involved in the production and

release of Migration Inhibitory Factor (MIF) and in addition, produces a

cofactor that enhances MIF or has MIF-like activity.

Neurotransmitters

DMSO facilitates the transport of

(supplemental) Gamma Aminobutyric Acid (GABA) across the Blood-Brain

Barrier (without DMSO as a carrier-vehicle, GABA poorly crosses the

Blood-Brain Barrier).

Pharmaceutical Drugs

DMSO enhances the bioavailability

and effectiveness of many Anti-Viral Pharmaceutical Drugs (DMSO

facilitates their transport directly across Cell Membranes into Cells

where they are most potent against Viruses).

DMSO facilitates the absorption of Penicillins - i.e. Penicillins can be

dissolved in DMSO and applied topically where they are efficiently

transported across the Skin.

These Substances Enhance the

Function of DMSO

Antioxidants

Antioxidants counteract DMSO's

tendency to convert to Sulfoxide Free Radicals.

 

Side Effects of DMSO Therapy

Excretory System

DMSO (temporarily) causes

Halitosis in the form of a garlic-like odor of the breath (this odor is

very unpleasant and appears to be the major practical drawback in the

usage of DMSO).

Free Radicals

After chemically reacting with

Hydroxyl Free Radicals, DMSO is converted to a Sulfoxide Free Radical.

Skin

Itching is a common side effect of

topical DMSO therapy - this side effect can usually be avoided by diluting

the concentration of DMSO. Skin Rashes are a common side effect of topical

DMSO therapy - this side effect can usually be avoided by diluting the

concentration of DMSO.

Myths Dispelled

Eyes/Eyesight

DMSO is often avoided by orthodox

medical practitioners due to UNFOUNDED fears that it can cause Cataracts

and other changes within the human Eye:

- This aspect of DMSO toxicology

has been extensively tested in both animals and humans: the results

clearly show that DMSO does NOT cause Cataracts in humans even at

extremely high dosages for periods up to two years. No adverse changes

were found in human or monkey eyes after prolonged, high levels (up to 30

times the usual dosage) of DMSO treatment.

 

- The myth regarding DMSO's toxicity to human Eyes arises from toxicology

studies that show that DMSO DOES cause Cataracts and other changes in the

Eyes of both dogs and rabbits, however the toxicity of DMSO to the eyes of

these animals definitely differs from that of humans.

Bioavailability

DMSO has the ability to pass

through every tissue and Cell Membrane of the body except the Enamel of

Teeth, fingernails and Hair without destroying the integrity of these

tissues and Cell Membranes (i.e. it is a membrane penetrate). DMSO also

permits the passage of a number of compounds across the barriers of Cell

Membranes.

 

DMSO is readily absorbed when administered topically onto human Skin -

peak levels occur after 4-8 hours. Topical administered DMSO is slightly

less bioavailable than orally ingested DMSO.

Orally ingested DMSO is also

rapidly absorbed and reaches a blood serum peak in 4 hours and becomes

undetectable after 120 hours.

 

DMSO readily crosses the Blood-Brain Barrier (this property of DMSO allows

its utilization as an effective vehicle for transporting other substances

that may not normally cross the Blood-Brain Barrier).

DMSO is excreted from the body

partly in an unchanged state and partly as its metabolite - Dimethyl

Sulfoxone (DMSO2).

DMSO as part of the Global

Sulfur Cycle

DMSO is an intermediate product of

the methyl-S-methane global Sulfur cycle which distributes bioavailable

Sulfur for all animal and plant life. Approximately 85% of Sulfur (for

life) is derived from the pathway:

- Sulfonium Salts >

Dimethylsulfide > Dimethyl Sulfoxide (DMSO) > Methylsulfonylmethane

(MSM)

- Sulfonium Salts (produced by

phytoplankton in Water) yield the volatile thioether named Dimethylsulfide

which is released into the upper atmosphere.

- Sunlight catalyzes the oxidation

of Dimethylsufide to DMSO.

- DMSO is further oxidized in the

upper atmosphere (by Sunlight) to form MSM.

- This MSM is then concentrated

into raindrops which return to the surface of the earth.

- Plants absorb and accumulate

this MSM (and use some of this MSM for bulding Sulfuric compounds).

Forms of DMSO

DMSO is manufactured in liquid and

gel forms.

Dosage Recommendations

Long Term Dosage Reduction

Less DMSO is required to achieve

therapeutic results as time passes (i.e. the cumulative effects of DMSO

appear to increase with the passage of time).

Topical Therapeutic Dosage

Protocol

The liquid form of DMSO is the

most effective form of topical DMSO application, although most people

prefer the gel form.

 

Topically applied DMSO is not rubbed onto the Skin but painted or patted

on with a thin coating.

 

The concentration of DMSO used in topical treatments should ideally be

individualized on a cases by case basis - the optimal concentration varies

from 50-80% DMSO.

The Face and Neck are more

sensitive to topical DMSO than other parts of the body - the maximum

concentration of DMSO for application to the Face or Neck should be no

greater than 50%.

 

Topical applications of DMSO should not exceed 70% in areas of the skin

affected by poor circulation. It is desirable to commence topical DMSO

treatment at low concentrations until Skin tolerance builds up.

The Skin must be clean, dry and

unbroken before topical application of DMSO.

Aloe Vera gel is an excellent remedy for the temporary Skin irritation

that sometimes occurs as a result of topical DMSO therapy.

 

Oral DMSO Dosage Protocol

The usual oral dosage of DMSO is 1

- 2 teaspoons (5 - 10 ml) per day.

Oral DMSO is normally mixed with Tomato juice or Grape juice to mask its

"foul" taste.

Intravenous Injections of DMSO

Dosage Protocol

Up to 20 cc DMSO that has been

diluted to a 25% concentration with sterile water is often administered

via intravenous injection by suitably trained physicians for the treatment

of the more serious degenerative diseases.

 

Injected DMSO is not administered by infusion or by the drip technique but

is administered by the "slow push" method which involves a slow

push into the bloodstream all at once.

Intravenous Drip DMSO Dosage

Protocol

The slow intravenous drip method

is applied over a 2-3 hour period. It involves the addition of 50-100 cc

DMSO to a 500 cc glucose or saline solution, dripped into a vein in the

patient's arm. This method should only be administered by a suitably

qualified physician.

Commercial Availability of DMSO

Industrial Grade DMSO

Caution: many of the industrial

grade DMSO solutions intended for use as solvents have an acid or Acetone

contamination of several percent. Acetone contamination can lead to

serious medical consequences - because of its small molecular weight,

Acetone is readily carried into the blood by Acetone-contaminated DMSO.

Source of Commercial DMSO

In the USA, commercially

manufactured DMSO is derived from Lignin.

DMSO/Water Combinations

Brand Composition Description

RIMSO-50: 50% DMSO

50% Water Pure pharmaceutical grade DMSO manufactured by Terra

Pharmaceuticals Inc. of Buena Park, California.

Supplied in 50 cc vials.

Domosa: 90% DMSO

10% Water Pharmaceutical grade DMSO suitable for injection or for further

dilution with water for topical or oral ingestion.

Supplied in pint bottles and in gallon bottles for veterinary use.

Dimexide: Brand name for DMSO in Russia.

 

DMSO/Amino Acid Combinations

Brand Country Available

Description

Akron:

Merinex: Argentina

Chile DMSO combined with Amino Acids (Gamma-Aminobutyric Acid [GABA],

Gamma-Amino-Beta-Hydroxybutyric Acid [GABOB] and Acetylglutamine).5 ml

ampoules (for intramuscular injection) and capsules (for oral

administration).The dosage protocol for DMSO/Amino Acid combinations

involves one intramuscular injection every 2nd day and 2 or 3 capsules

orally each day. Injections are suspended every 40 days for a rest period

of 1 month during which capsules are still used. This program of treatment

normally lasts for 1 year.Akron and Merinex are not approved by the FDA

for use in the USA.

 

Vasoactive DMSO Combinations

Ipran is the trade name of a

vasoactive DMSO product, however this product has not been approved for

use in the USA.

DMSO's Chemical Structure

The DMSO molecule is ten-sided with a center occupied by a Sulfur atom. It

contains two methyl groups - an oxygen atom and a nonbinding electron pair

- located at the points of the tetrahydron.

Molecular weight: 78.15

Freezing point: 68 degrees Fahrenheit

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