Testosterone Replacement Therapy

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Testosterone Replacement Therapy

_http://www.hormoneandlongevitycenter.com/testoteronetreatments1/_

(http://www.hormoneandlongevitycenter.com/testoteronetreatments1/)

_Treatment with Testosterone_

(http://www.hormoneandlongevitycenter.com/testoteronetreatments1#1)

_Scientific Review of Testosterone Replacement in Men_

(http://www.hormoneandlongevitycenter.com/testoteronetreatments1#2)

_Testosterone Prevents Mental Decline in Aging Males_

(http://www.hormoneandlongevitycenter.com/testoteronetreatments1#3)

_Testosterone and Women_

(http://www.hormoneandlongevitycenter.com/testoteronetreatments1#4)

Treatment With Testosterone

Many men suffer needlessly because their testosterone is never checked or

the wrong test is ordered. Men as young as 25 to 30 years in age are

presenting with low levels of testosterone, which was not the case 10 or 20

years

ago. This is possibly a result of environmental toxins, plastics,

pesticides, pollutants and/or xenoestrogens in the environment. A large

percentage

of men who have been told their testosterone is fine actually have low

testosterone. Often the total amount of testosterone is read as adequate, but

the amount of usable testosterone is low. Men with low testosterone may have

subtle to profound symptoms, ranging form poor motivation, anxiety, weight

gain, and loss sense of well being to profound depression, and loss of sex

drive. Men with low testosterone cannot only enjoy an improved quality of

life with testosterone supplementation, but it will also provide a

significant decreased risk for heart disease, cancer, diabetes and death.

Low testosterone in men can result in:

1. Fatigue, tiredness or loss of energy

2. Depression, low or negative mood

3. Irritability, anger or bad temper

4. Anxiety or nervousness

5. Loss of memory or concentration

6. Relationship problem with partner

7. Loss of sex drive or libido

8. Erection problems during sex

9. Loss of morning erections

10. Decreased intensity of orgasms

11. Backache, joint pains or stiffness

12. Heavy drinking, past or present

13. Loss of fitness

14. Feeling over-stressed

15. Loss of drive and competitive edge

16. Stiffness and pain in muscles and joints

17. Falling level of fitness

18. Decreased effectiveness of workouts

Testosterone replacement and optimization can result in:

1. Decreased aging of heart and circulation

2. Decreased risk of heart attacks and strokes

3. Decreased risk of diabetes

4. Decreased body Fat

5. Increased lean muscle

6. Increased blood flow to brain

7. Decreased brain aging

8. Improved memory and intelligence

9. Decreased risk of dementia and Alzheimer's

10. Increased sense of well being

11. Improved Sexual function

12. Decreased Osteoporosis

13. Decreased risk of prostate cancer

Average testosterone levels in older vs. younger men

 

Low testosterone linked to long-term risk of death in relatively healthy

adult men

ENDO 2007: The Endocrine Society Research Summaries Book June 5, 2007

This study is another major report linking deficiency of testosterone in

relatively healthy men with increased death from all causes, over time. “We

have followed these men for an average of 18 years and our study strongly

suggests that the association between testosterone levels and death is not

simply due to some acute illness, " said Gail Laughlin, Ph.D., assistant

professor and study author.

In the study, Laughlin and co-workers looked at death, no matter the

cause, in nearly 800 men, ages 50 to 91 years, who were living in California

since 1970. At the beginning of the 1980s, almost one-third of these men had

suboptimal blood testosterone levels for men their age.

The group with low testosterone levels had a 33 percent greater risk of

death during the next 18 years than the men with higher testosterone. This

difference was not explained by smoking, drinking, physical activity level or

pre-existing diseases (such as diabetes or heart disease). Men with low

testosterone were more likely to have elevated markers of inflammation,

called inflammatory cytokines, which contribute to many diseases. Men with low

testosterone were also shown to be three times more likely to have a waist

measurement more than 40 inches, low HDL (good) cholesterol, high

triglycerides (levels of fat in the blood), high blood pressure or high blood

glucose

(blood sugar).

This study is further confirmation of previous studies that demonstrate an

increased risk of morbidity and mortality with low or low normal

testosterone:

· In a study of male veterans, low serum testosterone levels were

shown to increase the risk of death in the next few years by 88%, according

to a report in the Archives of Internal Medicine.

· In an earlier study, Dr. Molly M. Shores and colleagues from the

University of Washington in Seattle and showed an increase in 6-month

mortality among men with low testosterone levels.

· The another study published in a 2006 edition of the Archives of

Internal Medicine involved 858 male veterans who were at least 40 years of

age, prostate cancer-free, and had repeated testosterone levels taken

between 1994 and 1999 and were followed for an average of 4.3 years. It was

found that men with low or low normal testosterone had a 23-75% increased risk

of dying.

Scientific Review of Testosterone Replacement in Men

1. Bringing testosterone form low normal to high normal lowers the risk

for heart disease by 60%

The Journal of Clinical Endocrinology & Metabolism. Aug 2002. Vol. 87, No.

8 3632-3639

2. 2 year study of low dose testosterone on libido in men

(Clin Endocrinol Metab 1997)

 

3. Dihydrotestoerone reduces prostate size

Ann Med 1993 Jun;25(3):235-41

3. Testosterone Improves Sexual Function, Mood, Muscle Strength, and Body

Composition Parameters in Hypogonadal Men Improved

a. Sexual function

b. mood

c. muscle strength, leg > arm

d. Subjects did not exercise

e. Improved lean body mass and fat mass

f. Correlated with serum level of T obtained

Study showed that these benefits were not obtained with testosterone

patches (Testosterone patches are too weak for most patients)

5. Testosterone supplementation increased working memory in men

Janowsky J et al. Sex steroids modify working memory J Cogn Neurosci 2000

May;12(3):407-14

6. Testosterone replacement reduces the risk of Alzheimer’s Disease by

preventing the production of beta amyloid precursor protein.

Gouras GK et al. Proc Natl Acad Sci U S A 2000 Feb 1;97(3):1202-5

7. Testosterone levels correlates with and testosterone replacement

improves cognitive function

Hormones and Behavior 1998; 33(2):85-94.

J Clin Endocrinol Metab 1999 Oct;84(10):3681-5

8. Testosterone replacement is more effective than antidepressants for

depression

Am J Psychiatry 157:1884, November 2000

Androl 1992 Jul-Aug;13(4):297-304

9. Low testosterone associated with fatigue and testosterone replacement

increases sense of well being

Many patients are able to stop Antidepressants after being treated with

testosterone

Geriatr Psychiatry Neurol 2000 Summer;13(2):93-101

10. The lower the active testosterone level, the higher the risk for heart

attack.

Circulation 1999 Apr 6;99(13):1666-70

- Acute anti-ischemic effect of testosterone in men with coronary artery

disease.

- Testosterone improves exercise induced ST depression

- Dilates coronary arteries

“Short-term administration of testosterone induces a beneficial effect on

exercise induced myocardial ischemia in men with coronary artery disease.

This effect may be related to a direct coronary-relaxing effect.â€

11. Men with heart disease have significantly lower

- Total testosterone

- Free testosterone

- Bioavailability testosterone

- Men with coronary artery disease have lower levels of androgens than men

with normal coronary angiograms.

Eur Heart J 2000 Jun;21(11):890-4

12. Low testosterone increases the risk of heart disease and more optimal

levels decrease the risk of heart disease.

Int J Obes Relat Metab Disord, July 2003

13. Low testosterone levels increase the risk of prostate cancer and

testosterone replacement is expected to reduce risk of prostate cancer.

Dihydrotestosterone and testosterone levels in men screened for prostate

cancer: a study of a randomized population.

Br J Urol 1996 Mar;77(3):433-40

- DHT is lower in prostate cancer patients

- DHT is lower in prostate cancer patients

- DHT is lower in more advanced tumors

- PSA and DHT have an inverse relationship (high DHT lower PSA)

14. Testosterone replacement is better than exercise to reduce body fat,

gain lean muscle and improve strength and effects of testosterone are

improved with exercise (Synergistic effect)

J Endocrinol 2001 Jul;170(1):27-38

 

15. Testosterone replacement reduces risk of diabetes

- Testosterone replacement decreases insulin resistance

- Low levels of testosterone play a role in the development of type 2

diabetes

- Elevated insulin decreases testosterone levels resulting in a vicious

cycle of worsening insulin resistance and reduced testosterone levels

- Testosterone replacement breaks this cycle

- Low testosterone is associated with Syndrome X, hypertension, type 2

diabetes and heart disease.

Journal of American Epidemiology 1996

Int J Obes Relat Metab Disord 2000

Mayo Clin Proc 2000 Jan;75 Suppl:S61-4

Diabetes Care. 2000 Apr;23(4):490-4

Metabolism 1997 May;46(5):526-9

16. Dihydrotestoterone with NSAIDS kills prostate cancer cells

Cancer Chemother Pharmacol, 2002; 49(3):179-86

17. Using HCG to boost testosterone levels results in significant

improvement in prostate enlargement and symptoms

Journal of Urology 2003

18. Testosterone replacement decreases fat and increases lean muscle.

Bhasin et al. journal of Endocrinology and Metabolism, 2003

19. Testosterone replacement speeds healing and result s in shortens

hospital stays.

Journal Am Geriatr Soc, 2002

20. Pesticides reduce testosterone production in men

Biology and Reproduction, 2003

 

Testosterone Prevents Mental Decline in Aging Males

 

 

Longitudinal Assessment of Serum Free Testosterone Concentration Predicts

Memory Performance and Cognitive Status in Elderly Men

The Journal of Clinical Endocrinology & Metabolism. Vol. 87, No. 11

5001-5007

Abstract: Circulating testosterone (T) levels have behavioral and

neurological effects in both human and nonhuman species. Both T concentrations

and

neuropsychological function decrease substantially with age in men. The

purpose of this prospective, longitudinal study was to investigate the

relationships between age-associated decreases in endogenous serum T

(testosterone) and free T concentrations and declines in neuropsychological

performance.

Participants were volunteers from the Baltimore Longitudinal Study of

Aging, aged 50–91 yr at baseline T assessment. Four hundred seven men were

followed for an average of 10 yr, with assessments of multiple cognitive domains

and contemporaneous determination of serum total T, SHBG, and a free T

index (FTI). We administered neuropsychological tests of verbal and visual

memory, mental status, visuomotor scanning and attention, verbal

knowledge/language, visuospatial ability, and depressive symptomatology.

Higher free testosterone was associated with better scores on visual and

verbal memory, visuospatial functioning, and visuomotor scanning and a

reduced rate of longitudinal decline in visual memory. Men classified as

hypogonadal (low testosterone) had significantly lower scores on measures of

memory and visuospatial performance and a faster rate of decline in visual

memory. These results suggest a possible beneficial relationship between

circulating free Testosterone concentrations and specific domains of cognitive

performance in older men.

 

Testosterone and Women

 

At Last A True Aphrodisiac Is Discovered

Archives of General Psychiatry/Vol. 57

 

Researchers in the Netherlands studied genital arousal in women after the

administration of testosterone and reported their findings in the February

2000 issue of the Archives of General Psychiatry. Sublingual testosterone

was shown to trigger sexual desires, fantasies and lust along with an

increase in vaginal arousal.

 

 

 

 

[Guest guest]

I have used testosterone cream for a number of years. I get it from Women's

International Pharmacy and it costs about $40 for a two month supply. But it

worked for awhile then my T numbers dropped back into the low zone.

 

Now I'm giving myself testosterone shots Three times a week. It's a little more

expensive but I can tell it's effective. This is Natural T no something some

Big Pharma mixed up in a lab. It's compounded locally. I'm 78 years old. I'll

be doing a blood collection within the next 6 weeks so I'll actually be able to

quantify that the shots can and do raise my T level.

 

Personally I would like to see some numbers that support use of herbs and what

have you thinking that it raises the testosterone level, needless to say I'm

skeptical and that comes from a person that has taken handfuls of supplements on

a daily basis for the past 30 years.

 

Jack

 

 

[Guest guest]

The testosterone (T) is carried in a oil base carrier, it's true T not the lab

kind. Also, to my dismay there's a preservative the pharmacist said it had to

be in there otherwise the T would crystallize. Dr. does not like this either

but he said after discussin with the pharmacist agreed on maximum minimization.

Initially I had a rash in the area of the injection (the hip) and became

concerned that's when I questioned it with doctor and then the pharm. Decided

to continue and see if the reaction would abate and apparently it has because I

detect no more rash. Other patients have reported similar experiences.

 

If I could truly zero in on some herbs that would raise the T to the required

level (1200) I would certainly go in that direction. With that said someone is

probably certain to question the 1200 figure because most lab sheets say 700-800

is normal but Dr. says that's incorrect. The present level used as " normal " are

based on the average of a large data base using todays averages. The average

has been going down for years due to the amount of estrogen in our environment.

Doctor uses a figure that was valid 30 years ago which makes a lot of sense to

me. I have experienced the 1200 level for a period of time and I'll tell you

it's profound.

 

It would be nice if we could zero in on some herbs that do the job.

 

Jack

 

, " Jack Milliorn "

<jack.mill wrote:

>

> I have used testosterone cream for a number of years. I get it from Women's

International Pharmacy and it costs about $40 for a two month supply. But it

worked for awhile then my T numbers dropped back into the low zone.

>

> Now I'm giving myself testosterone shots Three times a week. It's a little

more expensive but I can tell it's effective. This is Natural T no something

some Big Pharma mixed up in a lab. It's compounded locally. I'm 78 years old.

I'll be doing a blood collection within the next 6 weeks so I'll actually be

able to quantify that the shots can and do raise my T level.

>

> Personally I would like to see some numbers that support use of herbs and what

have you thinking that it raises the testosterone level, needless to say I'm

skeptical and that comes from a person that has taken handfuls of supplements on

a daily basis for the past 30 years.

>

> Jack

>

>

[Guest guest]

Is this for you or your husband?

 

I have no idea how your doctor would respond to you as a female. Female

Testosterone levels are much lower in the female than the male for obvious

reasons, you wouldn't want to grow a beard I don't think, plus I don't know how

many other changes would occur, like large muscles?

 

With that said I have read that female do take very small amounts to balance

their hormones. Specifically the thing that seems to trigger this application

in a female is lack of libido, it's very effective for that as I understand it.

 

If your inquiry is for your male partner then I have a different answer which

follows.

 

For the Male:

To try to answer your questions. Hopefully your Doctor would respond the way

you want. I would just tell him you would like to take the injectable

" Testosterone " My prescription is " inject 0.2ml on Monday, Wednesdays and

Fridays. The bottle contains 10ml total, that would provide 50 injections.

Have you had a lab so you know what your current Testosterone level is? If not

it's essential you do that and I'm sure, providing your doctor agrees, you will

have to do that before he would prescribe Testosterone.

 

If he wants to prescribe a patch bear in mind that it's artificial and make sure

the injectable is real Testosterone.

 

To answer your other question. The syringes are disposable and the needle is

really thin so you can hardly tell when it goes in. Doctor told me to

inject it in the hip alternating each time. There's a slight stinging sensation

but it only lasts for a short time.

 

My doctor is a Holistic doctor and he uses both allopathic and holistic methods.

He believes and I agree that if the hormones are not balanced you are not going

to do well especially Testosterone in the Male much less so in the female but

nevertheless very important for the female libido.

 

Jack