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Herx Reaction Fundamentals

_http://lymebook.com/blog/the-recovery-process/herx-reactions/herx-reaction-

fundamentals/_

(http://lymebook.com/blog/the-recovery-process/herx-reactions/herx-reaction-fund\

amentals/)

By _Bryan Rosner_ (http://lymebook.com/blog/author/admin/) on Apr 7, 2008

in _Herx Reactions_

(http://lymebook.com/blog/category/the-recovery-process/herx-reactions/) , _The

Recovery Process_

(http://lymebook.com/blog/category/the-recovery-process/)

 

 

You get to see more and more of my book, _Lyme Disease and Rife Machines_

(http://www.lymeandrifebook.com/) , online for free these days! This post is

an excerpt from the book addressing herxheimer reactions, also known as

**herx reactions.** Have no clue what that is? Keep reading to find out.

Believe it or not, the herx reaction is one of the most important topics you

will ever study as a Lyme disease patient or practitioner.

Understanding Lyme Disease symptoms

The first step to understanding the recovery process is reviewing the herx

reaction. To appreciate the herx reaction, it is necessary to first

examine regular, ongoing Lyme Disease symptoms.

Consider what happens when you get the flu: You get body aches, chills,

fever, nausea, lack of appetite, fatigue, lethargy, and sometimes additional

symptoms. What you may not know is that these flu symptoms are not caused

simply by the presence of a flu infection in the body. Symptoms experienced

are actually a result of your body*s immune system responding to the flu

infection via inflammation.

These unpleasant symptoms of inflammation are essential to getting over

the flu. Chills are your body*s way of telling you to bundle up and get

warmer, and the actual shaking involved with the chills is your body*s way of

increasing core body temperature through motion. After you*ve bundled up and

had the chills for a while, a fever results and your body uses the fever to

activate the immune system. A fever triggers a cascade of immune system

activities necessary to fight infection. Lack of appetite is your body telling

you that there isn*t enough energy to process food – all available energy

is fighting the infection. Muscle aches, soreness and inflammation are the

result of your immune system responding to the infection and your body

fighting back.

Without these symptoms present during the flu, your body would not be

fighting and you would not get over the common flu.

Because Lyme Disease is an infection, as the flu is, most symptoms

experienced by a Lyme Disease sufferer are the body*s response to the

infection.

The spirochetes themselves (their physical presence in the body) are not

responsible for the majority of symptoms in Lyme Disease.

As with the flu, symptoms of Lyme Disease are an indication that the body

is responding and fighting. Yet, curiously, even in some of the worst Lyme

Disease infections, symptoms can wax and wane, even with occasional

symptom-free periods. Some people report that when they were first infected with

Lyme Disease they were plagued with flu-like symptoms and even bedridden for

a while … and then things seem to get better, and their symptoms became

less intense. For example, many people with Lyme Disease are still able to

walk around, go to the movies, even work full or part time – all this while

they have a raging, active infection which is much more dangerous than the

flu. Lyme Disease sufferers often do not get fevers – sometimes are even

incapable of getting a fever. Considering that a fever is the body*s most

useful tool in fighting infection, this observation is also peculiar. The flu

involves intense, continual symptoms. Lyme Disease often does not.

Lack of debilitating symptoms, absence of fevers, and presence of

symptom-free periods may convince a person infected with Lyme Disease that they

aren*t really that sick. This is an understandable assumption because in most

illnesses lack of symptoms does indicate that you are on the mend.

The truth as it pertains to Lyme Disease is shocking. Lack of expected

symptoms indicates that the infection is actually winning – it is not gone!

The body fighting is what causes symptoms. So, if there are no symptoms,

there is no fight. The infection has free reign and the immune system is not

doing its job. Why does the human immune system fight the common flu but not

Lyme Disease?

 

 

What separates Lyme Disease from the flu is that the Lyme spirochete

tricks the immune system into living in harmony with the infection. The immune

system*s ability to identify Lyme Disease as a foreign invader is jammed and

disabled by the advanced infective activities of the bacteria.

The infection acclimatizes to the immune system.

Lyme Disease researchers have identified many specific strategies employed

by the Lyme Disease bacteria to accomplish this. One of the most creative

involves the spirochete concealing the part of its bacterial body

containing a protein code that tells your immune system it is an invader. Not

only

can it hide this code, it can change it quickly enough to stay ahead of the

immune system recognition process. This phenomenon is called

antigen-shifting. The flu virus cannot do this. Other methods of immune system

evasion

are beyond the scope of this book but can easily be found in other Lyme

Disease literature.

The result of the infection*s ability to evade the immune system is that

the bacteria can proliferate and grow for years without challenge from the

immune system.

Enter chronic Lyme Disease.

Although the bacteria are able to persist largely unchallenged, a person

will still experience symptoms of disease. People with chronic Lyme Disease,

although often not as acutely ill as people with the flu, are very sick.

In **stealth mode** the Lyme Disease spirochete secretes a neurotoxin that

is highly destructive to body functions and can result in stressed liver

detoxification, lethargy and fatigue, muscle soreness, mental confusion,

emotional instability, hypothalamus dysfunction, and much more. Hypothalamus

dysfunction eventually throws off the thyroid and adrenal glands and other

hormonal functions, which results in a cascade of dozens of other symptoms.

Additionally, because the spirochete’s evasion is not 100% successful, the

immune system may sometimes **catch a glimpse** of the infection,

resulting in symptoms of inflammation and immune system activation. A person

can

experience chills, headache, sore throat, nausea, fatigue, muscle aches,

enlarged spleen, cold extremities, etc. The most notable symptoms are typically

in the brain. The brain can become inflamed, as it would with any other

bacterial infection. Encephalopathy or meningitis may occur, along with very

scary brain symptoms including confusion, **Lyme rage,** depression,

memory loss, etc.

Based on this information, we can establish that the two primary causes of

symptoms in Lyme Disease are neurotoxin circulation (which persists

despite immune system acclimatization) and inflammation (which decreases as the

infection acclimatizes to the immune system). Let*s see how this relates to

herx reactions.

Understanding the herx reaction

Most Lyme Disease sufferers know of the Jarisch-Herxheimer reaction as a

**herx,** or **getting worse before you get better,** or a **healing

crisis.** The herx reaction is documented to take place in Syphilis, Lyme

Disease, and a few other spirochetal illnesses, all capable of evading the

immune

system. The reaction is named after two scientists who discovered the

phenomenon. Adolf Jarisch (1850-1902), was an Austrian dermatologist who

published his description of the reaction in 1895. Karl Herxheimer (1861-1944)

was

a German dermatologist who published his description of the reaction in

1902.

The definition of a herx reaction is an increase in the symptoms of a

spirochetal disease (such as Syphilis, Lyme Disease, or relapsing fever)

occurring in some persons when treatment with spirocheticidal therapy is

started.

In the case of Lyme Disease the herx reaction is an increase in the

symptoms caused by neurotoxin circulation and inflammation:

-- Increased neurotoxin circulation.

As you’ve seen, during normal lifecycle activities, the spirochete

secretes neurotoxins. However, when the spirochete is killed, an intense

release

of neurotoxins from dying bacterial organisms floods the body. Increased

neurotoxin circulation can last from a few hours to a few weeks, depending on

the sufficiency of a person’s detoxification pathways as well as the extent

of the kill-off.

 

 

-- Increased inflammation.

Whether using rife machines or antibiotics (or some other anti-Lyme

activity), spirochetes will become irritated or killed during the attack. Their

delicate, once-hidden antigens (protein codes which alert the immune system

to the presence of an invader) will be exposed as spirochetes die and their

bacterial proteins enter circulation. Suddenly the immune system will

detect multitudes of spirochetes infecting various locations of the body. The

immune system was unable to **see** the spirochetes before the kill off,

but when the infection does become visible, major immune system activation

begins. The body starts fighting during a herx reaction. So symptoms of

inflammation increase as they would in the flu. The reaction can vary from

person to person, depending on the extent of the infection, location of infected

areas, and body constitution. Although the inflammatory portion of the herx

response is unpleasant and involves greatly increased symptoms, it is a

sign that therapy was successful because spirochetes are dying and the immune

system is fighting. Lyme Disease cannot be eradicated if the immune system

is not activated.

 

 

The combination of the above two events constitute a herx reaction.

After anti-Lyme therapy is stopped and time passes, the herx reaction

slowly ends. The bacteria that were unaffected by treatment remain in the body,

largely undetected. These bacteria were not affected because they did not

happen to be in the spirochete portion of their lifecycle when the treatment

took place.

 

The stalemate between Lyme Disease and the immune system will continue

after a herx reaction. Only now, some progress has been made. The treatment,

in combination with a temporarily activated immune system, has killed some

bacteria. Bacterial load was reduced, and consequently the person will

experience a decrease in ongoing symptoms of inflammation and neurotoxin

circulation. The decrease in symptoms may be subtle because only a small

percentage of the bacterial load was effected.

 

 

(http://lymebook.com/blog/the-recovery-process/herx-reactions/herx-reaction-fund\

amentals/)

 

 

 

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