Curcumin and chronic fatigue syndrome

[Guest guest]

This does not pertain only to Chronic Fatigue Syndrome - but to all

conditions/issues where inflammation, oxidative stress, significant fatigue,.

hyperalgesia (increased sensitivity to pain), including muscular tension,

fatigue, irritability, depression, a subjective feeling of infection, and aches

and pain are isssues. blessings, Shan

 

 

Curcumin has been used safely as a culinary spice in Asia for centuries.

It is estimated that adults in India ingest 80-200 mg of curcumin daily.

 

Curcumin is also known as:

Tumeric, Curcuma longa, Indian saffron, Saffron, Curcuminoids

 

antioxidant

anti inflammation

anticoagulatant

 

 

~jvr

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(http://bit.ly/18FhQC) eXaminer.com

Deborah Mitchell

Phoenix Alternative Medicine Examiner

June 1

_http://bit.ly/18FhQC

_ (http://bit.ly/18FhQC)

 

Curcumin and chronic fatigue syndrome

 

 

Chronic fatigue syndrome affects millions of people in the United States,

making it virtually impossible for many of them to hold a full-time or

even

part-time job, go to school, enjoy their families, or participate in

routine or leisure activities. Estimates of the actual number of people who

have

the disease vary widely, from 500,000 to more than 4 million.

 

So far there is no cure, but experts are on the trail of several potential

treatments. Recent research is turning up promising information about

curcumin, an active component of the herb turmeric.

 

 

Study of curcumin and chronic fatigue

 

Oxidative stress is a significant factor in chronic fatigue syndrome, and

so ways to reduce it theoretically should also improve symptoms of this

complex condition.

 

 

A study published in the January 2009 issue of Immunobiology reports on

mice who were challenged with a stress test for 10 minutes daily for 19 days.

Half of the mice were given curcumin and the other half acted as controls.

 

 

The control mice showed signs of significant fatigue and had hyperalgesia

(increased sensitivity to pain), another common symptom of the syndrome.

 

The mice who were given curcumin showed a significant reduction in

fatigue, oxidative stress, and hyperalgesia.

 

 

The investigators suggest that curcumin may be a valuble option in the

treatment of chronic fatigue syndrome.

 

 

Curcumin in patients with chronic fatigue syndrome

 

Along with an increase in oxidative stress, research shows that chronic

fatigue syndrome is accompanied by activation of the inflammatory response

system, and that a natural agent called nuclear factor kappa

beta (NFkappabeta) is the main intracellular mechanism that regulates

inflammatory and oxidative stress mediators.

 

 

In a _Belgian study_

(http://www.ncbi.nlm.nih.gov/pubmed/17693979?ordinalpos=3 & itool=EntrezSystem2.PE\

ntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultRepo

rtPanel.Pubmed_RVDocSum) , researchers studied the possible impact of

inhibiting the production of NFkappabeta in patients who had chronic fatigue

syndrome.

 

They found that there were significant correlations between the production

of NFkappabeta and symptoms typically associated with the syndrome,

including muscular tension, fatigue, irritability, depression, a

subjective feeling of infection, and aches and pain.

 

 

They also discovered that the increase in oxidative stress and

inflammation reported in previous studies of chronic fatigue syndrome may be

caused by

increased production of NFkappabeta.

 

Given these results, the study’s authors suggest that people with chronic

fatigue syndrome should be treated with antioxidants that are known to

inhibit the production of NFkappabeta, including curcumin, quercetin, lipoic

acid, and omega-3 fatty acids.

 

 

Curcumin for chronic fatigue syndrome

 

 

Curcumin is one of several curcuminoids, the natural pigments that give

the spice turmeric its yellow color. It has both antioxidant and

anti-inflammatory properties, and as such it is also used to treat arthritis,

inflammatory bowel disease, and to help maintain a healthy cardiovascular

system.

 

 

The suggested dose of curcumin for chronic fatigue syndrome is 100 mg

daily of an enteric-coated supplement, or 900 to 1,800 mg of regular

supplements.

 

 

The reason for the enteric coating is that curcumin has low bioavailability

—the body does not readily absorb and assimilate it, because much of it is

changed in the stomach. Therefore, an enteric-coated supplement can help

ensure an adequate amount is utilized by the body.

 

 

If you take uncoated curcumin, it is suggested that you also take

piperine to enhance assimilation into the bloodstream. Some curcumin

supplements

have piperine (a black pepper derivative) added.

 

 

Although side effects associated with curcumin use are very rare, it

should not be used by women who are pregnant or breastfeeding. People who are

taking anticoagulants should talk to their doctor before taking curcumin.

Always talk to your health-care provider before starting any new supplement

program.

 

 

You can find curcumin supplements at many Phoenix-area stores and

pharmacies, including Sprouts Farmers Market, Healthy Habit Health Foods, and

the

Natural Medicinary.

 

 

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