CO-CURE: study of probiotic in emotional symptoms of chronic fatigue syndrome

[Guest guest]

Sun, 5 Apr 2009 13:55:50 +0100

Tom Kindlon <_tomkindlon_

(tomkindlon) >

RES: A randomized, double-blind, placebo-controlled pilot study of

a probiotic in emotional symptoms of chronic fatigue syndrome

 

A randomized, double-blind, placebo-controlled pilot study of a probiotic in

emotional symptoms of chronic fatigue syndrome.

 

Gut Pathog. 2009 Mar 19;1(1):6.

 

Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM, Logan AC.

Integrative Care Centre of Toronto, 3600 Ellesmere Road, Unit 4, Toronto,

Ontario M1C 4Y8, Canada. _aclnd_ (aclnd) .

 

ABSTRACT:

Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among

the broad range of symptoms, many patients report disturbances in the

emotional realm, the most frequent of which is anxiety. Research shows that

patients with CFS and other so-called functional somatic disorders have

alterations

in the intestinal microbial flora. Emerging studies have suggested that

pathogenic and non-pathogenic gut bacteria might influence mood-related

symptoms

and even behavior in animals and humans. In this pilot study, 39 CFS patients

were randomized to receive either 24 billion colony forming units of

Lactobacillus casei strain Shirota (LcS) or a placebo daily for two months.

Patients

provided stool samples and completed the Beck Depression and Beck Anxiety

Inventories before and after the intervention. We found a significant rise in

both Lactobacillus and Bifidobacteria in those taking the LcS, and there was

also a significant decrease in anxiety symptoms among those taking the

probiotic vs controls (p = 0.01). These results lend further support to the

presence

of a gut-brain interface, one that may be mediated by microbes that reside or

pass through the intestinal tract.

 

PMID: 19338686 [PubMed - in process]

 

Free full text at: _http://www.gutpathogens.com/content/1/1/6_

(http://www.gutpathogens.com/content/1/1/6)

 

===============

Note: This paper used the Carruthers 2003 (aka Canadian) diagnostic

criteria: " Those adult patients aged 18-65 meeting the formal diagnostic

criteria for

CFS, according to published guidelines, [13] "

 

13. Carruthers BM, Jain AK, De Meirleir KL, Peterson DL, Klimas NG, Lerner

AM, et al.: Myalgic encephalomyelitis/chronic fatigue syndrome: Clinical

working case definition, diagnostic and treatment protocols. J Chronic Fatigue

Syndrome 2003, 11:7-115.

 

------------

Send posts to _CO-CURE_

(CO-CURE)

Un at _http://www.co-cure.org/unsub.htm_

(http://www.co-cure.org/unsub.htm)

Co-Cure Archives: _http://listserv.nodak.edu/archives/co-cure.html_

(http://listserv.nodak.edu/archives/co-cure.html)

------------

Co-Cure's purpose is to provide information from across the spectrum of

opinion concerning medical, research and political aspects of ME/CFS and/or

FMS.

We take no position on the validity of any specific scientific or political

opinion expressed in Co-Cure posts, and we urge readers to research the

various opinions available before assuming any one interpretation is

definitive.

The Co-Cure website <_www.co-cure.org_ (http://www.co-cure.org) > has a link

to our complete archive of posts as well as articles of central importance to

the issues of our community.

------------

 

(http://www.papercut.biz/emailStripper.htm)