From Dr Martin Pall about MCS & The NO/ONOO Cycle & Treatment

[Guest guest]

from a group run by Dr. Martin Pall. In the last sentence of the text he

says that it is OK to forward this info.

 

**The NO/ONOO- cycle has been recognized in many extraordinary ways over the

past several months, such that it should be viewed as THE predominant model

of this previously unexplained disease. I was invited to give the initial

address at the European Environmental Medicine meeting in Wurzburg, a two day

meeting that was largely dominated by the NO/ONOO- cycle mechanism. This was

part of a *grand European tour*, giving seven talks in five countries. These

included being the only non-European invited to address the European Union

Parliament (The Council of Nations) at a special meeting on Environmental

Medicine. There were also two special mini-symposia organized to correspond to

my

visit in Europe, another great honor. I gave talks in Italy, Germany, Austria,

Switzerland and France, including talks at three medical schools. So there

has been extraordinary recognition of the NO/ONOO- cycle mechanism, a mechanism

tha! t is helping people in many countries around the world to actually

lessen their chemical sensitivity responses. I might add that there was a book

written in German on multiple chemical sensitivity, with Hans-Ulrich Hill as

first author, that is largely focussed on the NO/ONOO- cycle mechanism of MCS.

 

While these are all extraordinary recognition for this science, the most

important recognition is elsewhere. I have been asked to write a review on MCS,

to be a chapter in a very prestigious multivolume set on toxicology, and that

review has been accepted and will be coming out this coming autumn. This is

extraordinarily important for at least four distinct reasons.

- The first, of course is that MCS has been largely ignored by the

toxicologists, despite its high prevalence in the U.S. and in other populations

because they have felt that there was no reasonable explanation for it. Now,

clearly, they find that we now do have a compelling and well-supported

explanation

for MCS and therefore it should be integrated into the larger framework of

toxicology.

- Secondly, the fact that they asked me to write this review is obviously

extraordinary recognition for my own work in developing, for the first time,

this detailed and well-supported mechanism, as well as for the mechanism

itself.

- Thirdly, this review is the longest such review on MCS ever written, as

well as the most extensively documented, having well over 400 citations in it.

- Fourthly, there are several very important types of evidence that were new

to me, supporting the NO/ONOO- cycle mechanism that are reviewed in this

chapter, including important studies of the mechanism of toxic action of the

seven groups of chemicals implicated in MCS, including important animal model

studies of MCS implicating almost all of the NO/ONOO- cycle elements and

including a series of published studies of various objectively measurable

responses

to low level chemical exposure, responses that are consistent with the

NO/ONOO- cycle and that should be developed as specific biomarker tests for MCS.

 

When this paper comes out, we as a community concerned about the suffering

of the millions of people who are chemically sensitive, will have a unique

opportunity to dramatically change the views of the general public, the news

media and even the court system of this horrible world-wide epidemic. That

opportunity will come because of the essential juxtaposition of rigorous science

and extraordinary recognition. You are welcome to forward this as you wish.**

 

- by Martin L. Pall

 

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