OZONE-THERAPY IN MULTIPE SCLEROSIS - FIRST OBSERVATIONS

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OZONE-THERAPY IN MULTIPLE SCLEROSIS: FIRST OBSERVATIONS

 

 

Authors: V.Simonetti, A. Rutigliano, W. Liboni, P. Biancotti, K.Strumia, M.

Simonetti

Corrispondence to Dr. Vincenzo Simonetti

ABSTRACT

Authors explain the rational that induced them to use ozone-therapy in

multiple sclerosis. First clinical observations about 23 patients (n=23)

treated

with ozone, seem to encourage the application of ozonized autoemotransfusion

with other patients.

After six years the authors verified that 13 patients afflicted with

autoimmune pathologies (10 multiple sclerosis and 3 rheumatoid arthritis)

continually treated with ozone, the lymphocytary subpopulation stabilized in

limits of

reference interval: level of T lymphocyte " helper/inducer " stabilized during

these years and the level of T lymphocyte (CD3+, HLA-, DR+) didn't increase.

ARTICLE

Ozone-therapy is used for many years with large successes, attained with

orthopaedic [3, 4, 6, 10]nd vascular [1, 2,3, 5, 8, 11, 13] pathologies. For

these pathologies, if treated, it was widely described the anti-inflammatory,

antalgic, antibacterial and virustatic [3, 4, 6, 10, 13, 14] effect,

perfusional improvement of microcirculatory system [1, 2, 3, 5,8, 11, 13] then

the

consequent disappearance of ischemic pain, the functional recovery of that

muscul-articular cluster previously compromise and/or the recovery of diabetic

ulcers: these effects significantly help to improve the quality of life of the

patients, to return very effective many pharmacological or rehabilitation

therapies, to shield some iatrogenic damages too.

The perfusional improvement of microcirculatory system allows a better use

of oxygen and of glucoses, stimulates the metabolic activation and the

elimination of catabolites, it's accumulation contributes to determine the

inflammatory [3, 6, 8, 10]. In diabetic insulin-dependents patients, treated

with

GAET (great autoemotransfusion), we had often reduce the therapeutic dosages of

insulin.

With subcutaneous or intramuscular injections of O2/O3, we observed the

sudden disappearance of muscle-contraction headache, in tendonitis, in

arthropaty, in trigeminal neuralgia; the significative reduction of lymphedema

in

rheumatoid arthritis, in erysipelas, in edemato-fibrosclerotic and

post-traumatic

panniculitis; while with therapeutic firmer cycles, we obtain great

successes in treatment of backaches and repair of nervous peripheral lesions on

trigeminus, on SPE, on ramus sensitive/motor consequent to operation of

herniated

disk, carpal tunnel syndrome, mixed tumor of parotid.

We and others ozone-therapists colleagues observed, after GAET great

clinical improvements, such to reduce or to suspend cortisones and FANS in

patients

afflicted with rheumatoid arthritis; clinical healing for recurrent or

several herpetic infections; a great improvement in asthmatic pathology, such

to

permit a reduction or a suspension of previous therapy used from many years.

Many ozone-therapists could observe favourable effects both in cases of

immunodepression and in cases of patients afflicted with autoimmune

pathologies.

We published a work about immuno-modulator effect of ozone in lymphocyte

subpopulation [13]. In 1998 we valued the changes on lymphocyte subpopulation

with 38 patients afflicted with various pathologies.

Image 1

After six years we verified with 13 patients afflicted with autoimmune

pathologies (10 multiple sclerosis, 3 rheumatoid arthritis) with their therapy,

if

a long-time treatment of ozone could determine some variations, in

particular on HLA-DR+ moiety. Lymphocyte subpopulations in treated patients,

resulted

stable in limits of reference interval. Particular interesting resulted the

informations about T lymphocyte " helper/inducer " (subpopulation CD4+) it

level is a gauge of an adequate immunity competence and is a constant result;

the

T lymphocyte (subpopulation CD3+HLA-DR+) that didn't increase.

J. Socrates Bardi of " The Scripts Institute " recently demonstrated IgG have

a bactericide action while they are releasing O3 by nature. [14]

The chief Bocci, Portolano, Sammartino and Luongo furnished documentary

evidence for ozone, that with adequate dose, doesn't seem to unwanted effects,

but it induces the activation of enzymes delegated to inactivation of free

radicals (catalase, superoxide-dismutasis, glutathione…) [3,6] and of

disulfide

points that are forming during the growth and during the metabolism in aerobic

conditions, with consequent curative proteic action.

The chief Riva Sanseverino [8] demonstrated the good effect of ozone therapy

on macular circle in 1990. Dr. G. Amato showed that ozone has more

hemorrhagic properties than pentoxifylline.

The researches done by chief Amato, Berté, Bocci, Iliakis, Lettieri, Luongo,

Portolano, Raso, Riva Sanseverino, Rokitanski, Sammartino, Valdenassi…

showed us that GAET has a immune modulate effect and it can induce the

circulation

reactivation: these studies were done to stimulate us to try oxygen ozone

therapy also with neurodegenerative diseases, with autoimmune neurological

pathologies and with cerebral vascular lesions, whether post trauma or post

thrombotic ictus or due to haemorrhage [1,2,3,4,5,6,7,8,9,10,11]

Why does ozone reduce muscular overtone? Does ozone act to neuronal level

and/or with fibromyocell?

Doing great autoemotrasfusion, the positive effect just described are slower

than doing local injections on tendon's insertion; but while local injection

has just local effects, the effect of GAET are more general for the body,

and the GAET gives a sensation of more well-being, more resistance to effort.

For these reason we do the GAET with immune and vascular pathologies. These

successful results of ozone therapy, obtained by or many colleagues and

confirmed from us directly, moreover the verified absence of important side

effect,

often present with the various schemes of pharmacologic therapy, make us to

try the ozone therapy with patients with MS: the autoimmune etiology, the

spastic and painful semiotics, the often presence of asthenia and lymphedema,

are for us a good purpose to apply ozone therapy.

Until now we had 23 patient with informed consent, giving like end point:

- Reduction of pain due to spasticity and/or postural alteration

- Improvement of watch-sleep rhythm

- Functional improvement of venous lymphatic microcirculation, compromised

by alteration of neurovegetative and postural regulation

- Improvement of neurovegetative and sphincter function

- Watching the evolution and remission's time of symptoms due to seriousness

of pathology of inflamed lesions of cerebral and medullar parenchyma

- Slowing down of pathology progression

- Improvement of kinaesthesia

The clinical observations of 23 patients, let us observe that the usual

disability lists (FIM Ashwort…) don't contemplate enough steps to underline

ozone

therapy effect, that, anyway, improve so much life's quality of patients.

Our clinic result are in line with starting task.

METHOD

GAET 240ml of blood with 55 µg of ozone for 20 times, twice a week and a

periodical recall every 2-3 month, it depends of seriousness of pathology

CLINIC CASE

Patient 30 y.o. with MS since 1996 with paresthesia of superior and lower

extremity, with dysesthesia of dexter emisome. The protocol of GAET was

practised (240 of blood with 55 µg of ozone for 2 months). In these 6 years

the

patient recovered the symtomatology and he is clinically stable with a regular

social working life: the paraesthesia of superior and lower left extremity

disappeared, the facial left deficit and the dysesthesia of dexter emisome too.

It persist a disappeared paraesthesia on left knee. We observed radiogically

a sharp decrease of focus active previously.

Image 2

Image 3

CONCLUSION

The ozone therapy doesn't resolves basis pathology, but also it is a valid

therapy in multiple sclerosis, where it can improve the quality of life,

without serious collateral effects, especially in patients that can't submit

themselves to pharmacological treatment. This improvement reveal itself

clinically

with a recovery more or less evidently in ratio of seriousness and

chronicity of the pathological reached state

BIBLIOGRAPHY

[1] G. Amato: Impiego Ospedaliero-sezione scientifica 1992 " Valutazione

dellefficacia dell'ozonoterapia nel trattamento delle flebopatie degli arti

inferiori " .

[2] G. Amato: Acta Toxic. Ther., vol XVII,n°2-3,1996, " Valutazione

dell'efficacia dell'ozonoterapia nelle arteriopatie croniche ostruttive degli

arti

inferiori: Confronto con la terapia con Pentossifillina " .

[3] Bocci: Acta Toxic.Ther., vol XVII, n°2-3,1996 " Verso una

razionalizzazione dell'ozonoterapia " .

[4] E. Iliakis: " Acta Toxic.,Ther.,vol XVII,n° 2-3, 1996 " Utilizzo

dell'ossigeno-ozonoterapia nella pratica ortopedica " .

[5] Lettieri: Acta Toxic.,Ther., vol XVII,n° 2-3,1996 " Efficacia

dell'ozonoterapia nella prevenzione della recidiva dell'infarto miocardico " .

[6] Portolano-Sammartino: Acta Toxic.,Ther., vol XVII, n°2-3,

1996, " Biochimica e fisiologia dell'ozono " .

[7] A. Raso Ed. Minerva Medica 1990: " Manuale di medicina e chirurgia

vascolare " .

[8] Riva Sanseverino: Panminerva Medica, vol.32,n°2,1990, " Effects of

oxygen-ozontherapy on agerelated degenerative retinal maculopaty " .

[9] Rokitansky : Atti II congresso nazionale di ossigeno-ozonoterapia -

Bergamo 19/10/85, " Ossigeno-ozonoterapia nelle arteriopatie " .

[10] Sammartino-Luongo : Acta Toxic.,Ther., vol XVII., n° 2-3,1996,

" Monitoraggio dei parametri bioumorali negli epatopatici cronici trattati con

ozonoterapia " .

[11] Valdenassi, Richelmi, Franzini: Flebologia, anno 1995, n°

2, " L'ossigeno-ozonoterapia nell'insufficienza venosa cronica: studio clinico di

efficacia

e tollerabilità " .

[12] Jurg Kesserling: " Multiple Sclerosis " , Cambridge University Press 1997

[13] Simonetti V, Liboni W, Biancotti P, Grillo A: " La malattia ischemici

periferica " , Manusia F, Tip Aurelia, Novembre 2001

[14] Jason Socrates Bardi: News and Views; The Scripps Research Institute,

" More Chemical Evidence for an Antibody Killing Mechanism "

Image 1: The test evidences the increase of ratio CD4+/CD8+ and the

stability of the lymphocitary subpopulation CD3+ HLA DR+

 

Image 2

 

 

 

Image 3: After 6 years, the patient is clinically stable, without changes of

hyperintense signal in C5 with slight atrophic parenchymal image. For

sensitive disorder persists a feeble formication, a disappeared paraesthesia on

lateral side of left knee.

 

 

 

 

 

 

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