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Variance in chemical exposure tolerance

_http://findarticles.com/p/articles/mi_m0ISW/is_/ai_n15341116_

(http://findarticles.com/p/articles/mi_m0ISW/is_/ai_n15341116)

Townsend Letter for Doctors and Patients, August-Sept, 2005

by Don Richard Paladin

 

In 2002 I wrote an article trying to help explain why one person may have a

low tolerance for a chemical and others may not. (1) Very recent research

from Canada may demonstrate a relationship between deficiencies of enzymes and

chemical intolerance. (2) I would highly recommend that The American Academy

of Family Physicians, The American Medical Association, and others review

their position on Environmental Intolerance (Multiple Chemical Sensitivity).

There is much literature sponsored by advocates for industry that attempts to

minimize the consequences of synthetic toxic chemicals by suggesting that those

who report symptoms from these chemicals have psychosomatic disorders. (3,4)

There are likely relationships between environmental triggers and

psychological as well as other symptoms. Symptoms, however, are not causes.

 

Dr. Robert Haley has reported a relationship between Gulf War Syndrome and a

deficiency of the enzyme serum paraoxonase (Pon-Q) that detoxifies

organophosphates. He has concluded that a deficiency of this enzyme can explain

why

one soldier may tolerate a higher dose of an organophosphate exposure and

another may be damaged and become ill. (5)

 

A recent report in the New York Times explains, " Citing new scientific

research on the effects of exposure to low levels of neurotoxins, the Research

Advisory Committee on Gulf War Veterans' Illnesses concludes in its draft

report

that " a substantial proportion of Gulf War veterans are ill with

multisymptom conditions not explained by wartime stress or psychiatric illness.

A

growing body of research suggests that many veterans' symptoms have a

neurological

cause and that there is a " probable link " to exposure to neurotoxins. " (6)

 

Recent research by Ella H. Sklan et al. may help explain the Panic Attack

and anxiety connection to exposures to stimuli that may be toxic (like

pesticides). " Serum AChE and PON enzyme activities were both found to be

affected by

demographic parameters, and showed inverse, reciprocal associations with

anxiety measures. " (7)

 

If one has a much lower level than normal of the enzymes involved in

detoxification of any given stimuli (Pon-Q and organophosphates are the example

I am

using), then one will have a lower tolerance to the stimuli. It is

interesting that a lower level of PON-Q and AChE may also be implicated in the

precipitation of anxiety. This suggests the lower level of enzymes and other

biochemicals may be responsible for symptoms of anxiety and panic disorders.

 

It is time we move away from a psychological explanation of the cause of

chemical intolerance and try to understand the rudimentary biochemistry behind

the illness. Not only will this information help those with antibody mediated

allergies but also greatly help those with intolerances to environmental

stimuli.

 

Since MCS (Chemical Intolerance, Environmental Intolerance) is not an

antibody mediated allergy, I believe allergy specialists and others should

acknowledge they do not understand the mechanism of the disorder and quit

trying to

discount it with a " psychogenic " canard. I am sure that anyone with any

knowledge of medical history knows that both antibody mediated allergies and

asthma

were once considered to be psychosomatic. There is a great deal we don't

understand. A little humility by the allopathic medical community would go a

long way.

 

There is now research from Japan in which they conclude: " MCS patients do

not have either somatic or psychologic symptoms under chemical-free conditions,

and symptoms may be provoked only when exposed to chemicals. " (8)

 

Don Richard Paladin

Bellingham, Washington USA

_Sunergos_ (Sunergos)

 

 

References

 

1. Understanding Chemical Intolerance, an investigation by Don Richard

Paladin, _http://wsmcsn.s5.com/understandci.htm_

(http://wsmcsn.s5.com/understandci.htm)

 

2. Gail McKeown-Eyssen, Cornelia Baines, David E. C. Cole, Nicole Riley,

Rachel F. Tyndale, Casecontrol study of genotypes in multiple chemical

sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR, International Journal of

Epidemiology, doi:10.1093/ije/dyh251,

_http://ije.oupjournals.org/cgi/content/abstract/dyh251v1_

(http://ije.oupjournals.org/cgi/content/abstract/dyh251v1)

 

3. Multiple Chemical Sensitivity Under Siege by Ann MacCampbell, MD,

Townsend Letter for Doctors & Patients, January 2001, #210, p. 20-27 at

_http://www.tldp.com/issue/210/mcsundersi.htm_

(http://www.tldp.com/issue/210/mcsundersi.htm) in which she writes. " When

confronted by the harm they have caused,

corporations typically blame the victims, deny the problem, and try to avoid

responsibility for the harm caused. The corporate response to MCS has been no

different. "

 

4. The Chemical Manufacturers Association's Environmental Illness Briefing

Paper, 1990 in which they state: " Because it has the potential to impact many

segments of society, many groups have an interest in placing environmental

Illness in its proper perspective.... Because environmental illness is a health

issue, the only people who can legitimize it are physicians, and they have

not. Should environmental illness arise as an issue, a coalition with the

state medical association is absolutely necessary. "

_http://users.lmi.net/~wilworks/books/cmaeibri.htm_

(http://users.lmi.net/~wilworks/books/cmaeibri.htm)

 

5. The University of Texas Southwestern Medical Center at Dallas, UT

Southwestern researcher finds genetic cause for Gulf War syndrome,

_http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=144_

(http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=144)

 

6. Shane, Scott, Chemicals Sickened '91 Gulf War Veterans, Latest Study

Finds, The New York Times, October 15, 2004

_http://www.nytimes.com/2004/10/15/politics/15gulf.html?oref=login & oref=login & or\

ef=login & ei=5094 & en=0f74f8004623b4bf &

hp= & ex=1097812800 & partner_

(http://www.nytimes.com/2004/10/15/politics/15gulf.html?oref=login & oref=login & or\

ef=login & ei=5094 & en=0f74f8004623b4bf & hp= & ex=10978

12800 & partner)

 

7. Ella H. Sklan, Alexander Lowenthal, Mira Korner, Ya'acov Ritov, Daniel M.

Landers, Tuomo Rankinen, Claude Bouchard, Arthur S. Leon, Treva Rice, D.C.

Rao, Jack H. Wilmore, James S. Skinner and Hermona Soreq,

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores

in Health, Risk

Factors, Exercise Training, and Genetics Study Biochemistry, April 13, 2004 |

vol. 101 | no. 15 | 5512-5517. _http://www.pnas.org/cgi/content_

(http://www.pnas.org/cgi/content)

 

8. Saito M, Kumano H, Yoshiuchi K, Kokubo N, Ohashi K, Yamamoto Y, Shinohara

N, Yanagisawa Y, Sakabe K, Miyata M, Ishikawa S, Kuboki T.; Psychosom Med.

2005 Mar-Apr;67(2):318-25,

_http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstr\

act & list_uids=15784800_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstr\

act & list_uids=15784800)

 

 

 

COPYRIGHT 2005 The Townsend Letter Group COPYRIGHT 2005 Gale Group

 

Don Richard Paladin " Variance in chemical exposure tolerance " .

Townsend Letter for Doctors and Patients. 27 Sep. 2008.

_http://findarticles.com/p/articles/mi_m0ISW/is_265-266/ai_n15341116_

(http://findarticles.com/p/articles/mi_m0ISW/is_265-266/ai_n15341116)

 

(http://www.papercut.biz/emailStripper.htm)

 

(http://www.papercut.biz/emailStripper.htm)

 

 

 

 

 

 

 

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