UCLA Curcumin Alzheimer's Breakthrough?

[Guest guest]

I know that curcumin's limitations for viable treatment is

bioavailability. In humans they havent achieved more than 0.1uM free

curcumin in plasma even with piperine at like 12 grams per day, but

here they report 5uM, like 50x greater. Could this be true? See

http://www.ncbi.nlm.nih.gov/pubmed/18417733

 

" Oral gavage of an optimized lipidated curcumin formulation (Verdure

Sciences, Noblesville, Indiana) resulted in 11-fold higher levels of

curcumin in plasma and 4-fold higher levels in brain compared to

equal doses of curcumin powder or curcumin-piperine extracts. A 5 mg

curcumin dose delivered by acute gavage in this lipid rich

formulation (n=5) resulted in 2.15 ± 0.744 µM mouse brain curcumin

levels after 3 hrs. After 2 weeks lipidated formulation at 500 ppm

curcumin in chow (n=5) we observed 5.79 ± 1.22 µM mouse brain

curcumin, well above the 1-2 µM range of EC50's for the inhibition of

iNOS, IL-1ß, PGE2 and isoprostanes. This suggests oral delivery can

achieve our target tissue levels. "

 

http://www.ncbi.nlm.nih.gov/pubmed/18417733

 

Am I reading this right?

 

Curtis

 

" Anyone who has never made a mistake has never tried anything new. " -

Einstein

[Guest guest]

Curtis,

 

I am not a scientist so had a hard time reading the link, etc. Is

this on the market? Also, how would eating the actual turmeric root

work?

 

Thanks

GB

 

, " curtsummerlin "

<curtsummerlin wrote:

>

> I know that curcumin's limitations for viable treatment is

> bioavailability. In humans they havent achieved more than 0.1uM

free

> curcumin in plasma even with piperine at like 12 grams per day, but

> here they report 5uM, like 50x greater. Could this be true? See

> http://www.ncbi.nlm.nih.gov/pubmed/18417733

>

> " Oral gavage of an optimized lipidated curcumin formulation

(Verdure

> Sciences, Noblesville, Indiana) resulted in 11-fold higher levels

of

> curcumin in plasma and 4-fold higher levels in brain compared to

> equal doses of curcumin powder or curcumin-piperine extracts. A 5

mg

> curcumin dose delivered by acute gavage in this lipid rich

> formulation (n=5) resulted in 2.15 ± 0.744 µM mouse brain curcumin

> levels after 3 hrs. After 2 weeks lipidated formulation at 500 ppm

> curcumin in chow (n=5) we observed 5.79 ± 1.22 µM mouse brain

> curcumin, well above the 1-2 µM range of EC50's for the inhibition

of

> iNOS, IL-1ß, PGE2 and isoprostanes. This suggests oral delivery can

> achieve our target tissue levels. "

>

> http://www.ncbi.nlm.nih.gov/pubmed/18417733

>

> Am I reading this right?

>

> Curtis

>

> " Anyone who has never made a mistake has never tried anything new. "

-

> Einstein

>

[Guest guest]

Okay, I am completely clueless as to what you are talking about but am extremely

interested.  Are you saying that tumeric root can help or cure alzheimers?  Can

you put this in layman's terms for me.

 

Thanks;

Beva

 

 

 

 

 

 

 

 

[Guest guest]

Beva

 

Turmeric is good for a lot of things. Evidently scientists at UCLA

have come up with a process that makes turmeric much more effective

for Alzheimer's than the usual form of turmeric. I presume that

they used a form similiar to what most people buy commercially. That

is why I wrote Mr. Ebersole. It is in scientific terms and I think

that the only ones who really know about it are the scientists

because of the language.

 

GB

 

, Beva

<beva1960 wrote:

>

> Okay, I am completely clueless as to what you are talking about but

am extremely interested.  Are you saying that tumeric root can help

or cure alzheimers?  Can you put this in layman's terms for me.

>  

> Thanks;

> Beva

>