Anti-Ageing Discoveries

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Anti-Ageing Discoveries

_http://www.newmediaexplorer.org/chris/2003/07/26/antiageing_discoveries.htm_

(http://www.newmediaexplorer.org/chris/2003/07/26/antiageing_discoveries.htm)

 

Here is more proof why fresh unadulterated foods are so important, given

that: " Plant hormone KINETIN delays the onset of many cellular and biochemical

characteristics associated with cellular ageing of cultured human cells... "

Natural sources of kinetin related cytokinins are: very high levels in

coconut water/milk; all germinating seeds and growing tips etc. "

Of course as the note says below, if kinetin is to be marketed, it will have

to be modified so that it can be patented to fill the pharma pockets... as

far as I am concerned this is very sad. One should have a healthy concern

regarding patented nutrients, as these have no history and are hard to test

before marketing.

It's best to change and stick to _fresh wholesome foods _

(http://www.newmediaexplorer.org/chris/2003/07/25/fatty_rubbish_and_filth_in_flo\

ur.htm) as I have

so often stated.

Chris Gupta

Message #2827 included an article from the USENET bionet.molbio.ageing

news group on new " Anti-Ageing Discoveries " .

Here is the news of the second anti-ageing discovery. Plant hormone KINETIN

delays the onset of many cellular and biochemical characteristics associated

with cellular ageing of cultured human cells. Although kinetin and other

cytokinins are well known to have anti-ageing effects in plants, in human cells

it is the first time any such effects have been observed. Some of the main

effects by using the Hayflick system of human fibroblast ageing are:

- maintaining the youthful morphology for much longer period (up to 95%

lifespan completed)

- reversing senescent morphology.

- maintaining youthful cytoskeletal organization.

- maintaining youthful pattern of DNA, RNA and protein synthesis.

- slowing down the rate of accumulation of age-pigment like things.

These effects can be best seen as " preventive " effects instead of reversion

of ageing. Cells grown continuously stay younger. Most importantly, these

effects are achieved without interfering with the maximum proliferative

capacity. No additonal cell divisions are induced. This is unlike all other

anti-ageing things reported for cell cultures for example, FGF, PDGF, ginseng,

or the

latest I reported last week, carnosine. All those things induce additional

cell divisions which can be potentially harmful in terms of making cells move

on a path to immortalization (here meaning cancer.)

Kinetin is N6-furfunyadenine, a modified base that can get incorporated in

tRNA. It is a synthetic cytokinin. Its nearest natural relative is zeatin, but

in our experiments Kinetin is the most effective. All future research and

development is now in the hands of Procter & Gamble who got all rights from the

company SENETEK who had financed my research originally. Don't worry I have

not made any money from it. I am still struggling for long-term secure job.

Now come all those important mechanistic questions. How does it work? Where

does it go in a cell? What other applications and why? I have no answers yet.

We have been struggling to do these experiments but no one has given us

money for that. Commercial motto is: If it sells, it works or if it works it

sells. Not very interesting to know how?

Still we have some information on the kinetics of uptake, accumulation and

release of kinetin by human cells. Your suggestions on its mechanistic search

will be welcome.

A small free-base, modified a little, having such dramatic effects!!!!

Various other modifications do not have similar effects, or may be very small

effects. Also, it has to be free-base and not the nucleoside or neucleotide.

Apparently, in plants it does not matter, but in human cells it can be a

difference of life and death.

Natural sources of kinetin related cytokinins are: very high levels in coc

onut water/milk; all germinating seeds and growing tips etc.

Potential usages as nutritional supplement, anti-oxidative compounds, and

rejuvenator.

The paper: Kinetin delays the onset of ageing characteristics in human

fibroblasts, by SIS Rattan & BFC Clark is in Biochemical Biophysical Research

Communications, vol 201, pages not sure, 1994.

--

Fri, 24 Jun 1994 21:57:33 GMT

Newsgroups: bionet.molbio.ageing

Re: Anti-ageing discoveries

Distribution: bionet