The Cure For Keloids Old and New

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The Cure For Keloids Old and New

By William Wong, ND, PhD Member World Sports Medicine Hall of Fame.

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When a patient goes in for elective plastic surgery, it is most often with

the thought that they are improving something about their appearance. The

physician keeps aesthetics and symmetry in mind as the work is planned and done

much as a sculptor takes care to carve his artwork.

 

In serious injury when a fracture is compounded and sections of broken bone

tears through the skin, great care must be taken not only in reducing the

fracture but also in making sure no nerve damage has been done by the break or

created in the reduction. The ends of bone are carefully placed back where

they can mend and the skin closed and sutured to insure that it all heals.

Ofttimes in car accidents facial lacerations occur from flying shards of

glass. If the ER doctor is skilled at closing such wounds he will first suture

the gallia, the fine connective tissue layer beneath the skin, mating the ends

correctly then carefully closing the skin over that.

What happens after the events described above or any other injury or

surgical wound where skin and the connective tissue layers beneath are involved

hopefully is healing without scaring and without the formations of keloids.

What

are keloids? They are hard often unsightly mounds of connective tissue

bunched up and over grown; they are a form of fibrosis / scar tissue.

Fibrosis is the result of inflammation. Inflammation caused by the injury,

by the surgery, by a burn, whatever the cause inflammation is one of two

things that drive the growth of fibrosis. (The other cause of fibrosis growth

is

estrogen but that is not an operational factor in keloid formation. Long term

or intense inflammation is the spark that causes the formation of these

mounds of scar tissue). If the inflammation can be brought under control the

keloid formation might be arrested. Plastic surgeons routinely have

administered

local injections of cortisone in attempts to slow down the inflammation and

stop the formation of keloids. These attempts are mostly failures and if

pronounced the keloid itself may have to be surgically excised, which may in

turn

begin the round of keloid formation all over again.

It has been taught that a keloid older than a year will remain untreatable

regardless of what is done short of surgery. This line of thinking does not

hold world wide. Physicians in Central Europe and Japan have for decades been

treating various types of fibrosis, from post operative scar tissue, to renal

fibrosis, to pulmonary fibrosis with blends of orally administered

proteolytic enzymes specifically formulated to be absorbed and act

systemically.

(1,2,3,4,5.6). To date there are over 200 peer reviewed studies verifying both

the

absorption and therapeutic action of such enzymes. (See

_www.enzymescience.com_ (http://www.enzymescience.com) in the abstracts

archive).

In Germany the use of systemic enzymes is standard in the post operative

prevention of scar tissue, where the enzymes also decrease inflammation

(without

the side reactions or toxicity of the NSAID’s or steroids), and speed the

healing of tissue. It was surmised by some surgeons that if the enzymes could

prevent the formation of post operative scar tissue and existing fibrosis in

other conditions, that they could also lyse away the fibrosis of keloids.

Their assumption was correct.

While no formal studies have yet been done on keloids specifically, the

lysing action of the enzymes on other types of fibrosis has been studied and

noted. Various plastic surgeons have reported the removal of long standing

keloids from their patients. One interesting observation on the fibrosis lysing

effect of systemic enzymes came from a plastic surgeon from California. This

physician, while using a multi-enzyme product to reduce both the inflammation

and post operative scar tissue in his patients, was taking the product himself

to lower visceral inflammation levels and bring down CRP and Homocystine

levels. After several weeks on the product he reported that a 40 year old

keloid

the size of a small egg that had grown on his left hand, as the result of a

compound fracture, had been completely lysed away! Various other plastic

surgeons report the removal of long standing keloids from patients.

Up to now there has been no sure treatment for the prevention or elimination

of keloids. With the use of Systemic Enzymes, there is now a powerful,

effective, yet completely safe and non toxic tool for the treatment of this

form

of fibrosis. The effect of enzymes is dose dependent and results may be seen

seen in weeks or some months depending on the size of and circulation to the

keloid.

 

 

1) Transport of Proteolytic Enzymes Across Caco-2 Cell Monolayers

Bock U.,1 Kolac C.,1 Borchard G.,1 KochK.,1 Fuchs R.,1 Streichhan P.,2 and

Lehr C.-M.1

1 Department of Biopharmaceutics and Pharmaceutical Technology, University

of Saarland, Saarbrücken, Germany

2 Mucos Pharma GmbH, Geretsried, Germany

Pharmaceutical Research 1998, Vol. 15, No. 9, pp. 1393-1400.

2) Intestinal absorption of serrapeptase (TSP) in rats.

Moriya N, Nakata M, Nakamura M, Takaoka M, Iwasa S, Kato K, Kakinuma A.

Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1):101-8.

Biotechnology Research Laboratories, Takeda Chemical Industries Ltd., Osaka,

Japan.

3) Evaluation of Serratia peptidase in acute or chronic inflammation of

otorhinolaryngology pathology: a multicentre, double-blind, randomized trial

versus placebo.

Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E,

Vesperini G.

J Int Med Res. 1990 Sep-Oct;18(5):379-88.

Institute of Clinical Otorhinolaryngology, University of Naples, Italy.

4) Anti-inflammatory and analgesic activity of ExCLzyme-EN®

S.L.Bodhankar, A.U.Burhan, V.M.Kale, S.Banerjee and S. Risbud

Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411

038.

Raj Biotech Pvt. Ltd., Pune 411038

Group Companies of Specialty Enzymes and Biochemicals Co., Chino, California

91710 and Advanced Biochemicals Ltd. Thane 400601.

5) Renal fibrosis: Role of impaired protein degradation and potential

therapeutic strategies

Heidland A.1, Sebekova K.2, Paczek L.3, Teschner M.1, Daemmrich J.4, Gaciong

Z.3

1 Medical Faculty, University of Wuerzburg, 2 Institute of Preventive and

Clinical Medicine, Bratislava (Slovakia), 3 The Transplantation Institute

Warsaw (Poland), 4 Institute of Pathology, University of Wuerzburg (Germany)

Kidney International 1997, Vol. 52, Suppl. 62, pp. S 32- S 35

6) Enzymolysis of glomerular immune deposits in vivo with

dextranase/protease ameliorates proteinuria, hematuria, and mesangial

proliferation in murine

experimental IgA nephropathy

Gesualdo L., Ricanati S., Hassan M.O., Emancipator S.N., Lamm M.E.

Institute of Pathology and the *Department of Pathology, Veterans

Administration Hospital, Case Western Reserve University, Cleveland, Ohio 44106

J. Clin. Invest. 1990: Vol. 86, September 1990, pp. 715-722