Oxygen, Ozone, & Hydrogen Peroxide

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Oxygen, Ozone, & Hydrogen Peroxide

 

By Majid Ali, M.D.<majidalimd

_http://educate-yourself.org/cancer/ozonebymajidli17jul03.shtml_

(http://educate-yourself.org/cancer/ozonebymajidli17jul03.shtml)

July 17, 2003

 

(Abridgement from The Journal of Integrative Medicine article: Oxidative

Regression To Primordial Cellular Ecology (ORPEC))

The author's clinical experience has led him to conclude that oxygenative

antioxidant therapies such as nasal oxygen and intravenous infusions of

ozone-oxygen gas mixture and hydrogen peroxide are among the most beneficial

therapies for reversing the ORPEC state.

Since oxygen, ozone and hydrogen peroxide act as oxidants in a laboratory

setting, therapies employing those agents are generally deemed oxidative

therapies.191-193 Until recently, the author accepted that view uncritically.

However, it is clear from studies presented in this article that this is a

gross

error. In reality, such therapies in the context of the ORPEC state are

powerful oxygenative and antioxidant therapies. The reason for that widespread

misconception is the failure to clearly understand the complex biologic

consequences of adding oxygen, ozone, and hydrogen peroxide to severely

impaired

enzymatic and cellular ecosystems in patients with accelerated oxidative

injury.

A Burst of Thunderstorm, A Burst of Oxidants

 

An analogy of a burst of thunderstorm may be used to explain the possible

mechanism action of ozone. The still air in a city on a hot, humid summer

afternoon is thick with stagnant smog. The traffic on city streets is snarled.

Tree leaves are dry and limp. Many persons are distressed by air pollution.

Suddenly, dark clouds loom large and bring a heavy thunderstorm. Strong winds

push out the polluted air. Tree leaves are bombarded by heavy rains. The

healthy

and robust leaves of trees withstand the storm well, while older and

weakened leaves are severely damaged. Many withering leaves on tree brances are

blown away. After the thunderstorm subsides, the air is clean and crisp. The

trees looked washed, their leaves fresh and shiny. Bursts of intravenously

injected ozone and hydrogen peroxide affect the blood elements the same way.

The

membranes of healthy erythrocytes withstand the oxidative stress of ozone and

hydrogen peroxide well, recovering their normal morphology after initial

membrane deformities. The senescent cells, by contrast, shrink and undergo

lysis.

Below, some theoretical, clinical and experimental considerations are

presented that shed light on the apparent paradox of agents that are oxidizing

in

their essential roles, and yet provide the basis for oxygenative antioxidant

therapies.

Intermittent Nasal Oxygen

 

The oxygenative role of nasal oxygen is self-evident. Oxygen is also a

powerful oxidizer, as discussed earlier in the section devoted to spontaneity

of

oxidation in nature. The ORPEC hypothesis provides a clear scientific basis

for oxygen's ability to also serve the opposing antioxidant role. As discussed

earlier, anoxia increases oxidative stress directly by facilitating the

generation of toxic reactive species as well as indirectly by causing acidosis.

In this author's clinical experience, the use of intermittent nasal

administration of oxygen (2.5 to 3.5 L/min given for periods of one hour two or

three

times a day) benefits most patients in the ORPEC state. It is also the

opinion of the author that oxygen therapy is very underutilized in the care of

patients in the ORPEC state, such as those with fibromyalgia, chronic fatigue

state, severe autoimmune disorders, and spreading malignant tumors. Oxygen is

readily and inexpensively available to all patients. Also available are

inexpensive portable rental units that may be used in travel as well.

When used intermittently and in moderate doses as described here, this

therapy has been found to be completely free of adverse effects. The author

also

has limited experience with oxygen therapy in patients with severe pulmonary

emphysema and pulmonary interstitial fibrosis. Evidently, the use of oxygen in

such patients must be monitored closely so that oxygen therapy does not

cause further deterioration in the function of central sensors for oxygen and

carbon dioxide.

Intravenous Ozone Therapy

 

Ozone is triatomic oxygen with a high electrovoltaic potential. Ozone gas

infused intravenously at the Institute consists of a gaseous mixture with

oxygen containing a very low concentration of ozone. It is prepared by passing

pure oxygen through a high voltage field. The concentration of ozone generated

depends on the rate of flow of oxygen as well as on the conditions of voltage

and spacing of electrodes. The gaseous mixture used in our clinical practice

is titrated to contain from 0.3 to 2.5% (30 to 50 ug O3/ml O2). Thus,

intravenously administered " ozone " in reality represents 97 to 99.7% of pure

oxygen.

Practitioners who have never administered ozone gas mixture intravenously

often express concern about the possibility of air embolism caused by gas

infusion. Such concern is totally unwarranted. Pure oxygen and ozone diffuse

immediately into the blood and do not persist as gases. The author has tested

for

that on numerous occasions by injecting 2 ml of the ozone mixture into a

large vein, then immediately drawing the blood back. Except on uncommon

occasions, the blood drawn back from the vein is pink (ozone turns dark venous

blood

into pink blood) and free of any gas bubbles. One can safely presume that the

process of dissolution of the gas mixture would be complete by the time it

reaches the large veins in the thorax.

Another concern expressed by those unfamiliar with the clinical uses of

ozone mixture is the toxicity of ozone as discussed by environmentalists. It

must

be recognized that those individuals are perturbed by the products of

reaction of ozone with other ecopollutants such as oxides of nitrogen. Ozone is

a

highly reactive molecule. Indeed, ozone owes its many antiviral,

antibacterial, and antifungal properties to this aspect of this specific

aspect.

Microscopic Evidence for the Antioxidant Role of Intravenous Ozone Therapy

In the concentration used our in clinical practice, ozone causes temporary

and reversible erythrocyte membrane damage as evidenced by clumping and red

cell membrane deformity. The evidence for the oxidative nature of such

erythrocyte membrane deformities has been previously demonstrated by the

reversibility of such changes with antioxidants such as ascorbic acid,

tocopherol, and

taurine.56,57

How may the observed overall invivo antioxidant effects of ozone, a powerful

invitro oxidant, be explained? Ozone has well established effects of

improving tissue perfusion and cellular oxygenation.67 Just as the duality of

oxygen

allows it to be a molecular Dr. Jekyll and Mr. Hyde, reactive oxidant

species also play dual roles. Not only do they inflict oxidative damage to

enzymes,

induce mutations, and damage cell membranes, they also serve many useful

functions such as modulation of cellular redox dynamics, activation of gene

transcription, signal transduction, and apoptosis.93-95 It seems that ozone

evokes an upregulatory response from cell membrane-associated antioxidant

enzyme

systems just as all oxidants do from all biologic antioxidant systems. Though,

direct quantitative data for those effects are not yet forthcoming. One may

also, with good reason, speculate that ozone elicits similar responses from

other matrix- and cell organelle-related antioxidant systems. There is yet an

other important mechanism by which ozone protects patients with chronic

illnesses from accelerated oxidative stress. Viruses, bacteria, fungi, PLFs and

parasite inflict cellular injury by causing oxidative stress. Ozone also is a

well established antiviral, antibacterial, and antifungal agent.58-63. Ozone

through its powerful antimicrobial effects reduces the overall oxidative

stress on persons with chronic viral, bacterial, fungal and PLF overgrowth

syndromes. Thus, the ORPEC hypothesis carries strong explanatory power for the

empirically observed biologic antioxidant effects of ozone.

Intravenous Hydrogen Peroxide Therapy for the ORPEC State

 

The biologic antioxidant effects of hydrogen peroxide, a potent oxidizer

like ozone, are mediated by all the mechanisms cited for ozone in the preceding

section. The clinical benefits of hydrogen peroxide infusions observed at the

Institute in patients with fibromyalgia and chronic fatigue syndrome are the

subject of a separate report.72

Reference from the complete article in The Journal of Integrative Medicine

1998;2:4-55

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