warfarin and Chinese herbs

[Guest guest]

I searched wanfangdata for some info on warfarin and Chinese herbs.

 

---In one article, Chinese authors investigated the effect of Chinese herbs

TOGETHER on Deep Vein Thrombosus of the legs. Group A received herbs +

warfarin ( keeping plasma thrombinogen at 1.5) and group B received only

herbs.

Both groups had a marked effect, but the effect in group A was significantly

better: total cure for all 36 patients in this group, as measured with

Doppler effects, venography and rheologic examinations.\

 

Herbal formula was:

dang gui 15

chuan xiong 12

tao ren 12

hong hua 12

wu shao she 20

chai hu 12

niu xi 15

mu gua 20

 

with signifcant blood stasis:

plus ji xue teng 30

dan pi 15

tu yuan (di bie chong) 15

 

with pronounced damp evil:

plus fang ji 12

ze xie 12

yi mu cao 15

 

with accompanying yin vacuity:

plus sheng di 20

xuan shen 15

mai men dong 15

hua fen 20

 

 

So results were actually better with warfarin added. No contra-indications

are being mentioned.

Reference: Zhong guo zhong xi yi jie he wai ke za zhi Oct 2002 (year 8, ed.

5)

Title: Treatment of Deep Vein Thrombus of legs by combination of herbs with

effects of activating blood circulation and dispersing stasis and Warfarin

sodium

Authors: Song Hongfa, Dong Miaowei, Wang Qingxuan et al

 

 

---I found another reference to Chinese herbs and Warfarin in the treatment

of Atrial Fibrillation. This article appeared in Shanxi Zhong Yi 2005, year

26, ed. 7 and was authored by Shen Ninghong, Chen Yan and Zhu Bo.

In this article both groups were taking Warfarin, and one group also

received Yi Qi Hui Xue Fang, a formula with the following ingredients:

dang shen 20

mai men dong 20

huang qi 30

ting li zi 30

ge gen 30

dan shen 30

zhi fu zi 10

wu wei zi 10

ze xie 10

zhu ling 10

 

In the herbs plus warfarin group, INR (International normalized ratio) was

significantly better than in the warfarin group. There was no signifant

difference for aPTT (Activated Partial Thromboplastin Time) for both groups.

However, interestingly Warfarin dosage had been lowered in the herbal group.

 

 

 

---And according to another research article, Chinese herbs beat Warfarin in

the treatment of Renal Nephrotic Syndrome. Herbs were NOT taken together

with Warfarin in this study. FYI, the herbs used were Jian Pi Yi Shen Di Tan

Hua Yu Fang:

sheng huang qi 60

bai zhu 15

nu zhen zi 30

sha yuan zi 30

tu si zi 30

dan shen 30

dang shen 20

pu gong ying 10

fu ling 15

chuan xiong 15

di long 15

jiang can 15

 

with water swelling:

plus ze xie, zhu ling

 

with bloody urine:

1plus bai mao gen, xiao ji

 

with diabetes:

plus sheng di, xuan shen, hua fen

 

with proteinuria:

plus shi wei, he ye and higher dosage of huang qi

 

with lung infection:

plus yu xing cao, huang qin

 

susceptibility to common colds:

plus bai shao, fang feng

 

four limbs not warm:

plus fu zi, gan jiang

 

Reference for this article is: Shanxi Zhong Yi 2003, year 24, ed. 4. Author:

Wei Xiaomeng.

 

 

 

So two articles suggest that many Chinese herbs can be used together with

Warfarin, increasing therapeutic effectiveness and lowering warfarin dosage,

and one article showed that in the treatment of Renal Nephrotic Syndrome

Chinese herbs were better that warfarin alone.

 

Tom.