Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 On 11 Feb 2005 at 4:18, Rodrigo Gutierrez wrote: > Nicholas <solomon wrote: > Hello All- > I am currently studying Chinese Herbology. I am new to this, so please feel free to help me. > Cortisol is created in response to an exterior stress. What herb or herbal combination can someone use to deplete the amount of cortisol one has? I havent found anything yet. I would love some feedback and help. Rodrigo wrote: > Magnolia Bark Rodrigo, are you sure? Houpo-Cx Magniolia officinalis and Xinyi-Fl Magnoliae have marked antiinflammatory action and may increase steroidogenesis rather than decrease it. Magnolol stimulates steroidogenesis in rat adrenal cells. Dept of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China. smwang 1. This study investigated the effect of magnolol, a compound purified from Magnolia officinalis, on glucocorticoid production by primary adrenal cell culture. 2. Magnolol increased corticosterone secretion in a dose-dependent manner, this effect being maximal at 40 microM. A similar effect was seen in a minced adrenal gland system. 3. In magnolol-treated cells, the number and total area of cytoplasmic lipid droplets were reduced, suggesting a high utilization rate of cholesterol esters stored in lipid droplets. In control cells, the capsule of the lipid droplet was clearly delineated by immunostaining with antibody A2, whereas capsular staining was discontinuous or undetectable following magnolol treatment. The percentage of decapsulated cells increased significantly from 20% in the control group to 80% in the magnolol-treated group. 4. Magnolol- induced steroidogenesis was not mediated either via the traditional ACTH-cyclic AMP-protein kinase A pathway or by protein kinase C, since the intracellular cyclic AMP level did not change and inhibition of protein kinase A or C did not block the action of magnolol. Furthermore, calcium/calmodulin-dependent protein kinase II was not involved in magnolol-induced steroidogenesis. 5. The stimulatory effect of magnolol on steroidogenesis apparently requires new protein synthesis, since cycloheximide inhibited magnolol-induced corticosterone production by 50%. 6. Although other studies have shown that high concentrations of magnolol inhibit acyl-CoA: cholesterol acyltransferase and 11 beta- hydroxysteroid dehydrogenase in a cell-free system, our data show that, in adrenal cell cultures, low concentrations of magnolol have a stimulatory effect on steroidogenesis, and the glucocorticoid produced may explain the effective control of asthma by Magnolia officinalis. PMID: 11082125 [PubMed - indexed for MEDLINE] Kobayashi S, Kobayashi H, Matsuno H, Kimura I, Kimura M. Immunopharmacology. 1998 May;39(2):139-47. Inhibitory effects of anti-rheumatic drugs containing magnosalin, a compound from 'Shin-i' (Flos magnoliae), on the proliferation of synovial cells in rheumatoid arthritis models. Department of Chemical Pharmacology, Toyama Medical and Pharmaceutical University, Japan. This study was undertaken to examine the effects of magnosalin, a compound isolated from 'Shin-i' (Flos magnoliae) on proliferation of synovial cells isolated from MRL/1pr and collagen-induced arthritis (CIA) mice, and rheumatoid arthritis (RA) patients. Magnosalin (2.39-23.9 microM) inhibited 5% fetal bovine serum (FBS)-stimulated [3H]-thymidine incorporation into the synovial cells in the MRL/1pr mice. The effect of magnosalin was greater than that of hydrocortisone, bucillamine and magnoshinin (another compound from 'Shin-i'), but weaker than that of corticosterone. The effects of magnosalin for FBS-induced thymidine incorporation into the cells of the CIA mice and the RA patients were significantly greater than those in the corresponding control mice and osteoarthritis patients. Interleukin (IL)-1alpha increased the incorporation of thymidine into the synovial cells in the C57BL/6J mice to a greater degree than did basic fibroblast growth factor (bFGF) or platelet-derived growth factor BB-homodimer (PDGF-BB). The inhibitory effect of magnosalin on the submaximal action of IL-1alpha was significantly greater than that of bFGF, PDGF-BB or FBS. These results offer evidence that magnosalin suppresses the proliferation of synovial cells in RA models by inhibiting IL-1alpha-stimulated action. PMID: 9716260 [PubMed - indexed for MEDLINE] Wang JP, Hsu MF, Raung SL, Chen CC, Kuo JS, Teng CM. Anti- inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. Dept of Medical Research, Taichung Veterans General Hospital, Taiwan, Republic of China. Magnolol, isolated from Magnolia officinalis, inhibited mouse hind-paw edema induced by carrageenan, compound 48/80, polymyxin B and reversed passive Arthus reaction. Acetic acid- induced writhing response was depressed by magnolol, indomethacin and ibuprofen. The lethality of endotoxin challenge was reduced by pretreatment with magnolol, indomethacin and BW755C, a dual cyclo- oxygenase/lipoxygenase inhibitor. The recovered myeloperoxidase activity in edematous paw was significantly decreased in mice pretreated with magnolol and BW755C. Suppression of edema was demonstrated not only in normal mice but also in adrenalectomized animals. Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin. Unlike dexamethasone, magnolol did not increase liver glycogen level. The results suggest that the anti- inflammatory effect of magnolol was neither mediated by glucocorticoid activity nor through releasing steroid hormones from adrenal gland. The action of magnolol is proposed to be dependent on reducing the level of eicosanoid mediators. PMID: 1336574 [PubMed - indexed for MEDLINE] Best regards, Tel: (H): +353- or (M): +353- WWW: " Man who says it can't be done should not interrupt man doing it " - Chinese Proverb ---------- The following section of this message contains a file attachment prepared for transmission using the Internet MIME message format. If you are using Pegasus Mail, or any other MIME-compliant system, you should be able to save it or view it from within your mailer. If you cannot, please ask your system administrator for assistance. ---- File information ----------- File: WPM$5479_1.PNG 11 Feb 2005, 14:35 Size: 2962 bytes. 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Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 A adrenal exhaustion protocol with needles also works. Any experiences? Holmes Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 Adrenal exhaustion protocol with needles. What is it, Dr Holms? Peter Pavolotsky --- " Dr. Holmes Keikobad " <dkaikobad wrote: A adrenal exhaustion protocol with needles also works. Any experiences? Holmes To translate this message, copy and paste it into this web link page, http://babel.altavista.com/ and adjust accordingly. Messages are the property of the author. Any duplication outside the group requires prior permission from the author. If you are a TCM academic and wish to discuss TCM with other academics, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 Peter Pavolotsky wrote: > > Adrenal exhaustion protocol with needles. > > What is it, Dr Holms? > > Peter Pavolotsky > It is a novel approach which assesses the normalcy of adrenal function by checking out somatic points. If certain points or body sectors are tender, indurated, grainy, turgid, hard, soft, hollowed, full, heated, cold; the adrenals, atop the K's, are Deficient, which in WM parlance may mean lab tests show discrepancy. At which point, one checks out the adrenal reflex triggers against 'reducing' points which release the tension or impedimenta, so to say. If done well, one can reverse an adrenal deficiency to a significant extent in one sitting, which in WM parlance would mean an optimization of adrenal function, but without recourse to medications or hormones. A great deal of this thought is based on Matsumoto's work, built upon by my own in terms of reflexes and releases. Regards Dr. Holmes www.acu-free.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 Thank You, Dr. Holms Previously you mentioned adrenal reflex triggers in more details. I will try to experiment with my patients. Thank You again. Peter --- " Dr. Holmes Keikobad " <dkaikobad wrote: Peter Pavolotsky wrote: > > Adrenal exhaustion protocol with needles. > > What is it, Dr Holms? > > Peter Pavolotsky > It is a novel approach which assesses the normalcy of adrenal function by checking out somatic points. If certain points or body sectors are tender, indurated, grainy, turgid, hard, soft, hollowed, full, heated, cold; the adrenals, atop the K's, are Deficient, which in WM parlance may mean lab tests show discrepancy. At which point, one checks out the adrenal reflex triggers against 'reducing' points which release the tension or impedimenta, so to say. If done well, one can reverse an adrenal deficiency to a significant extent in one sitting, which in WM parlance would mean an optimization of adrenal function, but without recourse to medications or hormones. A great deal of this thought is based on Matsumoto's work, built upon by my own in terms of reflexes and releases. Regards Dr. Holmes www.acu-free.com To translate this message, copy and paste it into this web link page, http://babel.altavista.com/ and adjust accordingly. Messages are the property of the author. Any duplication outside the group requires prior permission from the author. If you are a TCM academic and wish to discuss TCM with other academics, Quote Link to comment Share on other sites More sharing options...
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