Guest guest Posted February 3, 2005 Report Share Posted February 3, 2005 Hi Everyone, Below are two references to the affect of curcumin on cancer cells. Now does anyone know in which type of cancer cells curcumin causes apoptosis, i.e. cell death? Best wishes, Peer-Reviewed Professional Journals · Jiang, M. C., et al. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutrition and Cancer. 26(1):111-120, 1996. Laypersons’ Publications · Safe and effective cancer prevention. Using natural therapies for the prevention of breast and other forms of cancer. Life Extension. 5(6):10-14, 1999. Test tube studies have demonstrated the ability of curcumin to induce apoptosis in human cancer cells. It can either inhibit apoptosis or promote it, depending on the type of cell. The apoptosis induced by curcumin differs to that of anti-cancer drugs used in chemotherapy. In-Tele-Health © 2002 (from Hyperhealth CD-ROM) -- Version: 7.0.300 / Virus Database: 265.8.2 - Release 28/01/2005 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2005 Report Share Posted February 3, 2005 Hi Sharon & All, SCHOLAR: curcumin apoptosis cancer cells http://tinyurl.com/4cowd GOOGLE: curcumin apoptosis cancer cells http://tinyurl.com/5cj7a > Hi Everyone, Below are two references to the affect of curcumin on > cancer cells. Now does anyone know in which type of cancer cells > curcumin causes apoptosis, i.e. cell death? Best wishes, Sharon > Bridgeman Peer-Reviewed Professional Journals · Jiang, M. C., et al. > Curcumin induces apoptosis in immortalized NIH 3T3 and malignant > cancer cell lines. Nutrition and Cancer. 26(1):111-120, 1996. > Laypersons’ Publications · Safe and effective cancer prevention. Using > natural therapies for the prevention of breast and other forms of > cancer. Life Extension. 5(6):10-14, 1999. Test tube studies have > demonstrated the ability of curcumin to induce apoptosis in human > cancer cells. It can either inhibit apoptosis or promote it, depending > on the type of cell. The apoptosis induced by curcumin differs to that > of anti-cancer drugs used in chemotherapy. In-Tele-Health © 2002 (from > Hyperhealth CD-ROM) Please feedback your analysis. Best regards, Tel: (H): +353- or (M): +353- WWW: " Man who says it can't be done should not interrupt man doing it " - Chinese Proverb ---------- Version: 7.0.300 / Virus Database: 265.8.4 - Release 01/02/2005 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2005 Report Share Posted February 3, 2005 Hi Phil, As always thanks for your quick response. I have had a fast look through, mainly looking at the research papers to see their proposed question and their conclusion, as truth to tell I am not medically literate to evaluate the technical jargon. So my assessment is based on researchers answering their question. My aim is to provide information to a client so that she can work with her doctor and possibly avoid surgery or at least do something in conjunction with such an approach. Her doctor thought she had at least 12 mths to try alternatives that position has now changed. So apart from raising my general knowledge, I am not likely to write much more of an analysis than what follows, until I have motivation to go further into such literature review. Legally I can't treat cancer as an acupuncturist and herbs are not my area of expertise. What I can say I have found is this: * There are a number of papers finding curcumin affective on killing cancer cells. * Astragalus can be useful in cancer treatment, immune support, and is anti viral, including against herpes simplex. * Cervical cancer is made up: a.. Squamous cell carcinomas make up about 85%-90% of all cervical cancers a.. Another 10%-15% are adenocarcinomas * There are some excellent pages explaining cervical dysplasia and the development phases to cancer of the cervix. * The goggle general search takes you to pages selling herbal formulas with curcumin with some reference to its effect on cancer. * Some articles require payment so I didn't get past their abstracts. I recall seeing on Australian 60 minutes the treatment/prevention of aids in sex workers with fresh lemon juice as a douche, and wonder if in general an acid environment would simply put it out of reach of virus's in general... another opportunity for research... but won't do much financially except perhaps for citrus growers. I conclude what is required are doctors prepared to work through the research in conjunction with OM doctors/therapist who can fine tune herbal formulae and or acupuncture treatments. Previously I reviewed some work that stated that there is usually an emotional stressor several years prior to the formation of cancer, so some emotional counselling is also probably in order. I now need to read if curcumin is effective against these types of carcinomas found in the cervix. Then the patient has to know via their doctor what their mix is and the doctor has to have an interest beyond chemo, radiation and surgery as therapy. As far as acupuncture goes, I had been treating her on and off for hip and other aches and pains previously. I have now found that the Chong vessel is extremely effective in pain management in the pelvis area for dysmenorrhea and also for post prolapse surgery of the bladder. Will this change in the pain change the cancerous nature of the tissue? Another great question that would be worth assessing. I suppose that would take having Px's in treatment with OM being assessed in conjunction with WM. I don't think this is a case for double blind clinical trials... I think treating Px one on one has to be what is assessed. And even then, the individual techniques of the practitioner and their interplay with their Px still can't really be duplicated religiously. The there is the problem of time and the fear of the cancer spreading from the cervix to the bladder, uterus LI, and liver... So I try to get a little more edjumacated and share that with Px's, however I know from previous Px that most will be scared enough by WM doctors to go for attack by chemical and radiation and the cut therapy of the knife. Best wishes, Sharon [] Thursday, 3 February 2005 11:22 AM Chinese Medicine Re: Curcumin and cancer cells Hi Sharon & All, SCHOLAR: curcumin apoptosis cancer cells http://tinyurl.com/4cowd GOOGLE: curcumin apoptosis cancer cells http://tinyurl.com/5cj7a Please feedback your analysis. Best regards, -- Version: 7.0.300 / Virus Database: 265.8.2 - Release 28/01/2005 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 4, 2005 Report Share Posted February 4, 2005 Hi Shar, & All, Medline has 20 hits for the profile: (apoptosis OR cancer) AND (curcum* OR zedoar*) http://tinyurl.com/4ggvz Unfortunately, ONE relates to cervical cancer (CC): Int J Cancer. 2005 Mar 1;113(6):951-60. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Prusty BK, Das BC. Division of Molecular Oncology, Institute of Cytology & Preventive Oncology (Indian Council of Medical Research), Maulana Azad Medical College Campus, New Delhi, India. The transcription factor AP-1 plays a central role in the transcriptional regulation of specific types of high-risk human papillomaviruses (HPVs) such as HPV16 and HPV18, which are etiologically associated with the development of cancer of the uterine cervix in women. In our study, we investigated the AP-1 binding activity and the expression pattern of different members of the AP-1 transcription factor family (c-Jun, JunB, JunD, c-Fos, FosB, Fra-1 and Fra-2) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors, including normal control tissues, using specific antibodies raised against each of the AP-1 members. Results indicate that though AP-1 showed high binding activity and the majority of its members were highly expressed in tumor tissues, there is a distinct pattern of gradual increase of c-fos and a concomitant decrease of fra-1 expression that perfectly match the progression of cervical lesions. While c-fos is highly expressed in invasive cervical tumor, the expression of fra-1 becomes almost nil or absent, but the reverse is true in both controls and early precancerous lesions. These findings corroborate the results obtained in the cervical cancer cell line, HeLa. Interestingly, despite very low or absent AP-1 binding in normal as well as in premalignant lesions, AP-1 transcription and its binding activity was found to be very high in malignant tissues showing a preferential heterodimerization of c-fos with JunB instead of its canonical dimerization partner c-jun. Both in vivo and in vitro studies demonstrate that the overexpression of c-fos and downregulation of fra- 1 expression as well as a change in the dimerization pattern of the AP-1 complex seem to play a crucial role during progression to malignancy. In a previous study, we demonstrated that a synthetic antioxidant, pyrrolidine dithiocarbamate (PDTC) can selectively downregulate HPV expression in human keratinocytes and cervical cancer cell lines. Since a redox regulatory pathway is involved in the expression of HPV that can be modulated by an antioxidant-induced reconstitution of the AP-1 transcription complex, we have used curcumin (diferuloylmethane), an active component of the perennial herb turmeric, which is a potent antioxidant and is well-known for its antiinflammatory and anticarcinogenic activity, to modulate the transcription of AP-1 and HPV. We demonstrate for the first time that curcumin can selectively downregulate HPV18 transcription as well as the AP-1 binding activity in HeLa cells. Most interestingly, curcumin can reverse the expression dynamics of c-fos and fra-1 in this tumorigenic cell line, mimicking the expression pattern observed in normal controls or precancerous lesions. Observation of curcumin-mediated complete downregulation of AP-1 binding activity and reversal of c-fos/fra-1 transcription to a normal state in tumorigenic HeLa cells represents a novel mechanism that can control transcription of pathogenic HPVs during keratinocyte differentiation and progression of cervical cancer. Our study thus provides a basis for developing a novel therapeutic approach to control pathogenic HPV infection by using potent antioxidative agents, such as curcumin. © 2004 Wiley-Liss, Inc. PMID: 15514944 [PubMed - in process] A Medline search for the profile: ( " cervical-cancer " OR " cancer-of-the- cervix " ) AND (herb OR herbs OR herba OR herbal) gave 13 hits. See: http://tinyurl.com/5qhra Best regards, Phil Sharon wrote: > > > Hi Phil, I have had a fast look through, mainly looking at the research > papers to see their proposed question and their conclusion, as truth to > tell I am not medically literate to evaluate the technical jargon. So > my assessment is based on researchers answering their question. My aim > is to provide information to a client so that she can work with her > doctor and possibly avoid surgery or at least do something in > conjunction with such an approach. Her doctor thought she had at least > 12 mths to try alternatives that position has now changed. So apart > from raising my general knowledge, I am not likely to write much more > of an analysis than what follows, until I have motivation to go further > into such literature review. Legally I can't treat cancer as an > acupuncturist and herbs are not my area of expertise. What I can say I > have found is this: * There are a number of papers finding curcumin > affective on killing cancer cells. * Astragalus can be useful in > cancer treatment, immune support, and is anti viral, including against > herpes simplex. * Cervical cancer is made up: a.. Squamous cell > carcinomas make up about 85%-90% of all cervical cancers a.. Another > 10%-15% are adenocarcinomas * There are some excellent pages > explaining cervical dysplasia and the development phases to cancer of > the cervix. * The goggle general search takes you to pages selling > herbal formulas with curcumin with some reference to its effect on > cancer. * Some articles require payment so I didn't get past their > abstracts. I recall seeing on Australian 60 minutes the > treatment/prevention of aids in sex workers with fresh lemon juice as a > douche, and wonder if in general an acid environment would simply put > it out of reach of virus's in general... another opportunity for > research... but won't do much financially except perhaps for citrus > growers. I conclude what is required are doctors prepared to work > through the research in conjunction with OM doctors/therapist who can > fine tune herbal formulae and or acupuncture treatments. Previously I > reviewed some work that stated that there is usually an emotional > stressor several years prior to the formation of cancer, so some > emotional counselling is also probably in order. I now need to read if > curcumin is effective against these types of carcinomas found in the > cervix. Then the patient has to know via their doctor what their mix > is and the doctor has to have an interest beyond chemo, radiation and > surgery as therapy. As far as acupuncture goes, I had been treating her > on and off for hip and other aches and pains previously. I have now > found that the Chong vessel is extremely effective in pain management > in the pelvis area for dysmenorrhea and also for post prolapse surgery > of the bladder. Will this change in the pain change the cancerous > nature of the tissue? Another great question that would be worth > assessing. I suppose that would take having Px's in treatment with OM > being assessed in conjunction with WM. I don't think this is a case > for double blind clinical trials... I think treating Px one on one has > to be what is assessed. And even then, the individual techniques of > the practitioner and their interplay with their Px still can't really > be duplicated religiously. The there is the problem of time and the > fear of the cancer spreading from the cervix to the bladder, uterus LI, > and liver... So I try to get a little more edjumacated and share that > with Px's, however I know from previous Px that most will be scared > enough by WM doctors to go for attack by chemical and radiation and the > cut therapy of the knife. Best wishes, Sharon I agree that it is wise not to dissuade Px from receiving WM Tx. However, CC has been linked to HPV (human papilloma virus), which is a sexually-transmitted disease. Also, women Dxed with CC, who have had multiple sexual partners, esp during pregnancy, have a very poor prognosis to treatment, even if that is a combination of radical surgery (including removal of local lymph nodes) + chemo + radiotherapy. Therefore, I would advise any female friend Dxed with CC to take homeopathic THUJA after finishing WM treatment. Thuja is said to be very effective to treat warts and other Sxs caused by HPV. I would also advise acupuncture on Repro Pts + Immune Pts (to help local + general immunity) + high-dose selenium + Vit E (antioxidants). As an alternative to (or combined with) curcumin, one might consider a course of Artemisinin - a potent active compound from Qinghao with anticancer activity. See: Pharmacol Res. 2003 Sep;48(3):231-6. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Chen HH, Zhou HJ, Fang X. Dept of Pharmacology and Toxicology, College of Pharmacology, Zhejiang University, Zhejiang 310031, Hangzhou, PR China. chenh552 Artemisinin derivatives artesunate (ART) and dihydroartemisinin are remarkable anti-malarial drugs with low toxicity to humans. In the present investigation, we find they also inhibited tumor cell growth and suppressed angiogenesis in vitro. The anti-cancer activity was demonstrated by inhibition (IC(50)) of four human cancer cell lines: cervical cancer Hela, uterus chorion cancer JAR, embryo transversal cancer RD and ovarian cancer HO-8910 cell lines growth by the MTT assay. IC(50) values ranged from 15.4 to 49.7 microM or from 8.5 to 32.9 microM after treatment with ART or dihydroartemisinin for 48 h, indicating that dihydroartemisinin was more effective than ART in inhibiting cancer cell lines. The anti-angiogenic activities were tested on in vitro models of angiogenesis, namely, proliferation, migration and tube formation of human umbilical vein endothelial (HUVE) cells. We investigated the inhibitory effects of ART and dihydroartemisinin on HUVE cells proliferation by cell counting, migration into the scratch wounded area in HUVE cell monolayers and microvessel tube-like formation on collagen gel. The results showed ART and dihydroartemisinin significantly inhibited angiogenisis in a dose- dependent form in range of 12.5-50 microM and 2.5-50 microM, respectively. They indicated that dihydroartemisinin was more effective than ART in inhibiting angiogenesis either. These results and the known low toxicity are clues that ART and dihydroartemisinin may be promising novel candidates for cancer chemotherapy. PMID: 12860439 [PubMed - indexed for MEDLINE] Best regards, Tel: (H): +353- or (M): +353- WWW: " Man who says it can't be done should not interrupt man doing it " - Chinese Proverb ---------- The following section of this message contains a file attachment prepared for transmission using the Internet MIME message format. If you are using Pegasus Mail, or any other MIME-compliant system, you should be able to save it or view it from within your mailer. If you cannot, please ask your system administrator for assistance. ---- File information ----------- File: WPM$6271_1.PNG 4 Feb 2005, 0:28 Size: 2962 bytes. Type: Unknown ---------- The following section of this message contains a file attachment prepared for transmission using the Internet MIME message format. If you are using Pegasus Mail, or any other MIME-compliant system, you should be able to save it or view it from within your mailer. 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Guest guest Posted February 4, 2005 Report Share Posted February 4, 2005 Thanks Phil, Perhaps she can get her doctor to monitor the response to curcumin which does work on cervical cancer. Best wishes, -- Version: 7.0.300 / Virus Database: 265.8.4 - Release 1/02/2005 Quote Link to comment Share on other sites More sharing options...
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