Diabetic Nephropathy and Hachimi-jio-gan

[Guest guest]

In a message dated 12/18/2004 11:53:00 AM Eastern Standard Time,

alonmarcus writes:

 

Hachimi-jio-gan

>>>What is it?

 

 

 

Grabbed from Internet:

 

" It’s an ancient Chinese “recipe†made with a precise blend of eight

different herbs. It includes Asiatic Dogwood, Chinese Yam, Mountain Peony,

Polyporous mushroom, Rehmannia, Alisma, Schisandra, and Honey fried Astragalus. "

 

 

It was unheard of by myself also. I was reading some info on a product

for eye sight and they mentioned it as part of the ingredient list. I then

made the best guess at the correct spelling and goggled it. I came up with the

study that I posted.

 

Hope that helps,

 

Chris

 

 

 

[Guest guest]

Thought this was interesting.

 

Enjoy,

 

Chris

 

 

 

 

 

 

Journal Home

Editorial Board

Guidelines

Issues

 

 

 

 

 

Advertising

Subscriptions

Free Alert

Online Sample

 

 

 

 

 

 

 

 

 

Vol. 97, No. 2, 2004

 

Free Abstract Article (Fulltext) Article (PDF 283 KB)

 

 

 

Original Paper

A Study on the Effects to Diabetic Nephropathy of Hachimi-jio-gan in Rats

Takako Yokozawaa, Noriko Yamabea, Eun Ju Choa, Takako Nakagawaa, Shigeru

Oowadab

 

aInstitute of Natural Medicine, Toyama Medical and Pharmaceutical University,

Toyama and

bFirst Department of Internal Medicine, St. Marianna University School of M

edicine, Kanagawa, Japan

 

Address of Corresponding Author

Nephron Experimental Nephrology 2004;97:e38-e48 (DOI: 10.1159/000078405)

 

 

 

Key Words

Hachimi-jio-gan

Diabetic nephropathy

Advanced glycation end-products

Sorbitol

Lipid peroxidation

Glomerular sclerosis

Tubulointerstitial lesion

 

 

 

Abstract

To investigate the effects of Hachimi-jio-gan on diabetic nephropathy, we

employed an animal model, rats subjected to sub-total nephrectomy followed by

streptozotocin injection, and administered Hachimi-jio-gan orally at a dose of

50, 100 or 200 mg/kg body weight/day for 15 weeks. The administration of

Hachimi-jio-gan reduced dose-dependently the elevated blood glucose and urinary

protein excretion levels in rats with diabetic nephropathy over the experimental

period, whereas it increased creatinine clearance significantly, suggesting that

Hachimi-jio-gan would prevent or delay the progression of diabetic

nephropathy. In addition, the serum glycosylated protein and urea nitrogen

levels were

markedly elevated in rats with diabetic nephropathy compared with normal rats,

and were significantly reduced by the administration of Hachimi-jio-gan,

whereas Hachimi-jio-gan reversed the decrease in the serum albumin level. The

serum

triglyceride and total cholesterol concentrations were reduced by

Hachimi-jio-gan, implying that Hachimi-jio-gan would improve the metabolic

disorder of

lipids caused by diabetic nephropathy. Moreover, Hachimi-jio-gan inhibited lipid

peroxidation in the serum and kidney, which suggests that Hachimi-jio-gan

would ameliorate oxidative stress associated with diabetic nephropathy.

Furthermore, the disorders of the glucose-dependent metabolic pathway due to

this

pathological condition were also normalized by the administration of

Hachimi-jio-gan through decreases in advanced glycation end-product formation

and sorbitol

levels in the kidney. Hachimi-jio-gan protected against the development of

renal lesions, glomerular sclerosis, tubulointerstitial lesions, mesangial

matrix

expansion and arteriolar sclerosis, estimated by histopathological evaluation

and scoring. This study suggests that Hachimi-jio-gan may be a novel

therapeutic approach to improving diabetic nephropathy.

2004 S. Karger AG, Basel

 

 

 

Author Contacts

Dr. Takako Yokozawa

Institute of Natural Medicine

Toyama Medical and Pharmaceutical University

2630 Sugitani, Toyama 930-0194 (Japan)

Tel. +81 76 4347631, Fax +81 76 4344656, E-Mail yokozawa

 

 

 

Article Information

Received: December 2, 2003

Accepted: January 8, 2004

Number of Print Pages : 11

Number of Figures : 3, Number of Tables : 4, Number of References : 49

 

 

 

[Guest guest]

Rehmannia Eight Formula

 

 

Bai Wei Di Huang Wan

 

 

Hachimi-jio-gan

 

 

 

Musiclear [Musiclear]

Sat 12/18/2004 11:32 AM

 

Cc:

Re: Diabetic Nephropathy and Hachimi-jio-gan

In a message dated 12/18/2004 11:53:00 AM Eastern Standard Time,

alonmarcus writes:

 

Hachimi-jio-gan

>>>What is it?

 

 

 

Grabbed from Internet:

 

" It’s an ancient Chinese “recipe” made with a precise blend of eight

different herbs. It includes Asiatic Dogwood, Chinese Yam, Mountain Peony,

Polyporous mushroom, Rehmannia, Alisma, Schisandra, and Honey fried Astragalus. "

 

 

It was unheard of by myself also. I was reading some info on a product

for eye sight and they mentioned it as part of the ingredient list. I then

made the best guess at the correct spelling and goggled it. I came up with the

study that I posted.

 

Hope that helps,

 

Chris

 

 

 

[Guest guest]

H07

 

Eight-Ingredient Formula with Rehmannia Extract Granules

 

(Hachimi-jio-gan; Bai Wei Di Huang Wan)

 

Description:

 

The daily dose of 7.5g (3 unit packets) contains 4.40g of

Eight-Ingredient Formula with Rehmannia extract powder:

 

Rehmannia Root (Shu di huang)……….5.0g

Cornus Fruit (Shan zhu yu)…………….3.0g

Dioscorea Rhizome (Shan yao)……….. 3.0g

Alisma Rhizome (Ze xie)………………3.0g

Moutan Bark (Mu dan pi)……………....3.0g

Cinnamon Bark (Gui pi)………………..1.0g

Hoelen (Fu ling)………………………...3.0g

 

Processed Lateral Root of Aconite (Fu zi)…1.0g

 

Standardization Specification:

 

This product is standardized to contain 0.75-2.27 mg/day of Aconitine,

8.1-15.2 mg/day of Paeoniflorin, and 0.26-0.62 mg/day of Cinnamic acid.

 

Therapeutic Recommendation (“Shoâ€):

 

Available in the Professional Catalog. Request it from Honso USA with a

valid healthcare professional license.

 

TCM Formulation Strategy:

 

Shu di huang is the chief herb, which can nourish yin and tonify the

kidneys. Shan zhu yu and shan yao，the deputy herbs，tonify the liver

and spleen and benefit the vital energy. They can also assist the kidney

yang together with acrid, hot fu zi and rou gui. The chief and assistant

herbs together have the effect of tonifying the kidneys and benefiting

the essence as well as nourishing the kidneys and warming yang. This is

the method of saving yang from yin. Zexie and fu ling have the effect of

eliminating the dampness evil. Mu dan pi clears away minister’s fire.

They have the effect of tonifying the body, although evil is eliminated,

and the greasy nature of yin-nourishing herbs is avoided. All these

herbs coordinated together are warm but not dry; nourishing but not

greasy. They can warm the yang and activate vital energy, nourish

deficiency of yin and produce yang, so that kidney yang is strengthened,

activity of vital energy is restored, and all syndromes are recovered.

 

 

 

 

Musiclear wrote:

 

> In a message dated 12/18/2004 11:53:00 AM Eastern Standard Time,

> alonmarcus writes:

>

> Hachimi-jio-gan

> >>>What is it?

>

>

>

> Grabbed from Internet:

>

> " It’s an ancient Chinese “recipe†made with a precise blend of eight

> different herbs. It includes Asiatic Dogwood, Chinese Yam, Mountain

> Peony,

> Polyporous mushroom, Rehmannia, Alisma, Schisandra, and Honey fried

> Astragalus. "

>

>

> It was unheard of by myself also. I was reading some info on a

> product

> for eye sight and they mentioned it as part of the ingredient list. I

> then

> made the best guess at the correct spelling and goggled it. I came up

> with the

> study that I posted.

>

> Hope that helps,

>

> Chris

>

>

>

[Guest guest]

Hachimi-jio-gan

>>>What is it?

 

 

 

[Guest guest]

Hachimi-jio-gan is the japanesse name for Ba Wei Di

Huang Wan formula.

I use it quite a bit in my practice.

 

Alejandro Fernandez Lic. Ac. MSOM

 

--- Alon Marcus <alonmarcus wrote:

 

> Hachimi-jio-gan

> >>>What is it?

>

>

> [Non-text portions of this message have been

> removed]

>

>

 

 

 

 

 

 

Send a seasonal email greeting and help others. Do good.

http://celebrity.mail.